Giant condyloma acuminatum is a large, slow-growing, exophytic, cauliflower-like tumor of the external genitalia. It is a histologically benign lesion, largely associated with human papillomavirus infection but with a high recurrence rate. The main differential diagnosis includes verrucous carcinoma. Differentiation between these 2 types of tumors is important with respect to treatment and prognosis. We present a case report of a 26-year-old woman with giant condyloma acuminata of the vulva and discuss the histological features and treatment modalities of this condition.