Skip Navigation LinksHome > January 2010 - Volume 14 - Issue 1 > Colposcopic Characteristics of High-Risk Human Papillomaviru...
Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e3181b0fb8e
Original Articles

Colposcopic Characteristics of High-Risk Human Papillomavirus-Related Cervical Lesions

Louwers, Jacqueline A. MD1,2; Kocken, Mariëlle MD2,3; van der Bijl, Joyce C. MSc1,2; Berkhof, Johannes PhD4; Snijders, Peter J.F. PhD2; Meijer, Chris J.L.M. MD, PhD2; Verheijen, René H.M. MD, PhD5

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Objective. Because high-risk human papillomavirus (hrHPV) is the necessary factor in the development of high-grade cervical lesions, knowing the colposcopic differences between hrHPV-positive and hrHPV-negative lesions could be of value. We have evaluated whether there are colposcopic differences between lesions testing hrHPV-positive or hrHPV-negative.

Materials and Methods. This study was conducted as a retrospective case-control study. We designed a scoring system for colposcopic criteria that might be of relevance to distinguish hrHPV-positive from hrHPV-negative lesions. Colposcopic images were analyzed from patients at the VU University Medical Center Amsterdam, the Netherlands, in whom a GP5+/6+ polymerase chain reaction hrHPV test had been performed within a month of the colposcopic examination (n = 507).

Results. Visibility of the transformation zone (corrected for age), a (very) coarse and irregular punctation pattern, and a large lesion (>25% of the visible cervix) were more often associated with a positive hrHPV test status (p =.001, odds ratio [OR] = 2.29, 95% CI = 1.41-3.73; p =.036, OR 2.37, 95% CI = 1.08-5.19; and p =.044, OR = 1.78, 95% CI = 1.08-2.94, respectively). After correction for histologic diagnosis, the difference between hrHPV-positive and hrHPV-negative lesions for visibility of the transformation zone and lesion size remained statistically significant (OR = 2.44, 95% CI = 1.35-4.41 and OR = 1.92, 95% CI = 1.04-3.54, respectively).

Conclusions. This study indicates that visibility of the transformation zone, (very) coarse punctation pattern, and larger lesion size were the main colposcopic features associated with a hrHPV-positive test status.

©2010The American Society for Colposcopy and Cervical Pathology


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