Skip Navigation LinksHome > January 2010 - Volume 14 - Issue 1 > Colposcopic Characteristics of High-Risk Human Papillomaviru...
Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e3181b0fb8e
Original Articles

Colposcopic Characteristics of High-Risk Human Papillomavirus-Related Cervical Lesions

Louwers, Jacqueline A. MD1,2; Kocken, Mariëlle MD2,3; van der Bijl, Joyce C. MSc1,2; Berkhof, Johannes PhD4; Snijders, Peter J.F. PhD2; Meijer, Chris J.L.M. MD, PhD2; Verheijen, René H.M. MD, PhD5

Spanish Translation
Collapse Box

Abstract

Objective. Because high-risk human papillomavirus (hrHPV) is the necessary factor in the development of high-grade cervical lesions, knowing the colposcopic differences between hrHPV-positive and hrHPV-negative lesions could be of value. We have evaluated whether there are colposcopic differences between lesions testing hrHPV-positive or hrHPV-negative.

Materials and Methods. This study was conducted as a retrospective case-control study. We designed a scoring system for colposcopic criteria that might be of relevance to distinguish hrHPV-positive from hrHPV-negative lesions. Colposcopic images were analyzed from patients at the VU University Medical Center Amsterdam, the Netherlands, in whom a GP5+/6+ polymerase chain reaction hrHPV test had been performed within a month of the colposcopic examination (n = 507).

Results. Visibility of the transformation zone (corrected for age), a (very) coarse and irregular punctation pattern, and a large lesion (>25% of the visible cervix) were more often associated with a positive hrHPV test status (p =.001, odds ratio [OR] = 2.29, 95% CI = 1.41-3.73; p =.036, OR 2.37, 95% CI = 1.08-5.19; and p =.044, OR = 1.78, 95% CI = 1.08-2.94, respectively). After correction for histologic diagnosis, the difference between hrHPV-positive and hrHPV-negative lesions for visibility of the transformation zone and lesion size remained statistically significant (OR = 2.44, 95% CI = 1.35-4.41 and OR = 1.92, 95% CI = 1.04-3.54, respectively).

Conclusions. This study indicates that visibility of the transformation zone, (very) coarse punctation pattern, and larger lesion size were the main colposcopic features associated with a hrHPV-positive test status.

©2010The American Society for Colposcopy and Cervical Pathology

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.