Skip Navigation LinksHome > October 2009 - Volume 13 - Issue 4 > Vulvar Intraepithelial Neoplasia 3 in Women Less Than 35 Yea...
Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e318196bd23
Original Articles

Vulvar Intraepithelial Neoplasia 3 in Women Less Than 35 Years

Kesterson, Joshua P. MD; Lele, Shashikant MD

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Objective. To examine the outcome of women diagnosed with vulvar intraepithelial neoplasia (VIN) 3 at less than 35 years.

Materials and Methods. All cases of VIN 3 treated in women less than 35 years treated at Roswell Park Cancer Institute between January 1973 and January 2008 were reviewed. Medical records were reviewed for year of diagnosis, treatment modality, recurrence and/or progression, associated medical conditions, history of genital condyloma, smoking status, history of cervical pathology, and treatment.

Results. Thirty-one women were identified. The mean age at diagnosis was 29 years. Smoking status was available in 28 patients, of which 82% (23/28) were current or former smokers. Eighty-one percent (25/31) of the women had cervical disease. Fifty-two percent (16/31) had a history of genital condyloma. Ten of the 31 women (32%) were diagnosed with persistence or recurrence of VIN 3. Three women (9.7%) progressed to invasive carcinoma.

Conclusions. Women diagnosed with VIN 3 at less than 35 years are at risk for persistence and/or recurrence of their disease as well as progression to carcinoma, warranting frequent and prolonged follow-up with liberal utilization of directed biopsies of suspicious lesions.

©2009The American Society for Colposcopy and Cervical Pathology


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