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Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e31819f3a2a
Original Articles

Prevalence and Relapse Impact of Lymphovascular Invasion at Early-Stage Cervical Cancer: Prevalence of Lymphovascular Invasion in Cervical Cancer

Magno, Valentino MD1; Rivoire, Waldemar A. PhD1; Mônego, Heleusa MD1; Appel, Marcia MD1; dos Reis, Ricardo MD, PhD1; Hammes, Luciano S. MD, PhD1; Edelweiss, Maria Isabel MD, PhD2; Capp, Edison MD, PhD1,3

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Abstract

Objective. This study aimed to determine the prevalence of lymphovascular invasion (LVSI) in the cervix and its survival impact on women with early-stage cervical cancer specimens who underwent radical hysterectomy.

Materials and Methods. Lymphovascular invasion was reviewed in 107 cases of cervical cancer stages IB1 and IIA and compared with the original pathological examination. In addition, the relapse impact was calculated appropriately for each patient and compared with the presence of LVSI.

Results. Lymphovascular invasion in the cervix was detected in 17.8% (9/107) of the cases (95% CI = 11.37-25.87) in the original pathological examination, and when the samples were reviewed specifically looking for this finding in this study, 74.8% (80/107) of the cases (95% CI = 65.9-82.31) were positive. Patients were followed for a mean of 4.87 ± 2.66 years, and tumor relapse was not different among patients with (27.5%; 22/80) and without (7.4%; 2/27) LVSI (p =.058), although a strong tendency was demonstrated.

Conclusions. The LVSI prevalence is underestimated in routine pathological examinations, and its rate increases considerably when carefully reviewed. The association between its presence and a worse prognosis needs further investigation.

©2009The American Society for Colposcopy and Cervical Pathology

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