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Prevalence and Relapse Impact of Lymphovascular Invasion at Early-Stage Cervical Cancer: Prevalence of Lymphovascular Invasion in Cervical Cancer

Magno, Valentino MD1; Rivoire, Waldemar A. PhD1; Mônego, Heleusa MD1; Appel, Marcia MD1; dos Reis, Ricardo MD, PhD1; Hammes, Luciano S. MD, PhD1; Edelweiss, Maria Isabel MD, PhD2; Capp, Edison MD, PhD1,3

Journal of Lower Genital Tract Disease: October 2009 - Volume 13 - Issue 4 - p 256-259
doi: 10.1097/LGT.0b013e31819f3a2a
Original Articles
Spanish Translation

Objective. This study aimed to determine the prevalence of lymphovascular invasion (LVSI) in the cervix and its survival impact on women with early-stage cervical cancer specimens who underwent radical hysterectomy.

Materials and Methods. Lymphovascular invasion was reviewed in 107 cases of cervical cancer stages IB1 and IIA and compared with the original pathological examination. In addition, the relapse impact was calculated appropriately for each patient and compared with the presence of LVSI.

Results. Lymphovascular invasion in the cervix was detected in 17.8% (9/107) of the cases (95% CI = 11.37-25.87) in the original pathological examination, and when the samples were reviewed specifically looking for this finding in this study, 74.8% (80/107) of the cases (95% CI = 65.9-82.31) were positive. Patients were followed for a mean of 4.87 ± 2.66 years, and tumor relapse was not different among patients with (27.5%; 22/80) and without (7.4%; 2/27) LVSI (p =.058), although a strong tendency was demonstrated.

Conclusions. The LVSI prevalence is underestimated in routine pathological examinations, and its rate increases considerably when carefully reviewed. The association between its presence and a worse prognosis needs further investigation.

The prevalence of lymphovascular invasion in early cervical cancers is underestimated and usually much higher than described, but its clinical impact is still unknown.

1Department of Obstetrics and Gynecology, Division of Genital Oncology, 2Department of Pathology, and 3Laboratory of Molecular Obstetrics and Gynecology, Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil

Reprint requests to: Valentino Magno, MD, Engenheiro Olavo Nunes 435/202, CEP 90440-170, Porto Alegre, Rio Grande do Sul, Brazil. E-mail: valentinoamagno@hotmail.com

©2009The American Society for Colposcopy and Cervical Pathology