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Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e31819b224e
Original Articles

Molluscum Contagiosum: Therapeutic Response to Trichloroacetic Acid in Pregnant Patients

Audisio, Teresita M. MD1; Pelliza Palmes, Maria Nuria MD1; Ringelheim, Claudia MD1; Rodríguez González, Oscar MD1; Crespo Roca, Francisco MD1; Ruperez, Casilda BSc2

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Abstract

Objective: This study aimed to evaluate the clinical response of pregnant patients affected by Molluscum contagiosum (MC) to treatment with a 90% solution of trichloroacetic acid (TCA). It also aimed to study the diagnostic frequency of MC in adult women coming for consultation to a Lower Genital Tract Office hospital-based outpatient clinic in the city of Cordoba (Argentina) and, second, to study the response of the MC to treatment with Imiquimod cream in some cases.

Materials and Methods: A retrospective case-series analysis of 30 patients presenting with MC. The data collected included the prevalence of MC in pregnant versus nonpregnant women, patient age, frequency age, lesion location, and associated pathologies.

Results: The prevalence levels of MC in pregnant and nonpregnant women were 1.2% and 0.8%, respectively. The greatest frequency was found in the 16- to 20-year age group. No patient was HIV+. Lesion location was 54.5% in the genitocrural fold, with the rest in the perianal region and in different areas of the external genitalia. The patients were treated during a minimum period of 1 week to a maximum period of 4 weeks. A 90% solution of TCA treatment showed full response after a single application, 17 (94%) of the 18 showed full response, averaging 1.06 weeks of treatment. Three nonpregnant patients were treated with a 5% solution of imiquimod, 66.6% showing full response by the fourth week of treatment.

Conclusions: We observed MC in the genital area of young pregnant patients relatively frequently (3%), associating its presence with diminished immune response. A 90% solution of TCA is highly effective with 1 application, the subsequent pain and burning sensation being immediately reduced by the application of aluminum hydroxide.

©2009The American Society for Colposcopy and Cervical Pathology

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