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"Pagetoid" Eccrine Carcinoma of the Vulva: Report of an Unusual Case With Review of the Literature

Grin, Andrea MD1; Colgan, Terrence MD2; Laframboise, Stephane MD3; Shaw, Patricia MD1; Ghazarian, Danny MB ChB1

Journal of Lower Genital Tract Disease: April 2008 - Volume 12 - Issue 2 - pp 134-139
doi: 10.1097/LGT.0b013e31815b2156
Case Reports

Sweat gland carcinoma of the vulva is rare and may be classified as being of eccrine, apocrine, or mixed origin. Most reported cases of vulvar sweat gland carcinomas associated with extramammary Paget disease describe a tumor of apocrine origin. We report a case of a vulvar sweat gland carcinoma of eccrine origin associated with Pagetoid extension. A review of the literature and the differential diagnosis are also presented. To our knowledge, this is the second case of vulvar sweat gland carcinoma of eccrine origin associated with extramammary Paget disease.

A rare vulvar sweat gland carcinoma of eccrine origin associated with extramammary Paget disease is presented with a review of the literature.

1Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Canada, 2Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Canada, 3Department of Gynecologic Oncology, University Health Network, Toronto, Canada

Reprint requests to: Danny Ghazarian, MB, ChB, FRCPC, PhD, Department of Laboratory Medicine and Pathobiology, University of Toronto, and University Health Network, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2M9. E-mail: Dr.Danny.Ghazarian@uhn.on.ca

©2008The American Society for Colposcopy and Cervical Pathology