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Complete Resolution of Paget Disease of the Vulva With Imiquimod Cream

Hatch, Kenneth D. MD; Davis, John R. MD

Journal of Lower Genital Tract Disease:
doi: 10.1097/LGT.0b013e31815a58a5
Original Articles
Spanish Translation

Extra mammary Paget disease (EMPD) is a neoplastic disease of apocrine gland bearing skin. Surgical excision is the standard of care for EMPD; however, it is accompanied by recurrence in more than 60% of the patients. Recently, imiquimod cream has been reported to induce complete responses in primary or recurrent EMPD. We report on 2 women with vulva EMPD who achieved biopsy-confirmed resolution of their disease after topical application of imiquimod 5% cream.

In Brief

Two patients with Paget disease of the vulva are successfully treated with imiquimod, and the literature is reviewed.

Author Information

University of Arizona, Tucson, AZ

Reprint requests to: Kenneth D. Hatch, MD, University of Arizona, PO Box 245078, Tucson, AZ 85724-5078. E-mail:

©2008The American Society for Colposcopy and Cervical Pathology