Objective. Primary solitary fibrous tumors (SFTs) of the female genital tract are exceedingly rare. We report a spindle cell tumor of the vagina with features consistent with a SFT in a 52-year-old woman.
Materials and Methods. The original tumor was studied with the appropriate panel of immunohistochemical stains. The first recurrence of the tumor was 10 months after its original incomplete excision, and a second recurrence occurred 29 months later. Both recurrences were analyzed using the same immunohistochemical panel.
Results. After considering several related differential diagnoses, the diagnosis of SFT was made based on the morphological and immunophenotypic features.
Conclusion. To the best of our knowledge, this is the third case of vaginal SFT in the English literature, with 2 recurrences after incomplete excision.