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Journal of Investigative Medicine:
doi: 10.1097/JIM.0000000000000094
Brief Report

Autoantibodies to C-Reactive Protein in Incomplete Lupus and Systemic Lupus Erythematosus

Jung, Ju-Yang MD; Koh, Bo-Ram MD; Kim, Hyoun-Ah MD; Jeon, Ja-Young PhD; Suh, Chang-Hee MD, PhD

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Abstract

Objective

Anti-C-reactive protein (CRP) antibodies have been described in patients with systemic lupus erythematosus (SLE). We investigated the potential of the anti-CRP antibody as a marker for disease activity in SLE patients and as a predictor of progression to SLE in patients with incomplete lupus.

Methods

Immunoglobulin G anti-CRP antibody levels were measured using an enzyme-linked immunosorbent assay.

Results

Patients with incomplete lupus exhibited clinical and immunologic characteristics different from those in SLE patients: no serositis and alopecia, more common oral ulcers and arthritis, lower disease activity index, lower positivity for antinuclear and anti–double-strand DNA antibodies, and higher complement levels. Anti-CRP antibody levels were higher in SLE patients (35.6 [35.1] AU) than in patients with incomplete lupus (23.1 [25.8] AU, P = 0.016) and normal controls (21.0 [14.3] AU, P < 0.001). Anti-CRP antibody was significantly higher in SLE patients with arthritis and correlated with disease activity markers, including antichromatin antibody. However, no difference in anti-CRP antibody levels was observed between patients with incomplete lupus that progressed to SLE and those whose did not.

Conclusion

These data suggest that anti-CRP antibodies can neither be used as biomarkers in SLE nor predict SLE progression in patients with incomplete lupus.

Copyright © 2014 by The American Federation for Medical Research

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