Skip Navigation LinksHome > February 2014 - Volume 62 - Issue 2 > Triglyceride Glucose Index and Common Carotid Wall Shear Str...
Journal of Investigative Medicine:
doi: 10.231/JIM.0000000000000043
Original Articles

Triglyceride Glucose Index and Common Carotid Wall Shear Stress

Tripolino, Cesare MD; Irace, Concetta MD; Scavelli, Faustina B. MD; de Franceschi, Maria S. MD; Esposito, Teresa MD; Carallo, Claudio MD; Gnasso, Agostino MD

Collapse Box

Abstract

Objectives

Alterations in wall shear stress contribute to both clinical and subclinical atherosclerosis. Several conditions such as hypertension, diabetes, and obesity can impair shear stress, but the role of insulin resistance has never been investigated. The present study was designed to investigate whether insulin resistance assessed by TyG Index associates with wall shear stress in the common carotid artery.

Methods

One hundred six individuals were enrolled. Blood pressure, lipids, glucose, and cigarette smoking were evaluated. TyG Index was calculated as log[fasting triglycerides × fasting glucose / 2]. Subjects underwent blood viscosity measurement and echo-Doppler evaluation of carotid arteries to calculate wall shear stress. The association between TyG Index and carotid wall shear stress was assessed by simple and multiple regression analyses.

Results

TyG Index was significantly and inversely associated with carotid wall shear stress both in simple (r = −0.44, P < 0.001) and multiple regression analyses accounting for age, sex, and major cardiovascular risk factors. The association was further confirmed after exclusion of subjects with diabetes, dyslipidemia, fasting blood glucose greater than 100 mg/dL, and triglycerides greater than 150 mg/dL.

Conclusions

The present findings suggest that increasing insulin resistance, as assessed by TyG Index, associates with atherosclerosis-prone shear stress reduction in the common carotid artery.

Copyright © 2014 by The American Federation for Medical Research

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.