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Journal of Investigative Medicine:
doi: 10.231/JIM.0000000000000013
Original Articles

The Relationship Between Platelet Collagen Receptor Glycoprotein VI and No-Reflow Phenomenon in Patients With Acute ST-Segment Elevation Myocardial Infarction

Kobat, Mehmet Ali MD*; Balin, Mehmet MD; Celik, Ahmet MD; Baydas, Adil MD*; Dagli, Mustafa Necati MD

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Abstract

Objectives

The purpose of this study was to determine whether admission soluble glycoprotein VI (sGP-VI) level is associated with no-reflow phenomenon (NRP) after primary percutaneous coronary intervention (P-PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI).

Methods

A total of 178 consecutive patients admitted to our hospital for a first STEMI and undergoing P-PCI within 12 hours of onset of symptoms were enrolled. The patients were divided into 2 groups (NRP group and reflow group). Admission sGP-VI plasma levels were measured by enzyme-linked immunosorbent assay.

Results

Of the 178 patients who underwent P-PCI, 41 patients (23%) developed NRP. The patients in the reflow group had higher levels of sGP-VI compared with the patients in the NRP group (38.5 ± 21.0 vs 21.9 ± 11.9 ng/mL, P < 0.001). The sensitivity and specificity values of the sGP-VI levels were 90% and 49%, respectively (cutoff value was ≤25). In the multivariate logistic regression analyses, sGP-VI levels of 25 ng/mL or lower, higher peak troponin T levels and body mass index value, amount of opaque of greater than 250 mL, and lesion length of greater than 13.5 mm were independent predictors of angiographic NRP.

Conclusions

Lower admission sGP-VI levels are associated with NRP in patients with STEMI undergoing P-PCI. This outcome may open new therapeutic facility in the setting of P-PCI.

Copyright © 2013 by The American Federation for Medical Research

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