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Journal of Investigative Medicine:
doi: 10.231/JIM.0000000000000019
Original Articles

Pediatric Nephrologists’ Beliefs Regarding Randomized Controlled Trials

Wightman, Aaron G. MD*†; Oron, Assaf P. PhD; Symons, Jordan M. MD*†; Flynn, Joseph T. MD, MS*†



In the article beginning on page 84 of the January 2014 issue, the supplemental digital content was not added.

The first line of column 1 on page 85 should have read:

The final survey (see Appendix, Supplemental Digital Content 1, contained 6 questions about provider beliefs regarding RCTs, 13 questions about factors influencing provider decisions to recommend enrollment in an RCT, and 3 demographic questions.

Journal of Investigative Medicine. 63(7):886, October 2015.

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Background: Pediatrics and pediatric nephrology lag behind adult medicine in producing randomized controlled trials (RCTs). Physician attitudes have been shown to play a significant role in RCT enrollment.

Methods: We surveyed members of the American Society of Pediatric Nephrology regarding beliefs about RCTs and factors influencing decisions to recommend RCT enrollment. Regression analyses were used to identify the effects of variables on an aggregate score summarizing attitudes toward RCTs.

Results: One hundred thirty replies were received. Sixty-six percent had enrolled patients in RCTs. Respondents in practice for more than 15 years were more likely to have recruited a patient to an RCT than those in practice for less than 5 years. Respondents were more willing to recommend RCT enrollment if the study was multicenter, patients were sicker or had a poorer prognosis, or if the parent or participant received a financial incentive versus the provider. In multiple regression analysis, history of enrolling patients in an RCT was the only significant predictor of higher aggregate RCT-friendly attitude.

Conclusions: Many pediatric nephrologists have never enrolled a patient in an RCT, particularly those in practice for less than 5 years. Respondents who have not enrolled patients in RCTs have a less RCT-friendly attitude. Provision of improved training and resources might increase participation of junior providers in RCTs.

Copyright © 2014 by the American Federation for Medical Research.


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