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Journal of Investigative Medicine:
doi: 10.231/JIM.0000000000000018
Original Articles

Clinical Implications in the Prevalence and Associated Cardiovascular Factors of Elevated Serum Alanine Aminotransferase Levels Among Elderly Agricultural and Fishing Population in Taipei, Taiwan: Experience at a Teaching Hospital

Chen, Yu-Fen MS*; Hu, Yi-Chun MS; Shen, Hsi-Che MD, PhD; Chang, Hui-Te BS§; Tung, Tao-Hsin PhD

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Aim: To discuss the prevalence and associated factors related to an elevated serum alanine aminotransferase (ALT) level among the elderly agricultural and fishing population.

Methods: A total of 6542 (3989 males and 2553 females) healthy adults voluntarily admitted to a teaching hospital for a physical checkup in 2010 in Taipei, Taiwan. Fasting blood samples were drawn via venipuncture, and clinical nurses interviewed the study participants using a structured questionnaire from.

Results: The overall prevalence of an elevated serum ALT level was 18.2% and revealed a statistically significant decrease with increasing age (P < 0.001). The men exhibited a higher prevalence than the women (19.7% vs 15.9%; P < 0.001). Male sex; younger age; and presence of obesity, hypertension, hyperuricemia, and hypoalbuminemia were significantly associated with an elevated serum ALT level. Sex-related differences were also revealed. For the men, type 2 diabetes (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.02–1.57), hypercholesterolemia (OR, 1.78; 95% CI, 1.22–2.83), hypertriglyceridemia (OR, 1.32; 95% CI, 1.04–1.73), and low high-density lipoprotein (OR, 1.26; 95% CI, 1.05–1.51) were significantly related to an elevated serum ALT level, but this was not so for the women. The disparity of ALT in age groups was revealed.

Conclusion: Several sex-related differences were indicated pertaining to the prevalence of an elevated serum ALT level among elderly specific occupational population.

Copyright © 2014 by the American Federation for Medical Research.


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