Skip Navigation LinksHome > January 2014 - Volume 62 - Issue 1 > A Cut-Point Value of Uncarboxylated to Carboxylated Index Is...
Journal of Investigative Medicine:
doi: 10.231/JIM.0000000000000015
Original Articles

A Cut-Point Value of Uncarboxylated to Carboxylated Index Is Associated With Glycemic Status Markers in Type 2 Diabetes

Villafán-Bernal, José Rafael MD, PhD*; Llamas-Covarrubias, Mara Anaís PhD; Muñoz-Valle, José Francisco PhD; Rivera-León, Edgar Alfonso PhD*; González-Hita, Mercedes Elvira PhD*; Bastidas-Ramírez, Blanca Estela PhD§; Gurrola-Díaz, Carmen Magdalena PhD§; Armendáriz-Borunda, Juan Socorro PhD; Sánchez-Enríquez, Sergio MD, PhD, MSc*

Collapse Box

Abstract

Background

The uncarboxylated osteocalcin (ucOC) has been described as a regulator of glucose metabolism in mice, and it is decreased in human type 2 diabetes mellitus (T2D). Although inversely correlated with serum glucose, insulin, and glycated hemoglobin, it is unclear if ucOC decrement is caused by diabetes or plays a role in the pathogenesis and/or progression of the disease. Whatever the case may be, diabetes affects osteoblast gene expression, and possibly the proportion of ucOC over carboxylated OC (cOC). The association of ucOC/cOC index with glycemic status markers in patients with T2D has not been described before.

Objective

The objective of this study was to assess the ucOC/cOC index and its relationship with glycemic status markers in patients with T2D.

Methods

The ucOC/cOC index was determined by the quotient of ucOC and cOC serum levels in 80 T2D patients and 160 healthy subjects. The relationship between the ucOC/cOC index and glycemic status markers was evaluated.

Results

The ucOC/cOC index was low and negatively correlated to fasting plasma glucose and homeostasis assessment-insulin resistance model in T2D patients. The odds ratio for T2D patients with an ucOC/cOC index below the cut-point obtained by receiver operating characteristic analysis was 12.64 (confidence interval, 5.75–27.77; P < 0.001).

Conclusions

A value of ucOC/cOC index less than 0.3 is associated with markers of poor metabolic control in patients with T2D.

Copyright © 2013 by The American Federation for Medical Research

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Readers Of this Article Also Read