Skip Navigation LinksHome > October 2013 - Volume 61 - Issue 7 > The Polymorphism of CLOCK Gene 3111T/C C>T Is Associated Wit...
Journal of Investigative Medicine:
doi: 10.231/JIM.0b013e31829f91c0
Original Articles

The Polymorphism of CLOCK Gene 3111T/C C>T Is Associated With Susceptibility of Alzheimer Disease in Chinese Population

Yang, Yun-Kang MD*; Peng, Xiao-Dong PhD; Li, Yong-Hong PhD‡§; Wang, Zheng-Rong MD*; Chang-quan, Huang MD; Hui, Wang MD; Liu, Qing-Xiu MD

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Objectives: In the present study, it was examined whether polymorphism of circadian locomotor output cycle kaput (CLOCK) gene 3111T/C was associated with susceptibility of Alzheimer disease (AD).

Methods: This study was conducted using a case-control method. Genotypes of apolipoprotein E (APOE e4) and CLOCK gene 3111T/C were determined by restriction fragment length polymorphism method and TaqMan assay method, respectively.

Results: In this study, we gathered 296 unrelated AD patients and 423 control subjects. Both in the whole sample and APOE e4 noncarriers, prevalence of C carriers in CLOCK gene 3111T/C in AD patients was significantly higher than that in control subjects (in the whole sample: χ2 = 37.615, P < 0.0001; in APOE e4 noncarriers: χ2 = 46.809, P < 0.0001). However, among APOE e4 carriers, prevalence of C carriers in CLOCK gene 3111T/C between patients and control subjects presents nonsignificant difference (χ2 = 0.812, P = 0.451).

Conclusions: Among APOE e4 noncarriers, C carriers in CLOCK gene 3111T/C were associated with a high susceptibility of AD, but among APOE e4 carriers, the functional polymorphism of CLOCK gene 3111T/C was not associated with the susceptibility of AD.

Copyright © 2013 by the American Federation for Medical Research.


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