Skip Navigation LinksHome > October 2012 - Volume 60 - Issue 7 > Serum Levels of Adipocyte Fatty Acid–Binding Protein Are Ind...
Journal of Investigative Medicine:
doi: 10.231/JIM.0b013e31826868f2
Original Articles

Serum Levels of Adipocyte Fatty Acid–Binding Protein Are Independently Associated With Left Ventricular Mass and Myocardial Performance Index in Obstructive Sleep Apnea Syndrome

Balci, Mustafa Mücahit MD*; Arslan, Uğur MD; Firat, Hikmet MD; Kocaoğlu, İbrahim MD*; Vural, Mustafa Gökhan MD§; Balci, Kevser Gülcihan MD§; Maden, Orhan MD*; Gürbüz, Oğuz Alp MD; Ardiç, Sadk MD‡ı; Yeter, Ekrem MD§

Collapse Box


Objective: To investigate the cross-sectional association between serum adipocyte fatty acid–binding protein (A-FABP) level and diagnosis or severity of obstructive sleep apnea syndrome (OSAS) and some echocardiographic indices related with cardiac dysfunction.

Methods: In this study, plasma A-FABP and high-sensitivity C-reactive protein concentrations were measured, and echocardiography was performed in subjects without any cardiac or pulmonary disease who were referred for evaluation of OSAS. According to the apnea-hypopnea index (AHI), subjects were classified into 3 groups: control group (AHI <5; n = 33), mild to moderate OSAS (30 > AHI ≥ 5; n = 30), and severe OSAS (AHI ≥ 30; n = 31).

Results: Levels of A-FABP were significantly different between the groups (P < 0.001). After post hoc analyses, all 3 groups were also significantly different from each other. The levels of A-FABP were significantly higher in the patients with severe OSAS (36.4 ± 13.0 ng/mL) than in the control subjects (9.3 ± 4.6 ng/mL; P < 0.0001) or in patients with mild-moderate OSAS (24.5 ± 10.5 ng/mL; P < 0.001). Patients with myocardial performance index (MPI) greater than 0.47 had higher serum A-FABP levels than those with MPI of less than 0.47 (31.8 ± 13.2 ng/mL vs 10.9 ± 6.3 ng/mL; P = 0.001). Multivariable regression analyses revealed that increased serum A-FABP concentrations were independently associated with increased left ventricular mass index (β = 0.195; P = 0.033) and increased MPI (β = 0.165; P = 0.015).

Conclusions: Increased A-FABP levels were found in the patients with OSAS, which were correlated significantly with left ventricular mass index and MPI. Further prospective studies are needed to clarify whether increased serum A-FABP level is a marker or a potential mechanism for left ventricular involvement in patients with OSAS.

Copyright © 2012 by the American Federation for Medical Research.


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.