Skip Navigation LinksHome > January 2012 - Volume 60 - Issue 1 > Glutathione S-Transferase Gene Polymorphisms in Neonatal Hyp...
Journal of Investigative Medicine:
doi: 10.231/JIM.0b013e318235479a
Original Articles

Glutathione S-Transferase Gene Polymorphisms in Neonatal Hyperbilirubinemia

Abdel Ghany, Eman Abdel Ghany MD*; Hussain, Nouran Fahmy MD*; Botros, Shahira Kamal Anis MD

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Abstract

Background: Glutathione S-transferases (GSTs) are a polymorphic superfamily of multifunctional enzymes known to play an important role in the detoxification of several substances. GSTM1 and GSTT1 are present in the liver in relatively high levels. Polymorphisms of the GSTM1 and GSTT1 genes may affect ligandin functions that are important in bilirubin transportation.

Objective: The aim of this study was to investigate the role of GSTM1 and GSTT1 gene polymorphisms as risk factors for neonatal jaundice.

Methods: This study was conducted on 72 neonates with pathologic hyperbilirubinemia (bilirubin >15 mg/dL) and 112 neonates with bilirubin level less than 15 mg/dL as a control group. GSTM1 and GSTT1 genotypes were assessed by multiplex polymerase chain reaction.

Results: GSTM1 null genotype was significantly higher in the patient compared with control groups (P = 0.005; odds ratio = 2.43; 95% confidence interval, 1.29–4.55) and was significantly associated with higher bilirubin levels compared with the wild genotype (P < 0.001). There was no statistically significant difference in the GSTT1 genotypes between the patient and the control groups. In the patient group, total bilirubin levels did not vary significantly among the null and wild GSTT1 genotypes (P = 0.108).

Conclusions: Neonates with the GSTM1 null genotype are at high risk to develop pathologic hyperbilirubinemia and may have higher bilirubin levels.

© 2012 American Federation for Medical Research

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