Skip Navigation LinksHome > December 2011 - Volume 59 - Issue 8 > Statin Therapy Reduces Growth of Abdominal Aortic Aneurysms
Journal of Investigative Medicine:
doi: 10.231/JIM.0b013e31823548e8
Original Articles

Statin Therapy Reduces Growth of Abdominal Aortic Aneurysms

Karrowni, Wassef MD*; Dughman, Saadeddine MD*; Hajj, Georges P. MD*; Miller, Francis J. Jr MD*†

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Abstract

Background: The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs).

Methods: We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance.

Results: Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, −1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0–4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors.

Conclusions: To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.

© 2011 American Federation for Medical Research

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