Skip Navigation LinksHome > October 2010 - Volume 58 - Issue 7 > Elevated Plasma Levels of Chemerin in Newly Diagnosed Type 2...
Journal of Investigative Medicine:
doi: 10.231/JIM.0b013e3181ec5db2
Original Articles

Elevated Plasma Levels of Chemerin in Newly Diagnosed Type 2 Diabetes Mellitus With Hypertension

Yang, Mengliu MD*†; Yang, Gangyi PhD†; Dong, Jing MD†; Liu, Ying MD†; Zong, Haihong MD‡; Liu, Hua PhD§; Boden, Guenther MD∥; Li, Ling MS*

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Abstract

Chemerin is a recently discovered metabolic regulator hormone. The pathophysiologic role of this hormone in humans remains unknown. In this study, we have compared plasma chemerin levels in patients with type 2 diabetes mellitus with or without hypertension and in control subjects. We also assessed the association of plasma chemerin with body composition and metabolic parameters in these subjects. Plasma chemerin levels were found to be markedly increased in patients with type 2 diabetes mellitus with hypertension as compared with patients with type 2 diabetes mellitus and normal controls (P < 0.01). Multiple regression analysis showed that waist circumference, diastolic blood pressure, 2-hour plasma insulin after glucose overload, and HbA1c were independently related factors influencing plasma chemerin levels. The present work indicates the potential link of chemerin with the pathogenesis of insulin resistance, obesity, and metabolic syndrome.

© 2010 American Federation for Medical Research

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