Skip Navigation LinksHome > February 2008 - Volume 56 - Issue 2 > The Role of PPARγ in Pulmonary Vascular Disease
Journal of Investigative Medicine:
doi: 10.231/JIM.0b013e318165e921
Original Articles

The Role of PPARγ in Pulmonary Vascular Disease

Hart, C. Michael MD

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Abstract

The peroxisome proliferator-activated receptor (PPAR) γ is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors. Thiazolidinediones, pharmacological ligands for PPARγ, are currently used in the management of type 2 diabetes. Peroxisome proliferator-activated receptor γ is expressed in the lung and pulmonary vasculature, and its expression is reduced in the vascular lesions of patients with pulmonary hypertension. Furthermore, thiazolidinedione PPARγ ligands reduced pulmonary hypertension and vascular remodeling in several experimental models of pulmonary hypertension. This report reviews current evidence that PPARγ may represent a novel therapeutic target in pulmonary hypertension and examines studies that have begun to elucidate mechanisms that underlie these potential therapeutic effects.

© 2008 American Federation for Medical Research

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