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Journal of Hypertension:
doi: 10.1097/01.hjh.0000378621.59601.09
Poster Session 07: Epidemiology of Hypertension and Metabolic Disorders 1

PROGRESSION TO HYPERTENSION IN THE CZECH POST-MONICA STUDY: 10-YEAR FOLLOW-UP: PP.7.297

Cifkova, R1; Skodova, Z1; Frohlich, J2; Lanska, V1; Bruthans, J1; Jozifova, M1; Adamkova, V1; Galovcova, M1; Wohlfahrt, P1; Krajcoviechova, A1

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1Inst. Clin. Exp. Medicine, Prague, Czech Republic

2Univ. British Columbia, Vancouver, Canada

Abstract

Objective: The Framingham study showed that high-normal BP (130–139/85–89 mmHg) is associated with an increased risk for cardiovascular disease and a higher rate of progression to hypertension. The aim of our study was to follow up a cohort of individuals with high-normal BP from a representative sample of the Czech population.

Design and Method: : In 1997/8, a cross-sectional survey of CV risk factors was performed in 3,209 individuals from 9 districts of the Czech Republic (a 1% population sample aged 25–64 years, mean age 45.76±10.6 years; response rate 64.4%), a subgroup of 2,502 was re-examined 10 years later. At baseline, hypertension was found in 781 individuals who were excluded from this analysis.

Results: : A stepwise increase in hypertension incidence occurred across the three normotensive BP categories; in males, 17.7% of participants with optimal BP, 35.9% with normal, and 63.0% with high-normal BP progressed to hypertension over 10 years; the respective figures in females were 15.5%, 41.6%, and 71.9%.

Conclusions: A high-normal BP at baseline was associated with a substantially increased risk of developing hypertension over a period of 10 years compared with optimal and normal BP. Age, obesity, and weight gain contributed independently to progression to hypertension.

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© 2010 Lippincott Williams & Wilkins, Inc.

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