1Inst. Clin. Exp. Medicine, Prague, Czech Republic
2Univ. British Columbia, Vancouver, Canada
Objective: The Framingham study showed that high-normal BP (130–139/85–89 mmHg) is associated with an increased risk for cardiovascular disease and a higher rate of progression to hypertension. The aim of our study was to follow up a cohort of individuals with high-normal BP from a representative sample of the Czech population.
Design and Method: : In 1997/8, a cross-sectional survey of CV risk factors was performed in 3,209 individuals from 9 districts of the Czech Republic (a 1% population sample aged 25–64 years, mean age 45.76±10.6 years; response rate 64.4%), a subgroup of 2,502 was re-examined 10 years later. At baseline, hypertension was found in 781 individuals who were excluded from this analysis.
Results: : A stepwise increase in hypertension incidence occurred across the three normotensive BP categories; in males, 17.7% of participants with optimal BP, 35.9% with normal, and 63.0% with high-normal BP progressed to hypertension over 10 years; the respective figures in females were 15.5%, 41.6%, and 71.9%.
Conclusions: A high-normal BP at baseline was associated with a substantially increased risk of developing hypertension over a period of 10 years compared with optimal and normal BP. Age, obesity, and weight gain contributed independently to progression to hypertension.