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Journal of Hypertension:
doi: 10.1097/01.hjh.0000379019.41062.4e
Poster Session 16: Clinical Trials 1

COMPARATIVE EFFECT OF LERCANIDIPINE AND AMLODIPINE IN THE TREATMENT OF MILD TO MODERATE HYPERTENSION: PP.16.93

Goda, A1; Tase, M1; Banushi, A1; Goda, T1; Pavli, E1; Dado, E1; Dibra, A1; Horjeti, B2

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1University Hospital Center Mother Theresa, Dept. of Cardiology, Tirana, Albania

2American Hospital, Tirana, Albania

Abstract

Calcium antagonists (CA) are very effective drugs recommended as first line therapy in hypertension.

The goal of this study is to compare the efficacy of two more used third generation dihydropyridine CA Lercanidipine (L) and Amlodipine (A).

Methods: Open-label, 28 weeks, cross-over study included 202 pts with mild to moderate hypertension. Following a washout phase of two weeks pts were randomized to treatment with 10 mg L (101 pts) or 5 mg A (101 pts) daily. In patients not responding adequately to treatment (DBP decrease < 10 mmHg or DBP > 90 mmHg) the dose was doubled after two weeks and treatment was mantained for other ten weeks. Following a second washout phase, treatments were crossed over for another 12 weeks period.

Results: In both L and A groups mean SBP and DBP were reduced during the treatment. In L group, mean SBP was reduced from bazal 159.6 ± 8.3, 4 weeks 137.0 ± 9.0 (p < 0.001), 12 weeks 135.4 ± 8.8 mmHg (p < 0.001) and mean DBP from bazal 96.5 ± 4.3, 4 weeks 84.9 ± 4.4 (p < 0.001), 12 weeks 83.7 ± 4.4 mmHg (p < 0.001). In A group, mean SBP was reduced from basal 159.8 ± 8.0, 4 weeks 139.2 ± 9.1 (p < 0.001),12 weeks 136.2 ± 8.9 mmHg (p < 0.001) and mean DBP from basal 96.7 ± 4.3, 4 weeks 85.9 ± 5.0 (p < 0.001), 12 weeks 84.9 ± 5.1 mmHg (p < 0.001). Change effect on BP was more pronounced in L-group than in A-group respectively for SBP 22.5 ± 7.7 vs 20.7 ± 6.7 mmHg after 4 weeks (p = 0.01) and 24.2 ± 7.5 vs 22.7 ± 7.7 mmHg after 12 weeks (p < 0.05), and for DBP 11.7 ± 3.9 vs 10.9 ± 4.5 mmHg after 4 weeks (p = 0.07) and 12.9 ± 4.1 vs 11.7 ± 4.9 mmHg after 12 weeks (p = 0.01). L-treatment had higher responder rate (2 weeks: 53% vs 34%, p < 0.001 and 12 weeks: 93.9% vs 87.4%, p = 0.03) and was more effective in the normalization of BP (<140/90 mmHg) (12 weeks: 68.3% vs 56.4%, p < 0.01) compared to A-treatment.

Conclusions: Both L and A were effective in terms of BP reduction but the effect of L resulted to be superior in our group of patients.

© 2010 Lippincott Williams & Wilkins, Inc.

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