Journal of Hypertension:
European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the Second International Consensus Conference on Home Blood Pressure Monitoring
Parati, Gianfrancoa; Stergiou, George Sb; Asmar, Rolandc; Bilo, Grzegorza; de Leeuw, Peterd; Imai, Yutakae; Kario, Kazuomif; Lurbe, Emparg; Manolis, Athanasiosh; Mengden, Thomasi; O'Brien, Eoinj; Ohkubo, Takayoshik; Padfield, Paull; Palatini, Paolom; Pickering, Thomasn; Redon, Josepo; Revera, Miriama; Ruilope, Luis Mp; Shennan, Andrewq; Staessen, Jan Ar; Tisler, Andrass; Waeber, Bernardt; Zanchetti, Albertou; Mancia, Giuseppev; on behalf of the ESH Working Group on Blood Pressure Monitoring
aDepartment of Clinical Medicine and Prevention, University of Milano-Bicocca; Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Milan and Department of Cardiology, S.Luca Hospital, Istituto Auxologico Italiano, Milan, Italy
bHypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece
cL'Institut CardioVasculaire, Paris, France
dDivision of General Internal Medicine, Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands
eDepartment of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
fDivision of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
gPediatric Department, Consorcio Hospital General, University of Valencia, Valencia, Spain
hFirst Department of Cardiology, Evagelismos General Hospital of Athens, Athens, Greece
iDivision of Hypertension and Vascular Medicine, Department of Internal Medicine, University Clinic Bonn, Bonn, Germany
jConway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
kDepartment of Planning for Drug Development, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan
lDepartment of Medical Sciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
mClinica Medica 4, University of Padova, Padua, Italy
nColumbia University Medical College, New York, New York, USA
oHypertension Clinic, Internal Medicine, Hospital Clinico, University of Valencia, Valencia, Spain
pHypertension Unit, 12 de Octubre Hospital, Madrid, Spain
qMaternal and Fetal Research Unit, Kings College London, Division of Reproduction and Endocrinology, St. Thomas Hospital, Westminster Bridge Road, London, UK
rLaboratory of Hypertension, Campus Gasthuisberg, Leuven, Belgium
s1st Department of Medicine, Semmelweis University, Budapest, Hungary
tDivision de Physiopathologie Clinique MP14, Lausanne, Switzerland
uCentro Interuniversitario di Fisiologia Clinica e Ipertensione and Istituto Auxologico Italiano, Milan, Italy
vClinica Medica, Department of Clinical Medicine and Prevention, University of Milano-Bicocca; Centro Interuniversitario di Fisiologia Clinica e Ipertensione, Milan and Istituto Auxologico Italiano, Milan, Italy
Received 30 April, 2008
Accepted 14 May, 2008
Correspondence to Gianfranco Parati, MD, Department of Cardiology, Ospedale San Luca, Istituto Auxologico Italiano, via Spagnoletto 3, 20149 Milan, Italy Tel: +39 02 619112980; fax: +39 02 619112956; e-mail: firstname.lastname@example.org
This document summarizes the available evidence and provides recommendations on the use of home blood pressure monitoring in clinical practice and in research. It updates the previous recommendations on the same topic issued in year 2000. The main topics addressed include the methodology of home blood pressure monitoring, its diagnostic and therapeutic thresholds, its clinical applications in hypertension, with specific reference to special populations, and its applications in research. The final section deals with the problems related to the implementation of these recommendations in clinical practice.
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Abbreviations AAMI: American Association for the Advancement of Medical Instrumentation; ABP: ambulatory blood pressure; ABPM: ambulatory blood pressure monitoring; BHS: British Hypertension Society; CHD: coronary heart disease; CKD: chronic kidney disease; DBP: diastolic blood pressure; ESH: European Society of Hypertension; ESRD: end stage renal disease; GFR: glomerular filtration rate; HBP: home blood pressure; HBPM: home blood pressure monitoring; HBPT: home blood pressure telemonitoring; MH: masked hypertension; OBP: office blood pressure; PE: pre-eclampsia; SBP: systolic blood pressure; WCH: white coat hypertension; WHO: World Health Organization.
The need to develop the current guidelines is related to the fact that home blood pressure monitoring (HBPM) is becoming increasingly important in the diagnosis and management of arterial hypertension. The rapid diffusion of this technique has been favoured by a number of factors, including technical progress and wider availability of HBPM devices, increasing awareness of the importance of regular BP monitoring, and recognition of the usefulness of HBPM by international hypertension management guidelines [1–3].
The importance of HBPM in cardiovascular prevention, related to a deeper involvement of patients in their long-term management and the wide diffusion of this approach in populations, is not always accompanied by adequate knowledge of how to make proper use of this technique, which emphasizes the need for more precise recommendations (Box 1).
Purpose and scope of these guidelines
The purpose of the present guidelines is to update the recommendations given in the first consensus document on HBPM, published in year 2000 . Like the previous document, this paper is also written to provide physicians and other healthcare providers with information on the use of HBPM in clinical practice on the basis of the available evidence and expert opinion. An Appendix to this article, which will be published online, is devoted to patients' information and training programmes. These guidelines are not aimed at dealing with the technological, economical and public health related aspects of HBPM use.
HBPM is an area in which data from randomized controlled trials of sufficient power are still limited. This does not allow a formal grading of recommendations based on the available evidence. Nonetheless, the Writing Committee made a great effort to provide objective recommendations, through extensive retrieval of published data, and by establishing task forces to prepare and discuss separate documents on specific topics.
The published data were retrieved by identifying relevant English language articles on the subject of HBPM in computerized databases (Medline and Embase; Cochrane) and personal literature. The search was performed on publications using the following keywords: home BP; self-BP measurement; BP monitoring; BP determination; with the subheadings: validity, reliability, methods, instrumentation, patient education, self-care, validation, clinical relevance, prognostic value and devices. Only non-invasive methods, clinical and cohort studies with normotensive subjects as well as treated and untreated hypertensive patients, were selected.
The material related to the use of HBPM was divided into a number of topics and assigned to different task forces. For each topic, several questions/issues were defined and addressed by the task force in a draft document. These draft documents were then reviewed by the Writing Committee and subsequently presented during the Consensus Conference. Each presentation was followed by an open discussion involving all the participants. The manuscripts were amended accordingly and finally reviewed by the Writing Committee, experts and by relevant organizations, leading to this final document.
Background: general issues related to blood pressure measurement in and out of office– validity of home blood pressuring monitoring in the evaluation of hypertensive patients
Office BP (OBP) measurement has been the cornerstone of hypertension diagnosis and management for over 100 years, with most evidence on the clinical importance of hypertension and benefits of treatment coming from studies using this technique . However, OBP measurement has important limitations. In particular, a single OBP reading often does not represent a patient's true BP status. This is because a random error characterizes a single measurement of a variable such as BP, which changes continuously over time. There may also be a systematic error related to the patient's alerting reaction to the measurement procedure and setting (i.e. white coat effect) and the inability of OBP to collect information on BP during usual daytime activities and during sleep.
Following the pioneering work by George Pickering and Maurice Sokolow in the 1960s, several techniques have been developed to perform BP measurements outside of the physician's office in order to overcome the limitations of the OBP. Two of them have become widely used in clinical practice: 24-h ambulatory BP monitoring (ABPM; addressed extensively by other documents ) and HBPM, with its specific features described in Box 2.
Important differences are frequently found between OBP and out-of-office BP measurements in the same individual, which may lead to disagreement between these methods in terms of hypertension diagnosis. Such disagreement may be characterized by the presence of elevated OBP values and normal out-of-office BP [i.e. white coat hypertension (WCH), also known as ‘isolated office hypertension’]  or, alternatively, of elevated out-of-office BP with normal OBP values (i.e. masked hypertension or ‘isolated ambulatory hypertension’) . These conditions will be discussed in more detail subsequently.
Cost and availability have a major influence on the choice of the method of BP measurement. OBP measurement is cheaper than ABPM and should ideally be performed during each visit to the physician's office. The use of ABPM in routine clinical practice is confined mainly to specific conditions, due to the cost of devices and the need to have qualified personnel for ABPM management. On the contrary, the cost of HBPM devices no longer limits their widespread use in clinical practice, at least in developed countries. Moreover, the specifications for HBPM devices for low-resource settings provided recently by an ad-hoc WHO–European Society of Hypertension (ESH) committee may help to introduce out-of-office BP monitoring in places where healthcare resources are scarce .
Home blood pressure monitoring and prognosis
The available evidence [10–23] supports the notion that the prognostic value of HBPM is equal to or higher than that of OBP, a method which, at present, remains the point of reference for prognostic stratification and clinical decision making in hypertension (Table 1).
Predictive value for mortality
HBP was more closely associated with the risk of cardiovascular mortality than OBP in two population studies [10,19,20], whereas in one study it was not a significant predictor of cardiovascular mortality in hypertensive patients . In a study on chronic kidney disease (CKD) patients, HBP tended to be more strongly associated with the risk of all-cause mortality . Another population study reported that systolic HBP had a higher predictive value for cardiovascular mortality than diastolic HBP .
Predictive value for morbidity
Compared with OBP, HBP was more closely associated with the risk of stroke in one population study (no data for other outcomes) [12–15,24], whereas in another population study, no prognostic superiority of HBP was found for the risk of cardiovascular events . In hypertensive patients, HBP was shown to predict cardiovascular events (but not mortality) better than OBP . In patients with CKD, HBP is a better predictor of progression to end stage renal disease (ESRD)  and of composite cardiovascular events  than OBP.
In some studies, the prognostic value of HBPM was documented without comparing it with OBP, providing evidence in favour of the ability of HBP to predict mortality , disability  and target organ damage [26–36] or its regression [31,37,38].
Little is known on the usefulness of home-measured heart rate (HR), a parameter that is usually provided by automated BP devices. Out-of-office HR is more reproducible than clinic HR, but in the studies that used HR obtained with 24-h ABPM this advantage did not seem to translate into a better risk prediction, compared with conventional resting HR [39–41]. In the only study available on the prognostic relevance of home-measured HR , a 5 beats/min increase in home HR corresponded to a 17% increase in the risk of mortality, but this result was not confronted with the predictive power of clinic HR.
In conclusion, the available evidence strongly supports HBPM as a valid tool for prognostic assessment. Areas that need further research include the prognostic significance of other parameters derived from HBPM, such as heart rate or pulse pressure, and the relation of HBPM with individual outcomes [e.g. coronary artery disease (CAD)]. More prospective studies in Western populations appear to be needed.
The recommendations that follow are based on previously published documents [1,2,4] as well as on more recent data. Unless stated differently, the current document will refer to the use of automated devices with an inflatable cuff for the upper arm (see the section Device selection and validation) (Box 3).
Measurement conditions and procedures
BP is a variable haemodynamic phenomenon influenced by many factors, not least being the circumstances of measurement itself. Thus, the considerable variability that may occur in BP from moment to moment depending on individual's activity, emotions, environmental stressors, pharmacological factors and other physiological variables [7,43,44] should always be considered when performing a BP measurement. If these influences are ignored or unrecognized, erroneous diagnosis and inappropriate management may result.
The effect of these factors can be minimized by performing measurements in conditions as carefully standardized as possible and by taking them into account when interpreting the results of HBPM. The conditions of HBPM should be similar to those recommended for OBP . The patient should be relaxed in the sitting position (most data on HBPM have been obtained with sitting measurements), with the back supported, the cuff at heart level, without crossing legs, in a quiet room at a comfortable temperature and at least 5 min of rest should precede the measurement. Patients should not talk before and during BP measurement. When it is not possible to achieve optimum conditions, this should be reported with the BP reading .
If the arm in which measurement is being made is unsupported, isometric exercise is being performed, increasing BP (up to 10%) and heart rate . It is essential, therefore, for the arm to be supported during BP measurement and this is best achieved in practice by having the arm supported on a table (for sitting position).
When the arm (i.e. the cuff) is positioned below or above heart level, BP will be overestimated or underestimated, respectively. The magnitude of this error can be as great as 10 mmHg in sitting and standing positions or 5 mmHg in the supine position. Inappropriate forearm position is even more important when wrist BP monitors are used, as it introduces a large error margin on top of the limited accuracy commonly seen in these devices . Because of this, some wrist devices have a built-in sensor, which indicates the correct position .
We recommend that BP measurement on both arms should only be done at the time of the first office measurement to exclude occlusive arterial disease [49,50]. In individuals with a consistent and significant between-arm difference (e.g. >10 mmHg systolic and/or >5 mmHg diastolic) on repeated measurements, the arm with the higher BP should be selected for future measurements . During HBPM, measurements should be performed sequentially always on the same arm.
Cuff and bladder
The size of a bladder is important to obtain accurate BP estimates. A bladder which is too small may lead to overestimation (undercuffing) and a bladder which is too large may lead to underestimation (overcuffing) of actual BP . The length of the inflatable bladder should cover 80–100% of the arm circumference and the width should be about half that of the length . No satisfactory solution to the problem of cuff size has been found so far. Different cuff sizes are recommended for patients with different arm circumferences as well as in children at different ages  (Box 4); and before the patients start using a BP device, it must be ensured that the bladder dimensions are adequate. For each measurement, the cuff should be wrapped round the upper arm with the centre of the bladder placed over the brachial artery.
The methodology of BP measurement in obese people is discussed in more detail in a dedicated section later on in this paper.
Accurate reporting of BP readings must be ensured, as it has been shown that HBPM reported by patients frequently differs from the actually measured values . Not only BP but also HR values measured at home should be reported. This is because, as already mentioned, home-measured HR not only provides information on cardiovascular risk  but may also help in a better interpretation of home BP values (may suggest the presence of factors that influence BP, e.g. physical or emotional stress, arrythmias, etc.).
For more discussion on data reporting, see the section Home blood pressure monitoring and telemedicine.
Few patients are unable to perform HBPM when automated oscillometric monitors are used. This technique may be unsuitable for patients with physical problems or mental disabilities, unless the measurements can be taken by another person (e.g. family member), which, however, may affect the HBP values .
HBPM is most suited to hypertensive patients who wish to contribute to their own management. At present, HBPM is frequently performed by patients on their own initiative using devices purchased without medical advice [55,56]. This leads to frequent problems, such as the use of inaccurate devices and errors in measurement methodology. The knowledge of patients about appropriate cuff size is also minimal. This situation may discourage primary care physicians from making a more widespread use of HBPM in everyday practice . Such an attitude could be improved if the doctors themselves become familiar with the strengths and limitations of HBPM, aware of the accuracy and reliability of the equipment being used by their patients, and informed on the state of the market for automated devices. Proper training of patients on methodology and interpretation of HBPM may reduce the likelihood of errors during measurement  and provide reliable assessment of HBP.
There is currently no standardized approach to educating patients about HBPM. Perhaps involvement of members of the healthcare team, such as nurses in primary care practices, specialized nurses or pharmacists , or a combination of different methods may be needed . Additional resources such as CD-ROMs, booklets (see suggested reading on the Journal of Hypertension Web site) or access to dedicated Web sites are useful for demonstrating HBPM to patients.
Device selection and validation
Monitors available for HBPM theoretically may include mercury-column sphygmomanometers, aneroid manometers and electronic semiautomatic devices (Box 5). Mercury-column sphygmomanometers are cumbersome, require the training of the patient in the auscultatory method and the mercury contributes to environmental pollution. Thus, not only are they not recommended, but they are no longer on the market in several countries [59,60]. Aneroid manometers also require skill by the patient and training by the physician, and they can become inaccurate with use . For these reasons, these devices are also not recommended for routine use. Recently, mercury-free manual devices based on the auscultatory method and on use of electronic transducers have been developed. Although they also require patient training, they may be useful for individuals in whom automated measurements are not feasible, e.g. because of arrhythmias or inaccuracy of oscillometric measurement.
All currently available automated and semiautomated HBPM devices use the oscillometric technique. They are popular with patients mainly because of simplicity of use. These devices are widely advertised and sold in pharmacies and even supermarkets, usually without instructions or education from a knowledgeable health professional. In consequence, a vast array of such devices is manufactured and marketed, many of which have not been independently evaluated for use in clinical practice (see www.dableducational.org). Three categories of these devices are available: devices that measure blood pressure on the upper arm, the wrist and the finger.
Devices that measure BP at the finger are not recommended, because peripheral vasoconstriction, alteration in BP in the more distal site of recording, and a particularly relevant effect of limb position on BP lead to important inaccuracies of measurement .
Automatic wrist monitors are popular among patients, because measurement is readily obtained without the need to remove clothing. These devices, however, are subject to the same limitations as the finger devices, including distal site and limb position. Measurement with wrist devices is heavily influenced by not only the level at which the wrist is held but also its flexion and hyperextension. Furthermore, wrist devices are inherently less accurate because of the difficulties in producing an accurate algorithm to estimate systolic blood pressure (SBP) and diastolic blood pressure (DBP), as there are two arteries contributing to the oscillometric signal. As a result, there continue to be strong reservations about the use of wrist devices for routine clinical practice. However, additional studies have been advocated to explore the role of wrist measuring devices in special populations, such as obese or elderly individuals, in whom HBPM using the upper arm is more difficult to perform .
Upper arm devices
Monitors that measure BP in the upper arm (brachial artery) have been shown to be the most reliable in clinical practice and research and therefore their use is recommended for HBPM. The majority of general recommendations on BP measurement apply to these devices, including the need for availability of appropriate cuff sizes. Validated electronic upper arm devices should thus be preferred for HBPM, particularly those offering the possibility to store, transmit or print measurements. The possible exceptions include patients in whom it is not possible to measure BP with these devices (patients with arrhythmias; in some patients, automated measurement is not possible, with no obvious reason).
SBP and DBP values provided by oscillometric devices are derived by means of device-specific algorithms that are not disclosed by manufacturers. Because of this heterogeneity and the marketing of a multitude of devices, patients should be certain that the device they purchase has been validated according to agreed-upon criteria. Based on the experience from studies using earlier validation protocols of the American Association for the Advancement of Medical Instrumentation (AAMI) and British Hypertension Society (BHS) , the Working Group on BP Monitoring of the ESH has developed a simplified and updated protocol, without sacrificing the integrity of earlier protocols. This ‘International Protocol’ was drafted so as to be applicable to the majority of BP measuring devices on the market and has already been used in numerous studies . Apart from ‘standard’ validation studies, the Writing Committee also recommends independent validation of devices for use in special populations (children, pregnant women, patients with hypertension associated with pregnancy, elderly people, obese individuals, etc.).
Besides validation for clinical accuracy, devices should also undergo technical quality certification based on additional characteristics that make their use safe, easy and clinically useful for disease management. Recently a Quality Certification Protocol for previously validated devices was proposed, which should provide objective information on both accuracy and overall quality of BP monitors .
The Writing Committee agreed on the need to define procedures for assuring the accuracy of validation studies themselves. A proposal for such procedures is currently being prepared by the Working Group on BP Monitoring of the ESH.
As only a minority of SBPM devices on the market have fulfilled independent validation criteria, there is a need for continuous monitoring of devices on the market, with information on validated recorders being distributed to healthcare providers and purchasers. The ESH has supported the establishment of a not-for-profit Web site to provide updated lists of validated BP-measuring devices (www.dableducational.org). Other Web sites such as that of the British Hypertension Society (www.bhsoc.org) also provide information on device validation.
The need to re-validate devices that undergo minor modification without alteration to the measurement algorithm has been repeatedly queried by manufacturers . The Writing Committee supports the device equivalence procedure proposed by dablEducational Trust . Manufacturers are requested to post statements of the equivalence of the measurement algorithm for different models on dedicated Web sites.
Device calibration: testing device accuracy in individual subjects
Electronic devices are unlikely to develop calibration errors because of the demonstrated stability of the electronic pressure transducers . If such a device generates a reading, it is therefore likely to be accurate. Repeated aberrant readings indicate malfunction and should dictate the need for calibration checks or replacement. Regular calibration over time is therefore not recommended but as other components, such as tubing and cuffs may deteriorate and affect accuracy, individual devices should nevertheless be periodically checked and their components replaced if needed.
Although it is known that for unexplained reasons oscillometric devices might not be accurate in some individuals, at present, there is no agreement on the need to test device accuracy against mercury sphygmomanometers in individual patients, when the device is first used. However, doing so might offer an opportunity for education and training of patients, who are often impressed by the higher readings in the doctor's office. Although such a procedure might not be very accurate, it could also be useful to check that measurements are performed correctly (including selection of proper cuff size).
Devices for HBPM must be easy to use, preferentially fully automated, with an easily readable digital display, and must be operated by a single push-button (Boxes 6 and 7). They should have sufficient memory to enable physicians to recall previously stored readings (i.e. at least 500 readings).
Built-in software for preliminary automated data analysis and interpretation may be useful. In particular, the devices providing whole-period averages following the recommended diagnostic schedule (see below) should be preferred. Other features that may be useful in some patients include acoustic signals during cuff inflation and deflation, systems for detection of arm or body movements or of irregular heart beats, indication of high BP values, calculation of separate morning and evening averages, double memory (for simultaneous use by two individuals in the same family), programmable alarms reminding users to take readings, AC/DC adaptor to save battery life in case of frequent use, external computer connectivity, possibility of printout, automated night-time measurements, possibility to select specific time periods for statistical analysis (e.g. before and after changing therapy).
Home blood pressure monitoring and telemedicine
HBP values are usually reported in handwritten logbooks, which are frequently inaccurate and/or illegible [53,69] and do not provide an immediate insight into the overall time course and control of BP. This may discourage physicians from using them in clinical decision making. The need for automated HBPM data storage, analysis and reporting functions has stimulated the development of HBP telemonitoring (HBPT) systems . HBPT is based on registration of BP data obtained at the patient's home and their transfer to a remote computer through telephone (stationary or mobile) or Internet connection. Automatically generated reports of these data aid the physician in making therapeutic decisions, which may be communicated to the patient without the need for additional clinic visits. Several HBPT systems are available on the market, with different modalities of data transmission and reporting, and additional features such as reminders of measurement and/or medication intake.
HBPT shares most advantages of traditional HBPM, while improving the quality of data reporting and facilitating their interpretation. It may also improve the control of BP and compliance with treatment  and be useful for faster identification of patients responding to treatment . Preliminary reports also suggest a possible usefulness of HBPT for self-titration of antihypertensive medication by patients . HBPT may also be valuable for comparing antihypertensive treatments in clinical trials . The main disadvantage of HBPT is the high cost of purchasing and maintaining the system, partly counterbalanced by a reduction in the costs of patients' management compared with usual care. This is of particular importance in the light of the possibility of HBPT being reimbursed by national healthcare systems. Other limitations of HBPT include the need for training and the requirement of a telephonic/Internet connection. Inclusion of HBPT in integrated home-care systems for cardiovascular monitoring may stimulate its further development, particularly in conditions that require close follow-up, such as chronic heart failure.
User procedures: frequency and timing of home blood pressure monitoring
Selection of the optimal schedule for HBPM should consider its relation with cardiovascular risk (‘outcome-based approach’) and its ability to provide a reliable and reproducible assessment of the ‘usual’ HBP of each individual (‘clinical approach’)  (Box 8).
In outcome studies [10–18,20–24], a wide variety of HBPM schedules have been used (Table 2). Irrespective of the monitoring schedule, HBPM is a powerful predictor of cardiovascular risk (see Home blood pressure monitoring and prognosis), even when only two [10,20] or three  HBP readings are obtained. However, when the monitoring time is extended over a few days and the number of readings increases up to 14, and possibly 25 , the prognostic value improves [10,23]. Moreover, single morning HBP measurements probably give an incomplete picture of the HBP because of significant differences between successive readings  and between morning and evening BP values [78,79], which may have different prognostic impact . Thus, to achieve the optimal prognostic power of HBPM, the average of at least 12 values, taken in the morning and the evening, should be used.
Short-term trials have investigated the optimal schedule on the basis of the reproducibility of HBP, its stability over time and its relationship with ABPM values. The reproducibility of HBP depends on the number of averaged HBP measurements , and its maximum level was achieved in different studies at five or six [80,81] up to 30  measurements over a few monitoring days, most of the stability being achieved over the first 2–5 days [77,79–82]. A 7-day schedule with duplicate morning and evening HBP measurements was thus suggested as appropriate for clinical pharmacology trials .
Even though HBP is known to be devoid of a white-coat effect [6,84,85], in several studies, HBP values on the initial monitoring day were shown to be higher and more unstable and the reproducibility of HBP was improved when they were discarded [12,23,77,82]. Moreover, the average HBP from the initial day does not identify differences in drug efficacy . These drawbacks of the initial day of HBPM persist in subsequent HBPM sessions in an individual patient.
The reliability of HBP was also verified by comparing it with average ABP values. Although some authors suggested that only a few readings may suffice to achieve best results , according to others, a large number (42 over 7 days) of heavily edited measurements are needed .
Recommended home blood pressure monitoring schedule
On the background of these observations, the optimal HBPM schedule to be used for decision making should represent the usual level of HBP, give a reproducible HBP level and have sufficient prognostic value . Based on the above data, to achieve this, a minimum of 12 measurements and up to 25 measurements over a few days might be desirable. The Writing Committee supports the previous suggestion by the ESH Working Group on BP Monitoring , according to which HBP should be monitored for 7 days, with at least two morning and two evening measurements. For clinical decision making, the average of all values should be used with the exception of the first day, which should be discarded.
This schedule should be used in the commencement phase, the treatment phase and the follow-up phase. In other words, it is advisable for the patient to monitor his/her HBP using this 7-day schedule immediately before each visit to the physician's office. Some debate on this issue is still going on, however [89,90]. No consensus was reached on whether and how HBP should be monitored in the remaining period, i.e. between visits. It should be considered that long-term BPM might lead to unnecessary and compulsive BP measurements in some patients. Moreover, the finding of isolated high BP readings may lead to inappropriate self-adjustment of drug dosage or unnecessary visits to the emergency department. Nevertheless, many experts believe that long-term HBPM might allow a closer assessment of the stability of HBP control, improve patients' involvement and compliance with treatment and maintain their BP measurement skills at an adequate level, as detailed in two later sections.
Diagnostic and therapeutic thresholds
Even though the association between BP and cardiovascular risk is continuous, it is crucial for clinical decision making to define the threshold values for HBPM above which hypertension should be diagnosed (diagnostic threshold). Another important problem is whether therapeutic targets for HBPM should also be defined, and if so, what they should be. There is worldwide consensus that the cut-off limits applicable for conventional sphygmomanometry cannot be directly extrapolated to HBPM, because studies on unselected populations [10–16,19,20,24,91] and hypertensive patients [18,21,38] have demonstrated that HBP is lower than OBP. The present recommendations on these thresholds are based on the evidence coming from meta-analyses [92,93], observational studies and clinical trials, and refer also to previous guidelines [3,4,6,94–102].
Review of evidence
In a meta-analysis of the aggregate data extracted from published articles, the thresholds were defined through the analysis of relative distributions of HBP and OBP values and identification of corresponding BP levels. Depending on the method used, the identified HBP thresholds were 137/89 mmHg (two SD cut-off), 135/86 mmHg (95th percentile cut-off), 129/84 mmHg (corresponding to OBP = 140/90 mmHg, regression method) and 125/79 mmHg (corresponding to OBP = 140/90 mmHg, percentile method) . In a meta-analysis of individual patient data, the 95th percentiles of HBP were 136/85 mmHg BP (morning), 139/86 mmHg (evening) and 137/85 mmHg (whole day) .
Several longitudinal studies in populations [10–16,19,20,24,91] or patient cohorts [18,21,38] have attempted to find a justification for diagnostic cut-off limits for the HBP in terms of mortality [10,11,19,20,91] or fatal and non-fatal endpoints [12,13,15,16,18,21,23–25,38]. Suggested thresholds differed slightly between the studies (Table 3) ranging between 125 and 138 mmHg for SBP and 83 and 85 for DBP [10,11,23,24,91]. Similar results were obtained in treated hypertensive patients . A couple of studies suggested that the HBP thresholds in high-risk patients might be lower than 135/85 mmHg [13,21].
Until now, only a few trials on the use of HBPM have been completed and published. In two of them (THOP and HOMERUS), antihypertensive drug treatment was adjusted based on either HBP or OBP, and the same threshold (140/90 mmHg) was used for both. The results of both these trials confirmed that the cut-off limit for the DBP should be lower on HBP than OBP measurement [103,104]. The HOMED-BP outcome trial, the results of which are not yet available, is aimed at defining therapeutic HBP targets by randomizing individuals to two groups with target HBP of 125–134/80–84 mmHg and below 125/80 mmHg [105,106]
Until now, there is only indirect evidence on operational thresholds in pregnancy . Reference thresholds for HBP in children and adolescents were also proposed . These issues are discussed in more detail later in this paper.
Proposal for diagnostic and therapeutic thresholds
The above evidence supports the idea that hypertension should be diagnosed by HBPM starting at BP levels of 135 mmHg SBP or 85 mmHg DBP in adults, older individuals and women (including pregnant women), at least until more evidence is available for special populations. Although the use of values below 120/80 mmHg and below 130/85 mmHg as optimal and normal, respectively, for HBPM has been proposed, the Writing Committee agreed that they should not be recommended until more prospective data are available.
The target levels of HBP to be attained on antihypertensive drug treatment are currently unknown, this issue being explored by the ongoing HOMED-BP study . However, the target HBP for therapy should logically be below the threshold used to diagnose hypertension, that is, it should be less than 135 mmHg for systolic and less than 85 mmHg for diastolic HBP. As recommended for the OBP , lower treatment HBP targets might be advisable in high-risk patients, such as those with diabetes mellitus, a history of stroke, coronary heart disease or renal disease. However, direct evidence supporting these lower targets is not yet available.
Even small gradients in the achieved OBP are known to significantly influence the risk of cardiovascular outcomes [109–112] and the reduction in OBP translates into a decrease in HBP, although the reduction in HBP is smaller than that of OBP. Based on the observed home-to-office ratios in the BP-lowering effect , a decrease in systolic HBP by 2 mmHg may be expected to provide similar relative risk reductions as a decrease in office SBP by 3 mmHg, that is, a 20% reduction in the incidence of stroke. It should thus be emphasized that even if the difficulties in attaining therapeutic goals  may be frustrating for patients and physicians, each mmHg reduction in HBP is important, as it contributes to the prevention of cardiovascular complications, especially in high-risk patients.
Diagnostic implication of home blood pressure monitoring in hypertension
As discussed above, there is agreement to use 135/85 mmHg as the cut-off point for diagnosing hypertension corresponding to an OBP of 140/90 mmHg. If a regression line is drawn to demonstrate the relationship between OBP and HBP, it is clear that, although there may be a good correlation between the two measurements, the scatter will be considerable. This means that each individual falls into one of the four categories defined in Fig. 1. Individuals with an OBP 140/90 mmHg or more and HBP 135/85 mmHg or more will be described as having sustained (uncontrolled) hypertension, whereas those with both measurements below these diagnostic thresholds can be considered normal (sustained normotension or controlled hypertension if treated). The phenomenon of ‘WCH’ [5,7,42,43], in which high BP values seen in a medical environment (i.e. OBP) normalize during out-of-office BP measurement, was demonstrated many years ago using ABPM  and later also became apparent using HBPM [85,114].
More recently, the term ‘masked hypertension’ has been coined to describe patients with normal OBP but high out-of-office readings (Fig. 1). Again, this was first studied with ABPM  but is equally apparent with HBPM .
The prevalence of these two conditions in the general population is relatively consistent in the literature (15–20% WCH and 10–15% masked hypertension [116,117]). Although most such information has been obtained using ABPM, HBPM has also provided similar estimates , even if the results obtained with the two techniques do not overlap completely [85,119].
A number of studies have addressed the issue of the prognostic implications of WCH and masked hypertension. The prognostic relevance of WCH is still debated, but it may be safely stated that, if anything, it increases cardiovascular risk only modestly . By contrast, masked hypertension has been consistently shown to be associated with elevated risk, close to that of patients with persistent hypertension in whom both office and out-of-office BP values are elevated [116,120].
Despite the obvious clinical relevance of WCH and masked hypertension, so far there is no agreement on the ideal clinical approach to these conditions in the absence of supporting evidence. Out-of-office BP measurement is by definition essential to their identification and, in fact, suspected WCH and masked hypertension are among the main indications for ABPM or HBPM [1,3,6].
Home blood pressure monitoring in the long-term follow-up of hypertension
An important application of HBPM lies in the possibility of its long-term use in the management of every patient on antihypertensive therapy [121,122], with the resultant reduction in the need to attend for medical check-ups  (Box 9). Several national and international guidelines [6,99–102] do recommend the use of HBPM for hypertension management.
Assessment of blood pressure control: white coat and masked hypertensions in treated hypertensive patients
HPBM has the ability to provide information about BP control outside the office, thereby allowing the identification of treated hypertensive patients with WCH and masked hypertension .
WCH (i.e. the presence of HBP control despite elevated OBP) is highly prevalent in treated hypertensive patients , meaning that many patients who appear to be refractory to treatment in the doctor's office may well have adequately controlled BP at home. Although all guidelines recommend the use of ABP measurements, in those patients, in order to confirm or reject the diagnosis of resistant hypertension , HBPM can also be useful.
The identification of treated patients with controlled OBP and uncontrolled out-of-office BP may be even more important because this condition appears to be very common (42–50% of patients with controlled OBP had elevated HBP in some studies [18,126]) and is associated with similar cardiovascular risk as sustained uncontrolled hypertension . This condition is commonly termed ‘masked hypertension’ as in the diagnostic approach to untreated patients, although the mechanisms responsible for this phenomenon may be different in treated than in untreated patients. Its high prevalence in treated patients may be explained partly by the fact that OBP is often taken at the time of the peak drug effect, whereas HBP can be taken at trough, leading to a discrepancy between these BP measurements which is particularly evident when short-acting drugs are used.
Considering the difficulties in identifying patients with WCH and masked hypertension in the clinic, ideally HBPM should be performed in all treated hypertensive patients, even if they have controlled OBP. The recommendation to perform HBPM is even stronger in patients likely to have masked hypertension [i.e. patients older than 60 years and with high normal systolic OBP (130–140 mmHg), smokers or male patients older than 70 years] , as well as in patients with high normal OBP who are at a high risk of developing cardiovascular disease (multiple risk factors, evidence of target organ damage, associated morbidity, such as diabetes mellitus or renal disease), and those with diagnosed cardiovascular disease.
Use of home blood pressure monitoring in improving adherence to treatment and blood pressure control
One of the most important causes of uncontrolled hypertension is poor adherence to therapy. In fact, success with lifestyle interventions in patients with chronic conditions is often improved by encouraging patients to become actively involved in their care. HBPM, being the BP measurement method that requires particular cooperation by the patient, may be particularly effective in favourably affecting patients' perceptions of their hypertension and thereby may encourage them to be compliant with lifestyle modifications and antihypertensive therapy. In fact, it was shown that the use of HBPM is associated with better compliance to treatment , which makes this approach a particularly valuable adjunct in patients with treatment-resistant hypertension due to poor compliance . Moreover, a meta-analysis of randomized controlled trials that compared HBPM with usual care showed that HBPM resulted in better BP control than usual BP measurements in the healthcare system , and this result could be observed earlier than with office readings .
Importantly, as documented by a recent survey, HBPM is increasingly accepted and utilized by primary care physicians not only to assess the response to antihypertensive therapy and the long-term follow-up of treated hypertensive patients but also to improve patient compliance .
Considering the difficulties in defining the characteristics of patients with discrepancies between OBP and HBP control, the prognostic importance of masked hypertension in treated hypertensive patients, and the likely benefits in terms of patient involvement and compliance with treatment, the Writing Committee recommends the use of HBPM in all patients with treated hypertension (Box 10).
Special applications of home blood pressure monitoring
During the past few years, there has been a renewed interest in measuring BP in children and adolescents following the recognition that apart from the presence of secondary hypertension, in most cases caused by renal diseases, essential hypertension is common in adolescents (Box 11). Furthermore, the long-term health risk for hypertensive children and adolescents can be substantial.
Hypertension in children has specific characteristics, including a particularly poor predictive value of OBP, use of population-based percentiles rather than single thresholds for hypertension diagnosis, association with a broad spectrum of underlying diseases, predominance of secondary hypertension in the early years of life, with increasing rate of essential hypertension in adolescence . Moreover, both WCH and masked hypertension have been described in children .
Similarly, as in the adult population, in children and adolescents also, BP variability, observer bias and the white-coat effect limit the reliability of office measurements . Because of this, ABPM has become an established instrument for the diagnosis of hypertension in this population . However, evidence supporting the accuracy of oscillometric devices in children is very limited (see www.dableducational.org).
The increasing availability of equipment for HBPM has led to increasing interest in regular HBP measurements, but the data on HBPM in children and adolescents remain scarce. In particular, the factors that have limited the use of HBPM in this population include very limited data about validation of HBP monitors, lack of established reference values, limited data about reproducibility, and difficulty in obtaining cooperation from children.
Among the few validation studies of oscillometric monitors in the paediatric age group, some produced successful results, whereas others failed to pass a validation protocol (see Appendix A, Suggested reading).
OBP in childhood and adolescents increases steadily during growth and maturation, and adolescence is a fast growth period during which body mass and BP change rapidly . For these reasons, reference BP values specific for sex, age and/or height have been introduced for children and adolescents by the Task Force For Blood Pressure in Children . However, in children and adolescents, daytime ABP, HBP or OBP may differ to a large extent, probably due to the high level of physical activity in this population . Interestingly, in younger children, OBP appears to be lower than HBP, and this difference is reduced with increasing age and disappears after the age of 12 years . So far, only one study has attempted to provide normal HBP values in a population aged from 6 to 18 years  (Table 4).
Reproducibility of HBPM in comparison with OBP and ABP was investigated in a recent study on children and adolescents . As had been shown previously in adults , HBPM was found to be more reproducible than OBP and as reproducible as ABP .
There are no recommendations regarding when and how frequently HBPM should be measured in children. In line with findings in adults [77,82], in children and adolescents, a short period of HBPM (duplicate morning and evening measurements on at least 3 days, preferably on 7 days) provides a reliable assessment of the level of BP at home .
In conclusion, although OBP measurement remains the recommended method for the evaluation of BP in children and adolescents, HBPM appears to have considerable potential for use in clinical practice and hypertension research in this population. However, more evidence is needed regarding its methodology and clinical utility.
There are several features of hypertension in elderly individuals which make the monitoring of BP out of physician's office particularly important in this population. First, the prevalence of WCH is higher in elderly hypertensive patients than in younger hypertensive patients . Second, elderly individuals are characterized by a more pronounced BP variability compared with younger individuals , which by itself may be associated with an elevated cardiovascular risk , especially when such high variability is related to an excessive BP surge in morning hours . Third, in elderly individuals, autoregulation of the circulation of target organs during excessive BP reduction is impaired and excessive antihypertensive medication targeting OBP can cause symptomatic hypotension, which may worsen treatment compliance.
Although ABPM appears the most suitable technique to diagnose the above problems, HBPM may also be a useful tool to cope with these features and achieve optimal individual 24-h BP control in the elderly individuals . The role of HBPM in elderly individuals (but also in other patients, e.g. those with obstructive sleep apnoea) might increase with the introduction of devices able to provide night-time BP measurements [142,143].
The data from large prospective studies and clinical trials using HBPM in the elderly individual are very limited. Therefore, until more evidence is available, the threshold of HBPM for diagnosis of hypertension and the target HBP level of antihypertensive medication in the elderly individual should be the same as in other adults, that is 135/85 mmHg.
In the elderly individual, it may be difficult to use HBPM because of physical and intellectual limitations. Integrated HBPM devices, with the ability to take multiple automated BP measurements and to provide automated storing and analysis of the data, should thus be preferred in this population, and the assistance of other persons (e.g. family members) may be necessary in some cases. Importantly, HBPM in this population should be measured both in the sitting and standing positions, whenever orthostatic hypotension is suspected.
The clinical evaluation of hypertension in obese individuals  is complicated by the fact that the discrepancies between office and out-of-office BPs are more common in this group than in the non-obese population. In fact, the severity of obesity seems to be associated with a higher prevalence of both WCH and masked hypertension, obesity being one of the main factors associated with a higher HBP relative to OBP [118,145].
Another important difficulty in BP measurement (both in the office and at home) in the obese individuals is related to inappropriate cuff sizes, which may importantly affect the accuracy of measurement. The use of a regular cuff may lead to an overestimation of BP in obese individuals. Although it is possible to adjust for cuff size after measuring arm circumference, by referring to standardized values, it is better and simpler to use the appropriate cuff . The appropriate cuff size in obese individuals depends not only on the arm circumference but also on its shape. A conical shaped arm, common in obese individuals, makes it difficult to fit the cuff to the arm, with a potential for inaccurate BP measurement. The use of wrist devices may help avoid these difficulties and represents a potential alternative for HBPM in obese individuals, but further investigation and technological improvement are needed.
Patients with arrhythmias
The use of HBPM in patients with arrhythmias raises special concerns. In atrial fibrillation or frequent supraventricular and ventricular extrasystoles, the stroke volume varies depending on the preceding pulse interval and causes a large variation of BP from beat to beat, often making an accurate BP measurement difficult or impossible. In atrial fibrillation, this phenomenon is more evident in patients without rate control than in those with rate control. Moreover, in patients with arrhythmias, the use of beta-blockers or other antiarrhythmic drugs may often be the cause of bradyarrhythmia, which may also affect the accuracy of measurement.
Generally, there is no universally accepted method of BP measurement in patients with arrhythmias, and BP devices vary greatly in their ability to measure BP accurately [147,148]. In particular, BP measurement is virtually impossible with oscillometric devices, whose software is, in most cases, unable to compute SBP and DBP values accurately, especially in case of atrial fibrillation, unless heart rate is adequately controlled by treatment. Research into new solutions is ongoing, but as yet no devices can be considered as validated in this setting. A potentially interesting development is the availability of HBPM devices with arrhythmia-detection algorithms, which may be useful as an early alert when arrhythmias occur . The diagnostic accuracy of these algorithms requires validation using appropriately designed protocols, however.
Because of the above problems with automated BP monitors, the auscultatory method remains a viable option for HBPM in patients with arrhythmias, if appropriately trained. Several aspects should be taken into account when auscultatory BP is measured in these patients. In patients with atrial fibrillation, SBP is frequently overestimated and DBP underestimated, because the first Korotkoff sound is not representative of SBP. However, this variability can be overcome if the deflation rate is no faster than 2 mmHg per heartbeat and more than three measurements are performed. In the presence of a bradyarrhythmia (i.e. the ventricular response lower than 40–45 beats/min) it is important that the deflation rate is slower than for normal heart rates, as an excessive deflation rate will lead to underestimation of SBP and overestimation of DBP. In summary, HBPM may sometimes be used in patients with arrhythmias, when the likelihood of HBPM results being affected by the rhythm disturbance is low. Devices with an arrhythmia detection function might be useful in this group of individuals but require further testing. In patients with frequent or persistent arrhythmias, HBPM should not be used as the sole diagnostic tool until a validated methodology for BP estimation in these patients is developed.
Home blood pressure monitoring in pregnancy
Although assessing hypertension in pregnancy, BP sampling errors, as found in current clinical practice, may often result in diagnostic errors. In a survey of all women with eclampsia in the UK, only just over half had both hypertension and proteinuria detected prior to their seizure, in spite of 85% being seen within a week of presenting. Although pre-eclampsia involves much more than hypertension, raised BP is a reliable way to identify this condition, and home BP surveillance, in addition to antenatal care, can only improve its detection.
HBPM, although at present not commonly practised in this setting, has considerable potential in improving the management of pregnant women. It can not only reduce the number of antenatal visits without increasing anxiety , but is also actually welcomed by women with previous pre-eclampsia, who are particularly anxious about having a recurrence.
There are no established thresholds or management algorithms for managing hypertension in pregnant patients with HBPM, although recent community guidelines have been established for visiting health professionals . The differences between HBP and OBP are likely to be similar to those of non-pregnant patients and must be considered when advising referral thresholds. Also, given the potential immediate health risks to both mother and baby, HBPM should be implemented and a mechanism for same-day self-referral must be in place to their local maternity unit or appropriate health professional.
HBPM is almost exclusively performed with oscillometric BP devices. There is a concern that only a few oscillometric BP monitors are available that have been shown to be accurate in pre-eclampsia, where the altered haemodynamics often result in the underestimation of BP. Therefore, only accurate devices should be recommended. However, few devices have been validated in pregnancy by methodologically acceptable studies (see Appendix A, Suggested reading) (Table 5). A tendency to underestimate BP, especially in pre-eclampsia, was observed, but the degree of error does not necessarily preclude their use in clinical practice. Some machines do, however, have a large unacceptable error, and the recommendation remains that each device intended for use in an obstetric population should be specifically evaluated.
As recommended for OBP, HBPM should also be performed with the woman seated or lying on her side at a 45° angle, with her arm at the level of the heart.
Home blood pressure monitoring in chronic renal failure
Patients with a decrease in glomerular filtration rate (GFR) are likely to have co-existing hypertension, including a reduced nocturnal dip in BP and not infrequently higher night-time than daytime BP levels [151–153]. This is a common finding also in patients undergoing haemodialysis and continuous ambulatory peritoneal dialysis [154,155] and after renal transplantation [156–158]. In addition to the renal disease itself, frequently used drugs in these patients (erythropoietin  and cyclosporine ) also contribute to an increase in the prevalence and severity of hypertension.
It has been clearly demonstrated that in patients with chronic renal disease, adequate BP control reduces the rate of decline in renal function , cardiovascular morbidity and mortality. Consequently, an accurate assessment of BP status is a key to the optimum management of patient with reduced renal function.
In this scenario, HBPM is a recommended tool to help obtain more reliable BP values in order to detect patients with uncontrolled hypertension. The better prognostic value of HBPM as compared with OBP has been recently demonstrated, in terms of prediction of composite cardiovascular events, ESRD or death, systolic HBP being an independent predictor for ESRD in patients with chronic renal failure [21,25].
Furthermore, in patients on haemodialysis, HBP, and not predialysis or postdialysis BP, shares the combination of high sensitivity and high specificity for the diagnosis of hypertension, using ABPM as a reference standard. HBP is also a better correlate of left ventricular hypertrophy in patients on haemodialysis compared with peridialysis BP .
In patients on haemodialysis, HBPM should be used to assess BP during the between-dialysis period. Although predialysis BP seems to be related to total body water and not the between-dialysis weight gain , postdialysis BP depends on ultrafiltration. Monitoring BP at home thus carries the potential to give us information useful to select the best dialysis conditions.
Finally, it should be mentioned that in ESRD patients, the accuracy of the oscillometric devices is reduced due to arterial stiffness, and only a few of them have been successfully validated in these patients 
Home blood pressure monitoring in patients with diabetes
Problems with accuracy of oscillometric HBPM devices due to arterial stiffness may be also found in patients with diabetes . Nonetheless, HBPM has been studied in these patients and has been noted both to be similar or superior to OBP in predicting ABPM measurements . The usefulness of HBPM in this population is particularly related to its ability to detect masked hypertension. Indeed, diabetic patients have a very high (47%) prevalence of masked hypertension, detected with HBPM, and are at a higher risk of developing brain and kidney damage [119,165–167]. Hence, out-of-office monitoring of BP should be performed in diabetic patients whose OBP is normal, particularly in treated patients, because of the possibility of obtaining information on trough BP levels.
Although no studies attempted to define specifically the treatment target for HBPM in the diabetic population, one study demonstrated that HBP was a strong and independent predictor of the deterioration of renal function in diabetic patients and that such deterioration was present at relatively low HBP levels . Based on these observations, it was suggested that this target should be lower than that of OBP .
Home blood pressure monitoring vs. ambulatory blood pressure monitoring
ABPM was the first out-of-office technique that was shown to improve significantly the management of hypertensive patients . However, ABPM is presently recommended in selected patients only, because of the cost of ABPM devices, the need for a trained clinic staff, and the interference with patients' usual activities [1,6]. HBPM shares several of the advantages of ABPM and is less expensive, which supports the recommendation for its extensive use in clinical practice [1,3]. Indeed, in the last ESH BP measurement guidelines , ABPM and HBPM were clearly proposed as synergic and not as alternative techniques, able to provide complementary information on BP in different conditions and over different periods. Although in some studies no statistically significant differences were found between HBPM and daytime ABPM [77,168], lower BP values with HBPM than with daytime ABPM were reported [169–171], particularly in children and adolescents .
Reproducibility and diagnostic value
Both HBPM and ABPM show similar reproducibility, which is better than that of OBP [82,172–174], although the correlation between them is not so high [88,170]. HBP tends to correlate better with 24-h ABP than with daytime or nocturnal ABP . Significant, although limited, correlation was also demonstrated between the white-coat effects based on HBPM and ABPM . Also, the prevalence of WCH and masked hypertension diagnosed using either ABPM or HBPM were similar in several studies [115,116,168]; however, in a direct comparison of these two methods, only half of the patients were defined as having masked hypertension on the basis of both ABPM and HBPM, whereas in the remaining ones, the diagnosis was made by one method but not by the other [115,116]. In addition, it should be pointed out that in the majority of patients in whom the diagnosis of masked hypertension was made with only one method, the disagreement between the two methods was small (<5 mmHg), suggesting that this discrepancy depended heavily on the fact that BP values were close to diagnostic cut-offs [103,168].
The notion that ABPM and HBPM may have different value in WCH diagnosis led to the proposal of an algorithm whereby HBPM was used in individuals, otherwise considered at low risk, with ‘office’ hypertension. If HBPM is normal, an ABPM should be ordered to confirm the diagnosis of WCH. The cost-effectiveness of such an approach has not been tested, but it was demonstrated that OBP and HBP may indicate sustained hypertension in almost 40% of patients who have WCH according to ABPM . Therefore, no firm recommendation can be made at this point as to the relative place of HBPM and ABPM in the diagnosis of WCH or masked hypertension. An individualized approach taking into account the patient's characteristics (BP values, cardiovascular risk, target organ damage) and availability of HBPM and ABPM seems a reasonable option. In case of disagreement between methods, ABPM should probably take precedence because of the huge amount of outcome data available for this technique.
Several, although not all , studies have documented that the average levels of HBP [22,116,177,178] and ABP [22,116,178,179] correlate with organ damage better than does OBP. Direct comparisons of ABPM and HBPM did not identify significant differences between them in terms of correlation with left ventricular mass index or microalbuminuria [25,28]. Also, WCH and masked hypertension diagnosed with either method have similar relationships with left ventricular mass index and wall thickness . The superiority of ABP over OBP in predicting risk of morbid events is well documented , although few published studies support a closer relationship of HBP compared with OBP with cardiovascular outcomes (see Home blood pressure monitoring and prognosis). The predictive value of selective and combined elevation in OBP, ABP and HBP for mortality was assessed in the PAMELA study: a selective elevation in HBP vs. ABP values or vice versa carried an increased risk. The overall ability to predict death, however, was not greater for HBP and ABP than for OBP .
Available data indicate thus that ABP has similar or higher prognostic value than HBP, in particular when considering the prognostic value of nocturnal ABP.
Blood pressure control by treatment
Studies comparing antihypertensive treatment based on ABP and HBP instead of OBP showed, in either case, less intensive drug treatment and less BP control with fairly similar costs [103,170]. These studies, however, were limited by use of the same normalcy thresholds for OBP and HBP. When treatment decisions driven either by ABPM or HBPM were directly compared, no difference in BP changes was seen . A relatively low (75%) agreement between ABPM and HBPM has been reported in the evaluation of poorly controlled hypertension, HBPM classifying a lower proportion of patients as WCH than ABPM .
The above considerations indicate that HBPM should be considered not as a substitute for but as a complement of ABP (Table 6) . From a clinical standpoint, obtaining information on either OBP, HBP and ABP may represent the ideal clinical procedure. Low sensitivity and positive predictive value (vs. ABPM) are important limitations for HBPM if it is to be considered as a screening test.
Home blood pressure monitoring: research applications
Given the availability of validated, fully automated oscillometric BP measuring devices, it becomes more and more attractive to include HBPM in the evaluation of the BP-lowering effects of antihypertensive drugs [4,125] (Box 12). HBPM has several advantages over OBP in this indication.
1. HBPM provides multiple BP readings, thereby improving the precision and the reproducibility of measurements compared with office readings [79,130,181]. The SD of the mean difference between two sets of measurements (an index of measurement stability) based on HBPM is about half as much as that derived from OBP readings .
2. Owing to its better accuracy and reproducibility, HBPM increases the statistical power of comparative studies, making it possible to minimize the number of patients to be included in clinical trials .
3. HBPM may be useful as a guide to initiate and titrate antihypertensive therapy in the research setting .
4. HBPM allows the identification of patients with WCH or masked hypertension, and therefore better defines the BP normalization rate achieved by various drug regimens [116,183,184].
5. The placebo effect, frequently observed when BP is conventionally measured in a clinic setting, is minimal or even absent using HBPM [80,130]. This facilitates greatly the design and the conduct of clinical trials.
6. HBPM offers the opportunity to assess the duration of action of antihypertensive drugs. This can be done by measuring BP at trough, before the morning dose, and again when the full effect of the drug is expected, for instance at midday or in the evening [141,185]. Based on these measurements, it is possible to calculate the morning: evening (M/E) ratio, which may provide similar information to the trough: peak ratio, an index widely used to reflect the duration of action of antihypertensive drugs [130,141].
7. HBPM can be carried out for weeks or months, providing valuable information on the BP changes occurring during the whole trial.
8. Implementing HBPM into clinical trials may be motivating for patients, thereby contributing to improved compliance and BP control .
The reliability of HBPM increases with the number of BP readings available for analysis [79,89], therefore, a proper schedule of monitoring should be implemented. To make the results of studies employing HBPM comparable, it is advisable that a standardized schedule is used, unless there are specific reasons to modify it. If the results of clinical studies are to be translated in practice, an identical schedule as recommended for a clinical setting should also be used in research (see above).
In clinical trials, only validated electronic BP monitors should be used, with preference for those with memory for storage of readings or for devices with a printout of BP values or data download on a PC, in order to prevent reporting bias [52,186]. For this reason, ideally, the same device should be used to measure BP at home and in the clinic setting.
This paper has summarized the information on the use of HBPM in clinical practice and research presently available in published papers. The large amount of new data available has required a substantial revision of the previous recommendations on the same topic issued in 2000 . While reviewing these data, heterogeneous data were often found. In fact, when considering HBPM, there are not only areas of convincing evidence but also areas of uncertainty in which more studies are still needed. Further progress in this field will be made possible by future research, taking advantage of the rapid development in technology of BP-measuring devices. Additional knowledge will be offered by the increasing amount of evidence provided by population studies and randomized trials on hypertension management, exploring the added value related to the information provided by HBPM.
Implementation of experts' recommendations on HBPM in clinical practice requires close interaction with general practitioners. Such an interaction is presently being aimed at in different countries, and should lead to a sharing of goals and methods of HBPM between scientists and general practitioners at a local level, aimed at favouring the largest possible diffusion of this approach. Finally, further progress in this field will require closer cooperation between scientists and manufacturers. On the one hand, scientists have to identify and propose the type of information that a given BP-measuring device should be able to provide to the clinician, whereas, on the other hand, manufacturers should be receptive to suggestions and translate them into new features for HBPM devices to make them more responsive to clinical needs, both in terms of hardware and software development.
This paper would be incomplete without a set of instructions for patients/users. This simple how-to-do set of information is being prepared and will be published as a separate paper.
When outlining the fields in which future research could be most useful, the following topics, already highlighted in the 2000 consensus document on HBPM, should be considered:
1. Development and production of an ‘adjustable cuff’, which may be applicable to all adult arms, in order to avoid the inaccuracy induced by miscuffing.
2. More attention to be paid to haemodynamic parameters other than BP, which are becoming important in cardiovascular evaluation, such as heart rate, pulse pressure, central BP and pulse wave velocity.
3. Application of a single international standard protocol for the validation of all BP-measuring devices must be encouraged to allow for comparison between studies performed in different places according to a similar methodology. This should be coupled with procedures to review the validation papers, to ensure their unbiased reliability.
4. Determination of HBPM reference values not only for SBP and DBP but also for heart rate and pulse pressure, which appear to be independently related to cardiovascular prognosis.
5. More prospective studies to evaluate the prognostic values of the proposed thresholds of HBPM normality.
6. Studies to determine the reference values of HBP and the diagnostic usefulness of HBPM in specific populations (children, pregnant woman, elderly individuals, patients with diabetes or CKD). These studies may be completed by the evaluation of the feasibility of HBPM and of device validity in these specific populations.
7. Specific studies to compare the prognostic values of OBP, HBP and ABP measurements are needed. These studies may use markers of target organ damage and progression of hypertension as endpoints in addition to, or instead of, mortality and morbidity. Evaluation of the prognostic impact of different HBPM protocols and the number and the frequency of measurements is also desirable.
8. Studies to determine the role of HBPM in resistant hypertension and its comparison with the role of OBP and ABP measurements are needed in order to define the appropriate management strategy.
9. Longitudinal studies to define the target value of HBP in treated hypertensive patients on a prognostic basis are needed.
Finally, the evidence gathered so far on the clinical value of HBPM in daily practice should promote reimbursement of the costs related to this approach by insurance companies as well as by public and private healthcare systems.
The Writing Committee is very grateful to
1. the European Society of Hypertension for its support and endorsement;
2. the Blood Pressure Monitoring Journal and the Journal of Hypertension for their contribution and sponsorships;
3. Microlife Ltd, Novartis France, Novartis Italy, Omron Japan Ltd, for their contribution and financial support;
4. Mariaconsuelo Valentini MD, Stefano Omboni MD, Licia Pietrobon PhD, Luca Grappiolo MSc, for their help in organizing the Consensus Meeting in Verbania.
Document reviewers: Denis L. Clement (Department of the Dean, Ghent University Hospital, Ghent, Belgium), Eamon Dolan (Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Cambridge, UK), Robert Fagard (Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, Belgium), Tine W. Hansen (Research Center for Prevention and Health, Copenhagen, Denmark), Jean-Michel Mallion (Service de Cardiologie et hypertension artérielle, CHU, Grenoble, France), Martin G. Myers (Division of Cardiology, Sunnybrook Health Sciences Centre, Toronto, Canada), Stefano Omboni (Italian Institute of Telemedicine, Varese, Italy), Mariaconsuelo Valentini (Department of Clinical Medicine and Prevention, University of Milano-Bicocca and Department of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy), Paolo Verdecchia (Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy), Ji-Guang Wang (Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University Medical School, China), William B. White (Department of Medicine, University of Connecticut School of Medicine, Farmington, USA).
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141 Menard J, Chatellier G, Day M, Vaur L. Self-measurement of blood pressure at home to evaluate drug effects by the trough: peak ratio. J Hypertens Suppl 1994; 12:S21–S25.
142 Shirasaki O, Yamashita S, Kawara S, Tagami K, Ishikawa J, Shimada K, et al
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143 Hosohata K, Kikuya M, Ohkubo T, Metoki H, Asayama K, Inoue R, et al
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144 Redon J. Hypertension in obesity. Nutr Metab Cardiovasc Dis 2001; 11:344–353.
145 Lurbe E, Invitti C, Torro I, Maronati A, Aguilar F, Sartorio A, et al
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146 Maxwell MH, Waks AU, Schroth PC, Karam M, Dornfeld LP. Error in blood-pressure measurement due to incorrect cuff size in obese patients. Lancet 1982; 2:33–36.
147 Stewart MJ, Gough K, Padfield PL. The accuracy of automated blood pressure measuring devices in patients with controlled atrial fibrillation. J Hypertens 1995; 13:297–300.
148 Jani B, Bulpitt CJ, Rajkumar C. Blood pressure measurement in patients with rate controlled atrial fibrillation using mercury sphygmomanometer and Omron HEM-750CP device in the clinic setting. J Hum Hypertens 2006; 20:543–545.
149 Ross-McGill H, Hewison J, Hirst J, Dowswell T, Holt A, Brunskill P, et al
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150 Milne F, Redman C, Walker J, Baker P, Bradley J, Cooper C, et al
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151 Timio M, Venanzi S, Lolli S, Lippi G, Verdura C, Monarca C, et al
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152 Redon J, Oliver V, Zaragoza MD, Galindo MJ. Ambulatory blood pressure during diseases of the kidney. Blood Press Monit 1999; 4:267–274.
153 Portaluppi F, Montanari L, Massari M, Di Chiara V, Capanna M. Loss of nocturnal decline of blood pressure in hypertension due to chronic renal failure. Am J Hypertens 1991; 4:20–26.
154 Luik AJ, Struijk DG, Gladziwa U, von Olden RW, von Hooff JP, de Leeuw PW, et al
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155 Cheigh JS, Serur D, Paguirigan M, Stenzel KH, Rubin A. How well is hypertension controlled in CAPD patients? Adv Perit Dial 1994; 10:55–58.
156 Gatzka CD, Schobel HP, Klingbeil AU, Neumayer HH, Schmieder RE. Normalization of circadian blood pressure profiles after renal transplantation. Transplantation 1995; 59:1270–1274.
157 Faria MS, Nunes JP, Ferraz JM, Fernandes J, Praca A, Pestana M, et al
. 24-h blood pressure profile early after renal transplantation. Rev Port Cardiol 1995; 14:227–231.
158 Lingens N, Dobos E, Lemmer B, Scharer K. Nocturnal blood pressure elevation in transplanted pediatric patients. Kidney Int Suppl 1996; 55:S175–S176.
159 Jones MA, Kingswood JC, Dallyn PE, Andrew M, Cheetham A, Burwood R, et al
. Changes in diurnal blood pressure variation and red cell and plasma volumes in patients with renal failure who develop erythropoietin-induced hypertension. Clin Nephrol 1995; 44:193–200.
160 Taler SJ, Textor SC, Canzanello VJ, Wilson DJ, Wiesner RH, Krom RA. Loss of nocturnal blood pressure fall after liver transplantation during immunosuppressive therapy. Am J Hypertens 1995; 8:598–605.
161 Lins RL, Elseviers M, Rogiers P, Van Hoeyweghen RJ, De Raedt H, Zachee P, et al
. Importance of volume factors in dialysis related hypertension. Clin Nephrol 1997; 48:29–33.
162 Thompson AM, Eguchi K, Reznik ME, Shah SS, Pickering TG. Validation of an oscillometric home blood pressure monitor in an end-stage renal disease population and the effect of arterial stiffness on its accuracy. Blood Press Monit 2007; 12:227–232.
163 Raptis AE, Spring MW, Viberti G. Comparison of blood pressure measurement methods in adult diabetics. Lancet 1997; 349:175–176.
164 Masding MG, Jones JR, Bartley E, Sandeman DD. Assessment of blood pressure in patients with Type 2 diabetes: comparison between home blood pressure monitoring, clinic blood pressure measurement and 24-h ambulatory blood pressure monitoring. Diabet Med 2001; 18:431–437.
165 Skrtic S, Niklason A, Leoo T, Hedner T. Risk factor identification and assessment in hypertension and diabetes (RIAHD) study. Blood Press 2006; 15:367–374.
166 Leitao CB, Canani LH, Kramer CK, Boza JC, Pinotti AF, Gross JL. Masked hypertension, urinary albumin excretion rate, and echocardiographic parameters in putatively normotensive type 2 diabetic patients. Diabetes Care 2007; 30:1255–1260.
167 Obara T, Ohkubo T, Kikuya M, Asayama K, Metoki H, Inoue R, et al
. The current status of home and office blood pressure control among hypertensive patients with diabetes mellitus: the Japan Home Versus Office Blood Pressure Measurement Evaluation (J-HOME) study. Diabetes Res Clin Pract 2006; 73:276–283.
168 Bayo J, Cos FX, Roca C, Dalfo A, Martin-Baranera MM, Albert B. Home blood pressure self-monitoring: diagnostic performance in white-coat hypertension. Blood Press Monit 2006; 11:47–52.
169 Mancia G, Sega R, Bravi C, De Venuto G, Valagussa F, Cesana G, et al
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170 Staessen JA, Byttebier G, Buntinx F, Celis H, O'Brien ET, Fagard R. Antihypertensive treatment based on conventional or ambulatory blood pressure measurement. A randomized controlled trial. Ambulatory Blood Pressure Monitoring and Treatment of Hypertension Investigators. JAMA 1997; 278:1065–1072.
171 Hond ED, Celis H, Fagard R, Keary L, Leeman M, O'Brien E, et al
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172 Denolle T. Comparison and reproducibility of 4 methods of indirect blood pressure measurement in moderate hypertension [in French]. Arch Mal Coeur Vaiss 1995; 88:1165–1170.
173 Brueren MM, van Limpt P, Schouten HJ, de Leeuw PW, van Ree JW. Is a series of blood pressure measurements by the general practitioner or the patient a reliable alternative to ambulatory blood pressure measurement? A study in general practice with reference to short-term and long-term between-visit variability. Am J Hypertens 1997; 10:879–885.
174 Palatini P, Mormino P, Canali C, Santonastaso M, De Venuto VG, Zanata G, et al
. Factors affecting ambulatory blood pressure reproducibility. Results of the HARVEST Trial. Hypertension and Ambulatory Recording Venetia Study. Hypertension 1994; 23:211–216.
175 Stergiou GS, Alamara CV, Skeva II, Mountokalakis TD. Diagnostic value of strategy for the detection of white coat hypertension based on ambulatory and home blood pressure monitoring. J Hum Hypertens 2004; 18:85–89.
176 Jula A, Puukka P, Karanko H. Multiple clinic and home blood pressure measurements versus ambulatory blood pressure monitoring. Hypertension 1999; 34:261–266.
177 Mule G, Caimi G, Cottone S, Nardi E, Andronico G, Piazza G, et al
. Value of home blood pressures as predictor of target organ damage in mild arterial hypertension. J Cardiovasc Risk 2002; 9:123–129.
178 Martinez MA, Sancho T, Garcia P, Moreno P, Rubio JM, Palau FJ, et al
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179 Verdecchia P, Clement D, Fagard R, Palatini P, Parati G. Blood Pressure Monitoring. Task force III: Target-organ damage, morbidity and mortality. Blood Press Monit 1999; 4:303–317.
180 Niiranen TJ, Kantola IM, Vesalainen R, Johansson J, Ruuska MJ. A comparison of home measurement and ambulatory monitoring of blood pressure in the adjustment of antihypertensive treatment. Am J Hypertens 2006; 19:468–474.
181 Mengden T, Binswanger B, Weisser B, Vetter W. An evaluation of self-measured blood pressure in a study with a calcium-channel antagonist versus a beta-blocker. Am J Hypertens 1992; 5:154–160.
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183 Stergiou GS, Efstathiou SP, Argyraki CK, Roussias LG, Mountokalakis TD. White coat effect in treated versus untreated hypertensive individuals: a case–control study using ambulatory and home blood pressure monitoring. Am J Hypertens 2004; 17:124–128.
184 Pickering TG, Gerin W, Schwartz AR. What is the white-coat effect and how should it be measured? Blood Press Monit 2002; 7:293–300.
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186 Myers MG. Reporting bias in self-measurement of blood pressure. Blood Press Monit 2001; 6:181–183.
Suggested reading to be posted on the Journal of Hypertension Website
1. Parati G, Bilo G, Mancia G. White coat effect and white coat hypertension: What do they mean? Cardiovasc Rev Rep 2003; 24:477–484
2. Ibrahim MM, Tarazi RC, Dustan HP, Gifford RW Jr. Electrocardiogram in evaluation of resistance to antihypertensive therapy. Arch Intern Med 1977; 137:1125–1129.
3. Kleinert HD, Harshfield GA, Pickering TG, Devereux RB, Sullivan PA, Marion RM, et al. What is the value of home blood pressure measurement in patients with mild hypertension? Hypertension 1984; 6:574–578.
4. Verdecchia P, et al. Reliability of home self-recorded arterial pressure in essential hypertension in relation to the stage of the disease. In: Germano G, editor. Blood pressure recording in the clinical management of hypertension. Rome: Ediziono Pozzi; 1985. pp. 40–42.
5. Asmar R. Proceedings from the First International Consensus Conference on Self-Blood Pressure Measurement. Blood Press Monit 2000; 5:91–92.
6. O'Brien E, De Gaudemaris R, Bobrie G, Agabiti Rosei E, Vaisse B, and the participants of the First International Consensus Conference on Blood Pressure Self-Measurement. Devices and validation. Blood Press Monit 2000; 5:93–100.
7. Staessen J, Thijs L, and the participants of the First International Consensus Conference on Blood Pressure Self-Measurement. Development of diagnostic thresholds for automated self-measurement of blood pressure in adults. Blood Press Monit 2000; 5:101–109.
8. Herpin D, Pickering T, Stergiou G, de Leeuw P, Germano G, and the participants of the First International Consensus Conference on Blood Pressure Self-Measurement. Clinical applications and diagnosis. Blood Press Monit 2000; 5:131–135.
9. Imai Y, Poncelet P, DeBuyzere M, Padfield PL, Van Montfrans GA, and the participants of the First International Consensus Conference on Blood Pressure Self-Measurement. Prognostic significance of self-measurements of blood pressure. Blood Press Monit 2000; 5:137–143.
1. Mancia G, Ferrari A, Gregorini L, Parati G, Pomidossi G, Bertinieri G, et al. Blood pressure and heart rate variabilities in normotensive and hypertensive human beings. Circ Res 1983; 53:96–104.
2. British Hypertension Society. Blood pressure measurement [CD-ROM] 1998. Available from BMJ Books, BMA House, Tavistock Square, London WC1H 9JR.
3. Société Française d'Hypertension Artérielle. La prise de la pression artérielle au cabinet médical [CD-ROM] 1998. Available from Société Française d'Hypertension Arteérielle.
4. O'Brien E, Petrie J, Littler WA, de Swiet M, Padfield PD, Dillon MJ, et al. Blood pressure measurement: recommendations of the British Hypertension Society, 3rd edn. London: BMJ Publishing Group; 1997.
5. Silverberg DS, Shemesh E, Jaina A. The unsupported arm: a cause of falsely raised blood pressure readings. BMJ 1977; 2:1331.
6. Grassi G, Foglia G, Dell'Oro R, Seravalle G, Boari S, Mancia G. Reproducibility of home blood pressure monitoring by a new oscillometric wrist device. J Hypertens 2001; 19(Suppl 2):22–23.
7. Myers M. Reporting bias in self-measurement of blood pressure. Blood Press Monit 2001; 6:181–183.
8. Krecke HJ, Lutkes P, Maiwald M. Patient assessment of self-measurement of blood pressure: results of a telephone survey in Germany. J Hypertens 1996; 14:323–326.
9. Patyna WD, Borsch B, Patyna M, Mitrovic V. Information deficits concerning blood pressure self-measurement. Dtsch Med Wochenschr 2004; 129:2466–2469.
10. Grim CM, Grim CE. A curriculum for the training and certification of blood pressure measurement for healthcare providers. Can J Cardiol 1995; 11 (Suppl H):38H–42H.
11. Lopez LM, Taylor JR. Home blood pressure monitoring: point-of-care testing. Ann Pharmacother 2004; 38:868–873.
12. The Cardiovascular Institute. Hypertension and self-blood pressure measurement [CD-ROM] 2002. Available from The Cardiovascular Institute, The Cardiovascular Institute, 21 bd Delessert, 75016, Paris, France.
13. O'Brien E. Ave atque vale: the centenary of clinical sphygmomanometry. Lancet 1996; 348:1569–1570.
14. O'Brien E. Will mercury manometers soon be obsolete? J Hum Hypertens 1995; 9:933–934.
15. O'Brien E. Will the millimetre of mercury be replaced by the kilopascal? J Hypertens 1998; 16:259–261.
16. O'Brien E, Atkins N, Staessen J. State of the market: a review of ambulatory blood pressure monitoring devices. Hypertension 1995; 26:835–842.
17. O'Brien E, Atkins N. Validation and reliability of blood pressure monitors. In: White W, editor. Blood pressure monitoring in cardiovascular medicine and therapeutics. US: Humana Press Inc.; 2007.
18. Association for the Advancement of Medical Instrumentation. American National Standard for electronic or automated sphygmomanometers. Washington DC: AAMI, 1987.
19. European Society of Hypertension: http://www.eshonline.org/newsletter/2002/Newsletter_nr12.pdf
20. British Hypertension Society: http://www.hyp.ac.uk/bhs/bp_monitors/automatic.htm
HBPM and telemedicine
1. Friedman RH, Kazis LE, Jette A, Smith MB, Stollerman J, Torgerson J, Carey K. A telecommunication system for monitoring and counseling patients with hypertension. Impact on medication adherence and blood pressure control. Am J Hypertens 1996; 9:285–292.
2. Parati G, Omboni S, Paintoni L, Andolfo S, Angioni L, Belforti S, et al. Telemonitoring of home blood pressure improves blood pressure control in hypertension. J Hypertens 2004; 22(Suppl 2):S137
1. Parati G, Ravogli A, Mutti E, Santucciu C, Omboni S, Mancia G. Ambulatory blood pressure monitoring in the evaluation of antihypertensive drugs. J Hypertens 1994; 12(Suppl 8):S9–S15.
2. Mancia G, Parati G. Ambulatory blood pressure monitoring and organ damage. Hypertension 2000; 36:894–900.
3. Trazzi S, Mutti E, Frattola A, Imholz BPM, Parati G, Mancia G. Reproducibility of noninvasive and intra-arterial blood pressure monitoring. Implications for studies on antihypertensive treatment. J Hypertens 1991; 9:115–119.
4. Parati G, Mutti E, Ravogli A, Trazzi S, Villani A, Mancia G. Advantages and disadvantages of noninvasive ambulatory blood pressure monitoring. J Hypertens 1990; 8(Suppl 6):S33–S38.
5. Garcia-Vera MP, Sanz J. How many self-measured blood pressure readings are needed to estimate hypertensive patients' ‘true’ blood pressure? J Behav Med 1999; 22:93–113.
6. Celis H, De Cort P, Fagard R, Thijs L, Staessen JA. For how many days should blood pressure be measured at home in older patients before steady levels are obtained? J Hum Hypertens 1997; 11:673–677.
7. Sega R, Cesana G, Milesi C, Grassi G, Zanchetti A, Mancia G. Ambulatory and home blood pressure normality in the elderly: data from the PAMELA population. Hypertension 1997; 30(Pt 1):1–6.
Diagnostic and therapeutic thresholds
1. Asia Pacific Cohort Studies Collaboration. Blood pressure indices and cardiovascular disease in the Asia Pacific region. A pooled analysis. Hypertension 2003; 42:69–75.
2. Verdecchia P, Reboldi G, Angeli A, Gattobigio R, Bentivoglio M, Thijs L, et al. Angiotensin-converting enzyme inhibitors and calcium channel blockers for coronary heart disease and stroke prevention. Hypertension 2005; 46:386–392.
3. Casas JP, Chua W, Loukogoergakis S, Vallance P, Smeeth L, D'Hingorani A, et al. Effects of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysis. Lancet 2005; 366:2026–2033.
4. Blood Pressure Lowering Treatment Trialists' Collaboration. Blood pressure dependent and independent effects of agents that inhibit the renin-angiotensin system. J Hypertens 2007; 25:951–958.
5. Staessen JA, Birkenhäger WH. Evidence that new antihypertensives are superior to older drugs. Lancet 2005; 366:869–871.
6. Staessen JA, Thijs L, Byttebier G, Clement D, O'Brien ET, Palatini P, et al. Determining the trough-to-peak ratio in parallel-group trials. Hypertension 1997; 29:659–667.
7. Medical Research Council Working Party. MRC trial of treatment of mild hypertension: principal results. BMJ 1985; 291:97–104.
8. Benediktsson R, Padfield PL. Maximising the benefit of treatment in mild hypertension: three simple steps to improve diagnostic accuracy. QJM 2004; 97:15–20.
1. Parati G, Ulian G, Sampieri L, Palatini P, Villani A, Vanasia A, et al., on behalf of the Study on Ambulatory Monitoring of Blood Pressure and Lisinopril Evaluation (SAMPLE) Study Group. Attenuation of the ‘white coat effect’ by antihypertensive treatment and its relationship to regression of target organ damage. Hypertension 2000; 35:614–620.
2. O'Brien, E. Unmasking hypertension. Hypertension 2005; 45:481–482.
3. Messerli FH, Coliga D. Masked hypertension and white coat hypertension: therapeutic navigation between Scylla and Charybdis. J Am Coll Cardiol 2005; 546:516–517.
4. Verberk WJ, Kroon AA, Kessels AGH, de Leeuw PW. Home blood pressure measurement: a systematic review. J Am Coll Cardiol 2005; 46:743–751.
5. Stewart MJ, Gough K, Reid M, Webb DJ, Padfield PL. White coat hypertension: a comparison of detection using ambulatory blood pressure monitoring or home monitoring of blood pressure. J Hypertens 1996; 14:1507.
6. Bjorklund K, Lind L, Zethelius B, Andren B, Lithell H. Isolated ambulatory hypertension predicts cardiovascular morbidity in elderly men. Circulation 2003; 107:1297–1302.
7. Llisterri JL, Gil VF, Rodriguez G, Orozco D, Garcia A, Merino J. Interest of home blood pressure measurements (HBPM) to establish degree of hypertensive control. Blood Press 2003; 12:220–224.
8. Julius S. Home blood pressure monitoring: advantages and limitations. J Hypertens 1991; 9(Suppl 3):S41–S47.
Special applications of HBPM: Children
1. Lauer RM, Anderson AR, Beaglehole R, Burns TL. Factors related to tracking of blood pressure in children. Hypertension 1984; 6:307–314.
2. Stergiou GS, Yiannes NG, Rarra VC. Validation of the Omron 705 IT oscillometric device for home blood pressure measurement in children and adolescents: The Arsakion School Study. Blood Press Monit 2006; 11:229–234.
3. Wong SN, Tz Sung RY, Leung LC. Validation of three oscillometric blood pressure devices against auscultatory mercury sphygmomanometer in children. Blood Press Monit 2006; 11:281–291.
4. Soergel M, Kirschstein M, Busch C, Danne T, Gellermann J, Holl R, et al. Oscillometric twenty-four-hour ambulatory blood pressure values in healthy children and adolescents: a multicenter trial including 1141 subjects. J Pediatr 1997; 130:178–184.
5. de Man SA, André JL, Bachmann HJ, Grobbee DE, Ibsen KK, Laaser U, Lippert P, Hofmann A. Blood pressure in childhood: pooled findings of six European studies. J Hypertens 1991; 9:109–114.
6. Wuhl E, Hadtstein C, Mehls O, Schaefer F; Escape Trial Group. Home, clinic, and ambulatory blood pressure monitoring in children with chronic renal failure. Pediatr Res. 2004; 55:492–497.
7. Bald M, Hoyer PF. Measurement of blood pressure at home: survey among pediatric nephrologists. Pediatr Nephrol 2001; 16:1058–1062.
8. Stergiou G, Christodoulakis G, Giovas P, Lourida P, Alamara C. Home blood pressure monitoring in children: how many measurements are needed? [abstract]. J Hypertens 2007; 26:S136.
9. Klahr S, Levy AD, Beck GJ. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. N Engl J Med 1994; 330:877–884.
10. Wingen AM, Fabian-Bach C, Schaefer F, Mehls O. Randomised multicentre study of a low-protein diet on the progression of chronic renal failure in children. European Study Group of Nutritional Treatment of Chronic Renal Failure in Childhood. Lancet 1997; 349:1117–1123.
Special applications of HBPM: Elderly people
1. Kario K. Clinician's manual on early morning risk management in hypertension. London: Science Press; 2004. pp. 1–56.
2. O'Sullivan C, Duggan J, Lyons S, Thornton J, Lee M, O'Brien E. Hypertensive target-organ damage in the very elderly. Hypertension 2003; 42:130–135.
3. Staessen JA, Richart T, Birkenhager WH. Less atherosclerosis and lower blood pressure for a meaningful life perspective with more brain. Hypertension 2007; 49:389–400.
4. Forette F, Seux ML, Staessen JA, Thijs L, Babarskiene MR, Babeanu S, et al., Systolic Hypertension in Europe Investigators. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002; 162:2046–2052.
5. Sakakura K, Ishikawa J, Okuno M, Shimada K, Kario K. Exaggerated ambulatory blood pressure variability is associated with cognitive dysfunction in the very elderly and quality of life in the younger elderly. Am J Hypertens 2007; 20:720–727.
Special applications of HBPM: HBPM in pregnancy
1. Waugh J, Habiba MA, Bosio P, Boyce T, Shennan A, Halligan AW. Patient initiated home blood pressure recordings are accurate in hypertensive pregnant women. Hypertens Pregnancy 2003; 22:93–97.
2. Brown MA, Buddle ML, Bennett M, Smith B, Morris R, Whitworth JA. Ambulatory blood pressure in pregnancy: comparison of the SpaceLabs 90207 and Accutracker II monitors with intraarterial recordings. Am J Obstet Gynecol 1995; 173:218–223.
3. Franx A, Van der Post JAM, van Montfrans GA, Bruinse HW. Comparison of an auscultatory versus an oscillometric ambulatory blood pressure monitor in normotensive, hypertensive and preeclamptic pregnancy. Hypertens Pregn 1997; 16:187–202.
4. Franx A, Elfering IM, Merkus HMWM, van Montfrans GA. Validation of automated blood pressure recording in pregnancy. Br J Obstet Gynaecol 1994; 101:66–69.
5. Gupta M, Shennan A, Halligan A, Taylor D, de Swiet M. Oscillometric blood pressure monitoring in pregnancy and preeclampsia. Br J Obstetr Gynaecol 1997; 104:350–355.
6. Golara M, Benedict A, Jones C, Randhawa M, Poston L, Shennan AH. Inflationary oscillometry provides accurate measurement of blood pressure in preeclampsia. Br J Obstet Gynaecol 2002; 109:1143–1147.
7. Kwek K, Chan YG, Tan KH, Yeo GS. Validation of an oscillometric electronic sphygmomanometer in an obstetric population. Am Heart J 1998; 11:978–982.
8. Modesti PA, Costoli A, Cecioni I, Toccafondi S, Carnemolla A, Serneri GGN. Clinical evaluation of the QuietTrak blood pressure recorder according to the protocol of the British Hypertension Society. Blood Press Monit 1996; 1:63–68.
9. Natarajan P, Shennan AH, Penny J, Halligan AW, de Swiet M, Anthony J. Comparison of auscultatory and oscillometric automated blood pressure monitors in the setting of preeclampsia. Am J Obstet Gynecol 1999; 181:1203–1210.
10. O'Brien E, Mee F, Atkins N, Halligan A, O'Malley K. Accuracy of the SpaceLabs 90207 ambulatory blood pressure measuring system in normotensive pregnant women determined by the British Hypertension Society protocol. J Hypertens 1993b; 11 (Suppl 5):S282–S283.
11. Penny JA, Shennan AH, Rushbrook J, Halligan AW, Taylor DJ, de Swiet M. Validation of the QuietTrak ambulatory blood pressure monitor for use in pregnancy. Hypertens Pregn 1996; 15:313–321.
12. Penny JA, Shennan AH, Halligan AW, Taylor DJ, de Swiet M, Anthony J. Blood pressure measurement in severe preeclampsia. Letter. Lancet 1997; 349:1518.
13. Reinders A, Cuckson AC, Jones CR, Poet R, O'Sullivan G, Shennan AH. Validation of the Welch Allyn ‘Vital Signs’ blood pressure measurement device in pregnancy and preeclampsia. Br J Obstet Gynaecol 2003; 110:134–138.
14. Reinders A, Cuckson AC, Lee J, Shennan AH. An accurate automated blood pressure device for use in pregnancy and preeclampsia: Microlife 3BTO-A. Br J Obstet Gynaecol. 2005; 112:915–200.
15. Shennan AH, Kissane J, de Swiet M. Validation of the SpaceLabs 90207 ambulatory blood pressure monitor for use in pregnancy. Br J Obstet Gynaecol 1993; 100:904–908.
16. Shennan AH, Halligan A, Gupta M, Taylor D, de Swiet M. Oscillometric blood pressure measurement in severe preeclampsia: validation of the SpaceLabs 90207. Br J Obstet Gynaecol 1996b; 103:171–173.
17. Quinn M. Automated blood pressure measurement devices: a potential source of morbidity and preeclampsia. Am J Obstet Gynecol 1994; 170:1303–1307.
18. Shennan AH, Waugh J. The measurement of blood pressure and proteinuria in pregnancy. Preeclampsia. vol. 21. London: RCOG Press; 2003. pp. 305–324.
Special applications of HBPM: HBPM in chronic renal failure
1. van der Borne Tielemans Ch, Collart F, Vanherweghem JL, Degaute JP. Twenty-four-hour blood pressure and heart rate patterns in chronic hemodialysis patients. Am J Kidney Dis 1993; 22:419–425.
2. Cottone S, Panepinto N, Vadala A, Zagarrigo C, Galione P, Volpe V, Cerasola G. Sympathetic overactivity and 24 h blood pressure pattern in hypertensives with chronic renal failure. Ren Fail 1995; 17:751–758.
3. Jones MA, Kingswood JC, Dallyn PE, Andrew M, Cheetham A, Burwood R, Sharpstone P. Changes in diurnal blood pressure variation and red cell and plasma volumes in patients with renal failure who develop erythropoietin induced hypertension. Clin Nephrol 1995; 44:193–200.
4. Farmer CK, Goldsmith DJ, Cox J, Dallyn P, Kingswood JC, Sharpstone P. An investigation of the effect of advancing uraemia, renal replacement therapy and renal transplantation on blood pressure diurnal variability. Nephrol Dial Transplant 1997; 12:2301–2307.
5. Chazot C, Charra B, Laurent G, Didier C, Vo Van C, Terrat JC, et al. Interdialysis blood pressure control by long haemodialysis sessions. Nephrol Dial Transplant 1995; 10:831–837.
6. Dionisio P, Valenti M, Bergia R, Caramello E, Stramignoni E, Berto IM, et al. Influence of the hydration state on blood pressure values in a group of patients on regular maintenance hemodialysis. Blood Purif 1997; 15:25–33.
7. Goldsmith DJ, Covic AC, Venning MC, Ackrill P. Ambulatory blood pressure monitoring in renal dialysis and transplant patients. Am J Kidney Dis 1997; 29:593–600.
8. Clausen P, Feldt Rasmussen B, Ladefoged J. Circadian variation of blood pressure in patients with chronic renal failure on continuous ambulatory peritoneal dialysis. Scand J Clin Lab Invest 1995; 55:193–200.
9. Nakamura I, Tsuzuki K, Ito S. Twenty four hour monitoring of blood pressure and heart rate in patients with chronic renal failure or renal transplant recipients: analysis by the cosinor method. Acta Paediatr Jpn 1995; 37:52–57.
10. Marx MA, Gardner SF, Ketel BL. Diurnal blood pressure variation in kidney pancreas transplant recipients. Am J Hypertens 1996; 9:823–827.
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