Built-in software for preliminary automated data analysis and interpretation may be useful. In particular, the devices providing whole-period averages following the recommended diagnostic schedule (see below) should be preferred. Other features that may be useful in some patients include acoustic signals during cuff inflation and deflation, systems for detection of arm or body movements or of irregular heart beats, indication of high BP values, calculation of separate morning and evening averages, double memory (for simultaneous use by two individuals in the same family), programmable alarms reminding users to take readings, AC/DC adaptor to save battery life in case of frequent use, external computer connectivity, possibility of printout, automated night-time measurements, possibility to select specific time periods for statistical analysis (e.g. before and after changing therapy).
HBP values are usually reported in handwritten logbooks, which are frequently inaccurate and/or illegible [53,69] and do not provide an immediate insight into the overall time course and control of BP. This may discourage physicians from using them in clinical decision making. The need for automated HBPM data storage, analysis and reporting functions has stimulated the development of HBP telemonitoring (HBPT) systems . HBPT is based on registration of BP data obtained at the patient's home and their transfer to a remote computer through telephone (stationary or mobile) or Internet connection. Automatically generated reports of these data aid the physician in making therapeutic decisions, which may be communicated to the patient without the need for additional clinic visits. Several HBPT systems are available on the market, with different modalities of data transmission and reporting, and additional features such as reminders of measurement and/or medication intake.
HBPT shares most advantages of traditional HBPM, while improving the quality of data reporting and facilitating their interpretation. It may also improve the control of BP and compliance with treatment  and be useful for faster identification of patients responding to treatment . Preliminary reports also suggest a possible usefulness of HBPT for self-titration of antihypertensive medication by patients . HBPT may also be valuable for comparing antihypertensive treatments in clinical trials . The main disadvantage of HBPT is the high cost of purchasing and maintaining the system, partly counterbalanced by a reduction in the costs of patients' management compared with usual care. This is of particular importance in the light of the possibility of HBPT being reimbursed by national healthcare systems. Other limitations of HBPT include the need for training and the requirement of a telephonic/Internet connection. Inclusion of HBPT in integrated home-care systems for cardiovascular monitoring may stimulate its further development, particularly in conditions that require close follow-up, such as chronic heart failure.
Selection of the optimal schedule for HBPM should consider its relation with cardiovascular risk (‘outcome-based approach’) and its ability to provide a reliable and reproducible assessment of the ‘usual’ HBP of each individual (‘clinical approach’)  (Box 8).
Short-term trials have investigated the optimal schedule on the basis of the reproducibility of HBP, its stability over time and its relationship with ABPM values. The reproducibility of HBP depends on the number of averaged HBP measurements , and its maximum level was achieved in different studies at five or six [80,81] up to 30  measurements over a few monitoring days, most of the stability being achieved over the first 2–5 days [77,79–82]. A 7-day schedule with duplicate morning and evening HBP measurements was thus suggested as appropriate for clinical pharmacology trials .
The reliability of HBP was also verified by comparing it with average ABP values. Although some authors suggested that only a few readings may suffice to achieve best results , according to others, a large number (42 over 7 days) of heavily edited measurements are needed .
On the background of these observations, the optimal HBPM schedule to be used for decision making should represent the usual level of HBP, give a reproducible HBP level and have sufficient prognostic value . Based on the above data, to achieve this, a minimum of 12 measurements and up to 25 measurements over a few days might be desirable. The Writing Committee supports the previous suggestion by the ESH Working Group on BP Monitoring , according to which HBP should be monitored for 7 days, with at least two morning and two evening measurements. For clinical decision making, the average of all values should be used with the exception of the first day, which should be discarded.
This schedule should be used in the commencement phase, the treatment phase and the follow-up phase. In other words, it is advisable for the patient to monitor his/her HBP using this 7-day schedule immediately before each visit to the physician's office. Some debate on this issue is still going on, however [89,90]. No consensus was reached on whether and how HBP should be monitored in the remaining period, i.e. between visits. It should be considered that long-term BPM might lead to unnecessary and compulsive BP measurements in some patients. Moreover, the finding of isolated high BP readings may lead to inappropriate self-adjustment of drug dosage or unnecessary visits to the emergency department. Nevertheless, many experts believe that long-term HBPM might allow a closer assessment of the stability of HBP control, improve patients' involvement and compliance with treatment and maintain their BP measurement skills at an adequate level, as detailed in two later sections.
Even though the association between BP and cardiovascular risk is continuous, it is crucial for clinical decision making to define the threshold values for HBPM above which hypertension should be diagnosed (diagnostic threshold). Another important problem is whether therapeutic targets for HBPM should also be defined, and if so, what they should be. There is worldwide consensus that the cut-off limits applicable for conventional sphygmomanometry cannot be directly extrapolated to HBPM, because studies on unselected populations [10–16,19,20,24,91] and hypertensive patients [18,21,38] have demonstrated that HBP is lower than OBP. The present recommendations on these thresholds are based on the evidence coming from meta-analyses [92,93], observational studies and clinical trials, and refer also to previous guidelines [3,4,6,94–102].
In a meta-analysis of the aggregate data extracted from published articles, the thresholds were defined through the analysis of relative distributions of HBP and OBP values and identification of corresponding BP levels. Depending on the method used, the identified HBP thresholds were 137/89 mmHg (two SD cut-off), 135/86 mmHg (95th percentile cut-off), 129/84 mmHg (corresponding to OBP = 140/90 mmHg, regression method) and 125/79 mmHg (corresponding to OBP = 140/90 mmHg, percentile method) . In a meta-analysis of individual patient data, the 95th percentiles of HBP were 136/85 mmHg BP (morning), 139/86 mmHg (evening) and 137/85 mmHg (whole day) .
Until now, only a few trials on the use of HBPM have been completed and published. In two of them (THOP and HOMERUS), antihypertensive drug treatment was adjusted based on either HBP or OBP, and the same threshold (140/90 mmHg) was used for both. The results of both these trials confirmed that the cut-off limit for the DBP should be lower on HBP than OBP measurement [103,104]. The HOMED-BP outcome trial, the results of which are not yet available, is aimed at defining therapeutic HBP targets by randomizing individuals to two groups with target HBP of 125–134/80–84 mmHg and below 125/80 mmHg [105,106]
Until now, there is only indirect evidence on operational thresholds in pregnancy . Reference thresholds for HBP in children and adolescents were also proposed . These issues are discussed in more detail later in this paper.
The above evidence supports the idea that hypertension should be diagnosed by HBPM starting at BP levels of 135 mmHg SBP or 85 mmHg DBP in adults, older individuals and women (including pregnant women), at least until more evidence is available for special populations. Although the use of values below 120/80 mmHg and below 130/85 mmHg as optimal and normal, respectively, for HBPM has been proposed, the Writing Committee agreed that they should not be recommended until more prospective data are available.
The target levels of HBP to be attained on antihypertensive drug treatment are currently unknown, this issue being explored by the ongoing HOMED-BP study . However, the target HBP for therapy should logically be below the threshold used to diagnose hypertension, that is, it should be less than 135 mmHg for systolic and less than 85 mmHg for diastolic HBP. As recommended for the OBP , lower treatment HBP targets might be advisable in high-risk patients, such as those with diabetes mellitus, a history of stroke, coronary heart disease or renal disease. However, direct evidence supporting these lower targets is not yet available.
Even small gradients in the achieved OBP are known to significantly influence the risk of cardiovascular outcomes [109–112] and the reduction in OBP translates into a decrease in HBP, although the reduction in HBP is smaller than that of OBP. Based on the observed home-to-office ratios in the BP-lowering effect , a decrease in systolic HBP by 2 mmHg may be expected to provide similar relative risk reductions as a decrease in office SBP by 3 mmHg, that is, a 20% reduction in the incidence of stroke. It should thus be emphasized that even if the difficulties in attaining therapeutic goals  may be frustrating for patients and physicians, each mmHg reduction in HBP is important, as it contributes to the prevention of cardiovascular complications, especially in high-risk patients.
As discussed above, there is agreement to use 135/85 mmHg as the cut-off point for diagnosing hypertension corresponding to an OBP of 140/90 mmHg. If a regression line is drawn to demonstrate the relationship between OBP and HBP, it is clear that, although there may be a good correlation between the two measurements, the scatter will be considerable. This means that each individual falls into one of the four categories defined in Fig. 1. Individuals with an OBP 140/90 mmHg or more and HBP 135/85 mmHg or more will be described as having sustained (uncontrolled) hypertension, whereas those with both measurements below these diagnostic thresholds can be considered normal (sustained normotension or controlled hypertension if treated). The phenomenon of ‘WCH’ [5,7,42,43], in which high BP values seen in a medical environment (i.e. OBP) normalize during out-of-office BP measurement, was demonstrated many years ago using ABPM  and later also became apparent using HBPM [85,114].
More recently, the term ‘masked hypertension’ has been coined to describe patients with normal OBP but high out-of-office readings (Fig. 1). Again, this was first studied with ABPM  but is equally apparent with HBPM .
The prevalence of these two conditions in the general population is relatively consistent in the literature (15–20% WCH and 10–15% masked hypertension [116,117]). Although most such information has been obtained using ABPM, HBPM has also provided similar estimates , even if the results obtained with the two techniques do not overlap completely [85,119].
A number of studies have addressed the issue of the prognostic implications of WCH and masked hypertension. The prognostic relevance of WCH is still debated, but it may be safely stated that, if anything, it increases cardiovascular risk only modestly . By contrast, masked hypertension has been consistently shown to be associated with elevated risk, close to that of patients with persistent hypertension in whom both office and out-of-office BP values are elevated [116,120].
Despite the obvious clinical relevance of WCH and masked hypertension, so far there is no agreement on the ideal clinical approach to these conditions in the absence of supporting evidence. Out-of-office BP measurement is by definition essential to their identification and, in fact, suspected WCH and masked hypertension are among the main indications for ABPM or HBPM [1,3,6].
An important application of HBPM lies in the possibility of its long-term use in the management of every patient on antihypertensive therapy [121,122], with the resultant reduction in the need to attend for medical check-ups  (Box 9). Several national and international guidelines [6,99–102] do recommend the use of HBPM for hypertension management.
HPBM has the ability to provide information about BP control outside the office, thereby allowing the identification of treated hypertensive patients with WCH and masked hypertension .
WCH (i.e. the presence of HBP control despite elevated OBP) is highly prevalent in treated hypertensive patients , meaning that many patients who appear to be refractory to treatment in the doctor's office may well have adequately controlled BP at home. Although all guidelines recommend the use of ABP measurements, in those patients, in order to confirm or reject the diagnosis of resistant hypertension , HBPM can also be useful.
The identification of treated patients with controlled OBP and uncontrolled out-of-office BP may be even more important because this condition appears to be very common (42–50% of patients with controlled OBP had elevated HBP in some studies [18,126]) and is associated with similar cardiovascular risk as sustained uncontrolled hypertension . This condition is commonly termed ‘masked hypertension’ as in the diagnostic approach to untreated patients, although the mechanisms responsible for this phenomenon may be different in treated than in untreated patients. Its high prevalence in treated patients may be explained partly by the fact that OBP is often taken at the time of the peak drug effect, whereas HBP can be taken at trough, leading to a discrepancy between these BP measurements which is particularly evident when short-acting drugs are used.
Considering the difficulties in identifying patients with WCH and masked hypertension in the clinic, ideally HBPM should be performed in all treated hypertensive patients, even if they have controlled OBP. The recommendation to perform HBPM is even stronger in patients likely to have masked hypertension [i.e. patients older than 60 years and with high normal systolic OBP (130–140 mmHg), smokers or male patients older than 70 years] , as well as in patients with high normal OBP who are at a high risk of developing cardiovascular disease (multiple risk factors, evidence of target organ damage, associated morbidity, such as diabetes mellitus or renal disease), and those with diagnosed cardiovascular disease.
One of the most important causes of uncontrolled hypertension is poor adherence to therapy. In fact, success with lifestyle interventions in patients with chronic conditions is often improved by encouraging patients to become actively involved in their care. HBPM, being the BP measurement method that requires particular cooperation by the patient, may be particularly effective in favourably affecting patients' perceptions of their hypertension and thereby may encourage them to be compliant with lifestyle modifications and antihypertensive therapy. In fact, it was shown that the use of HBPM is associated with better compliance to treatment , which makes this approach a particularly valuable adjunct in patients with treatment-resistant hypertension due to poor compliance . Moreover, a meta-analysis of randomized controlled trials that compared HBPM with usual care showed that HBPM resulted in better BP control than usual BP measurements in the healthcare system , and this result could be observed earlier than with office readings .
Importantly, as documented by a recent survey, HBPM is increasingly accepted and utilized by primary care physicians not only to assess the response to antihypertensive therapy and the long-term follow-up of treated hypertensive patients but also to improve patient compliance .
Considering the difficulties in defining the characteristics of patients with discrepancies between OBP and HBP control, the prognostic importance of masked hypertension in treated hypertensive patients, and the likely benefits in terms of patient involvement and compliance with treatment, the Writing Committee recommends the use of HBPM in all patients with treated hypertension (Box 10).
During the past few years, there has been a renewed interest in measuring BP in children and adolescents following the recognition that apart from the presence of secondary hypertension, in most cases caused by renal diseases, essential hypertension is common in adolescents (Box 11). Furthermore, the long-term health risk for hypertensive children and adolescents can be substantial.
Hypertension in children has specific characteristics, including a particularly poor predictive value of OBP, use of population-based percentiles rather than single thresholds for hypertension diagnosis, association with a broad spectrum of underlying diseases, predominance of secondary hypertension in the early years of life, with increasing rate of essential hypertension in adolescence . Moreover, both WCH and masked hypertension have been described in children .
Similarly, as in the adult population, in children and adolescents also, BP variability, observer bias and the white-coat effect limit the reliability of office measurements . Because of this, ABPM has become an established instrument for the diagnosis of hypertension in this population . However, evidence supporting the accuracy of oscillometric devices in children is very limited (see www.dableducational.org).
The increasing availability of equipment for HBPM has led to increasing interest in regular HBP measurements, but the data on HBPM in children and adolescents remain scarce. In particular, the factors that have limited the use of HBPM in this population include very limited data about validation of HBP monitors, lack of established reference values, limited data about reproducibility, and difficulty in obtaining cooperation from children.
Among the few validation studies of oscillometric monitors in the paediatric age group, some produced successful results, whereas others failed to pass a validation protocol (see Appendix A, Suggested reading).
OBP in childhood and adolescents increases steadily during growth and maturation, and adolescence is a fast growth period during which body mass and BP change rapidly . For these reasons, reference BP values specific for sex, age and/or height have been introduced for children and adolescents by the Task Force For Blood Pressure in Children . However, in children and adolescents, daytime ABP, HBP or OBP may differ to a large extent, probably due to the high level of physical activity in this population . Interestingly, in younger children, OBP appears to be lower than HBP, and this difference is reduced with increasing age and disappears after the age of 12 years . So far, only one study has attempted to provide normal HBP values in a population aged from 6 to 18 years  (Table 4).
Reproducibility of HBPM in comparison with OBP and ABP was investigated in a recent study on children and adolescents . As had been shown previously in adults , HBPM was found to be more reproducible than OBP and as reproducible as ABP .
There are no recommendations regarding when and how frequently HBPM should be measured in children. In line with findings in adults [77,82], in children and adolescents, a short period of HBPM (duplicate morning and evening measurements on at least 3 days, preferably on 7 days) provides a reliable assessment of the level of BP at home .
In conclusion, although OBP measurement remains the recommended method for the evaluation of BP in children and adolescents, HBPM appears to have considerable potential for use in clinical practice and hypertension research in this population. However, more evidence is needed regarding its methodology and clinical utility.
There are several features of hypertension in elderly individuals which make the monitoring of BP out of physician's office particularly important in this population. First, the prevalence of WCH is higher in elderly hypertensive patients than in younger hypertensive patients . Second, elderly individuals are characterized by a more pronounced BP variability compared with younger individuals , which by itself may be associated with an elevated cardiovascular risk , especially when such high variability is related to an excessive BP surge in morning hours . Third, in elderly individuals, autoregulation of the circulation of target organs during excessive BP reduction is impaired and excessive antihypertensive medication targeting OBP can cause symptomatic hypotension, which may worsen treatment compliance.
Although ABPM appears the most suitable technique to diagnose the above problems, HBPM may also be a useful tool to cope with these features and achieve optimal individual 24-h BP control in the elderly individuals . The role of HBPM in elderly individuals (but also in other patients, e.g. those with obstructive sleep apnoea) might increase with the introduction of devices able to provide night-time BP measurements [142,143].
The data from large prospective studies and clinical trials using HBPM in the elderly individual are very limited. Therefore, until more evidence is available, the threshold of HBPM for diagnosis of hypertension and the target HBP level of antihypertensive medication in the elderly individual should be the same as in other adults, that is 135/85 mmHg.
In the elderly individual, it may be difficult to use HBPM because of physical and intellectual limitations. Integrated HBPM devices, with the ability to take multiple automated BP measurements and to provide automated storing and analysis of the data, should thus be preferred in this population, and the assistance of other persons (e.g. family members) may be necessary in some cases. Importantly, HBPM in this population should be measured both in the sitting and standing positions, whenever orthostatic hypotension is suspected.
Another important difficulty in BP measurement (both in the office and at home) in the obese individuals is related to inappropriate cuff sizes, which may importantly affect the accuracy of measurement. The use of a regular cuff may lead to an overestimation of BP in obese individuals. Although it is possible to adjust for cuff size after measuring arm circumference, by referring to standardized values, it is better and simpler to use the appropriate cuff . The appropriate cuff size in obese individuals depends not only on the arm circumference but also on its shape. A conical shaped arm, common in obese individuals, makes it difficult to fit the cuff to the arm, with a potential for inaccurate BP measurement. The use of wrist devices may help avoid these difficulties and represents a potential alternative for HBPM in obese individuals, but further investigation and technological improvement are needed.
The use of HBPM in patients with arrhythmias raises special concerns. In atrial fibrillation or frequent supraventricular and ventricular extrasystoles, the stroke volume varies depending on the preceding pulse interval and causes a large variation of BP from beat to beat, often making an accurate BP measurement difficult or impossible. In atrial fibrillation, this phenomenon is more evident in patients without rate control than in those with rate control. Moreover, in patients with arrhythmias, the use of beta-blockers or other antiarrhythmic drugs may often be the cause of bradyarrhythmia, which may also affect the accuracy of measurement.
Generally, there is no universally accepted method of BP measurement in patients with arrhythmias, and BP devices vary greatly in their ability to measure BP accurately [147,148]. In particular, BP measurement is virtually impossible with oscillometric devices, whose software is, in most cases, unable to compute SBP and DBP values accurately, especially in case of atrial fibrillation, unless heart rate is adequately controlled by treatment. Research into new solutions is ongoing, but as yet no devices can be considered as validated in this setting. A potentially interesting development is the availability of HBPM devices with arrhythmia-detection algorithms, which may be useful as an early alert when arrhythmias occur . The diagnostic accuracy of these algorithms requires validation using appropriately designed protocols, however.
Because of the above problems with automated BP monitors, the auscultatory method remains a viable option for HBPM in patients with arrhythmias, if appropriately trained. Several aspects should be taken into account when auscultatory BP is measured in these patients. In patients with atrial fibrillation, SBP is frequently overestimated and DBP underestimated, because the first Korotkoff sound is not representative of SBP. However, this variability can be overcome if the deflation rate is no faster than 2 mmHg per heartbeat and more than three measurements are performed. In the presence of a bradyarrhythmia (i.e. the ventricular response lower than 40–45 beats/min) it is important that the deflation rate is slower than for normal heart rates, as an excessive deflation rate will lead to underestimation of SBP and overestimation of DBP. In summary, HBPM may sometimes be used in patients with arrhythmias, when the likelihood of HBPM results being affected by the rhythm disturbance is low. Devices with an arrhythmia detection function might be useful in this group of individuals but require further testing. In patients with frequent or persistent arrhythmias, HBPM should not be used as the sole diagnostic tool until a validated methodology for BP estimation in these patients is developed.
Although assessing hypertension in pregnancy, BP sampling errors, as found in current clinical practice, may often result in diagnostic errors. In a survey of all women with eclampsia in the UK, only just over half had both hypertension and proteinuria detected prior to their seizure, in spite of 85% being seen within a week of presenting. Although pre-eclampsia involves much more than hypertension, raised BP is a reliable way to identify this condition, and home BP surveillance, in addition to antenatal care, can only improve its detection.
HBPM, although at present not commonly practised in this setting, has considerable potential in improving the management of pregnant women. It can not only reduce the number of antenatal visits without increasing anxiety , but is also actually welcomed by women with previous pre-eclampsia, who are particularly anxious about having a recurrence.
There are no established thresholds or management algorithms for managing hypertension in pregnant patients with HBPM, although recent community guidelines have been established for visiting health professionals . The differences between HBP and OBP are likely to be similar to those of non-pregnant patients and must be considered when advising referral thresholds. Also, given the potential immediate health risks to both mother and baby, HBPM should be implemented and a mechanism for same-day self-referral must be in place to their local maternity unit or appropriate health professional.
HBPM is almost exclusively performed with oscillometric BP devices. There is a concern that only a few oscillometric BP monitors are available that have been shown to be accurate in pre-eclampsia, where the altered haemodynamics often result in the underestimation of BP. Therefore, only accurate devices should be recommended. However, few devices have been validated in pregnancy by methodologically acceptable studies (see Appendix A, Suggested reading) (Table 5). A tendency to underestimate BP, especially in pre-eclampsia, was observed, but the degree of error does not necessarily preclude their use in clinical practice. Some machines do, however, have a large unacceptable error, and the recommendation remains that each device intended for use in an obstetric population should be specifically evaluated.
As recommended for OBP, HBPM should also be performed with the woman seated or lying on her side at a 45° angle, with her arm at the level of the heart.
Patients with a decrease in glomerular filtration rate (GFR) are likely to have co-existing hypertension, including a reduced nocturnal dip in BP and not infrequently higher night-time than daytime BP levels [151–153]. This is a common finding also in patients undergoing haemodialysis and continuous ambulatory peritoneal dialysis [154,155] and after renal transplantation [156–158]. In addition to the renal disease itself, frequently used drugs in these patients (erythropoietin  and cyclosporine ) also contribute to an increase in the prevalence and severity of hypertension.
It has been clearly demonstrated that in patients with chronic renal disease, adequate BP control reduces the rate of decline in renal function , cardiovascular morbidity and mortality. Consequently, an accurate assessment of BP status is a key to the optimum management of patient with reduced renal function.
In this scenario, HBPM is a recommended tool to help obtain more reliable BP values in order to detect patients with uncontrolled hypertension. The better prognostic value of HBPM as compared with OBP has been recently demonstrated, in terms of prediction of composite cardiovascular events, ESRD or death, systolic HBP being an independent predictor for ESRD in patients with chronic renal failure [21,25].
Furthermore, in patients on haemodialysis, HBP, and not predialysis or postdialysis BP, shares the combination of high sensitivity and high specificity for the diagnosis of hypertension, using ABPM as a reference standard. HBP is also a better correlate of left ventricular hypertrophy in patients on haemodialysis compared with peridialysis BP .
In patients on haemodialysis, HBPM should be used to assess BP during the between-dialysis period. Although predialysis BP seems to be related to total body water and not the between-dialysis weight gain , postdialysis BP depends on ultrafiltration. Monitoring BP at home thus carries the potential to give us information useful to select the best dialysis conditions.
Finally, it should be mentioned that in ESRD patients, the accuracy of the oscillometric devices is reduced due to arterial stiffness, and only a few of them have been successfully validated in these patients 
Problems with accuracy of oscillometric HBPM devices due to arterial stiffness may be also found in patients with diabetes . Nonetheless, HBPM has been studied in these patients and has been noted both to be similar or superior to OBP in predicting ABPM measurements . The usefulness of HBPM in this population is particularly related to its ability to detect masked hypertension. Indeed, diabetic patients have a very high (47%) prevalence of masked hypertension, detected with HBPM, and are at a higher risk of developing brain and kidney damage [119,165–167]. Hence, out-of-office monitoring of BP should be performed in diabetic patients whose OBP is normal, particularly in treated patients, because of the possibility of obtaining information on trough BP levels.
Although no studies attempted to define specifically the treatment target for HBPM in the diabetic population, one study demonstrated that HBP was a strong and independent predictor of the deterioration of renal function in diabetic patients and that such deterioration was present at relatively low HBP levels . Based on these observations, it was suggested that this target should be lower than that of OBP .
ABPM was the first out-of-office technique that was shown to improve significantly the management of hypertensive patients . However, ABPM is presently recommended in selected patients only, because of the cost of ABPM devices, the need for a trained clinic staff, and the interference with patients' usual activities [1,6]. HBPM shares several of the advantages of ABPM and is less expensive, which supports the recommendation for its extensive use in clinical practice [1,3]. Indeed, in the last ESH BP measurement guidelines , ABPM and HBPM were clearly proposed as synergic and not as alternative techniques, able to provide complementary information on BP in different conditions and over different periods. Although in some studies no statistically significant differences were found between HBPM and daytime ABPM [77,168], lower BP values with HBPM than with daytime ABPM were reported [169–171], particularly in children and adolescents .
Both HBPM and ABPM show similar reproducibility, which is better than that of OBP [82,172–174], although the correlation between them is not so high [88,170]. HBP tends to correlate better with 24-h ABP than with daytime or nocturnal ABP . Significant, although limited, correlation was also demonstrated between the white-coat effects based on HBPM and ABPM . Also, the prevalence of WCH and masked hypertension diagnosed using either ABPM or HBPM were similar in several studies [115,116,168]; however, in a direct comparison of these two methods, only half of the patients were defined as having masked hypertension on the basis of both ABPM and HBPM, whereas in the remaining ones, the diagnosis was made by one method but not by the other [115,116]. In addition, it should be pointed out that in the majority of patients in whom the diagnosis of masked hypertension was made with only one method, the disagreement between the two methods was small (<5 mmHg), suggesting that this discrepancy depended heavily on the fact that BP values were close to diagnostic cut-offs [103,168].
The notion that ABPM and HBPM may have different value in WCH diagnosis led to the proposal of an algorithm whereby HBPM was used in individuals, otherwise considered at low risk, with ‘office’ hypertension. If HBPM is normal, an ABPM should be ordered to confirm the diagnosis of WCH. The cost-effectiveness of such an approach has not been tested, but it was demonstrated that OBP and HBP may indicate sustained hypertension in almost 40% of patients who have WCH according to ABPM . Therefore, no firm recommendation can be made at this point as to the relative place of HBPM and ABPM in the diagnosis of WCH or masked hypertension. An individualized approach taking into account the patient's characteristics (BP values, cardiovascular risk, target organ damage) and availability of HBPM and ABPM seems a reasonable option. In case of disagreement between methods, ABPM should probably take precedence because of the huge amount of outcome data available for this technique.
Available data indicate thus that ABP has similar or higher prognostic value than HBP, in particular when considering the prognostic value of nocturnal ABP.
Studies comparing antihypertensive treatment based on ABP and HBP instead of OBP showed, in either case, less intensive drug treatment and less BP control with fairly similar costs [103,170]. These studies, however, were limited by use of the same normalcy thresholds for OBP and HBP. When treatment decisions driven either by ABPM or HBPM were directly compared, no difference in BP changes was seen . A relatively low (75%) agreement between ABPM and HBPM has been reported in the evaluation of poorly controlled hypertension, HBPM classifying a lower proportion of patients as WCH than ABPM .
The above considerations indicate that HBPM should be considered not as a substitute for but as a complement of ABP (Table 6) . From a clinical standpoint, obtaining information on either OBP, HBP and ABP may represent the ideal clinical procedure. Low sensitivity and positive predictive value (vs. ABPM) are important limitations for HBPM if it is to be considered as a screening test.
Given the availability of validated, fully automated oscillometric BP measuring devices, it becomes more and more attractive to include HBPM in the evaluation of the BP-lowering effects of antihypertensive drugs [4,125] (Box 12). HBPM has several advantages over OBP in this indication.
1. HBPM provides multiple BP readings, thereby improving the precision and the reproducibility of measurements compared with office readings [79,130,181]. The SD of the mean difference between two sets of measurements (an index of measurement stability) based on HBPM is about half as much as that derived from OBP readings .
2. Owing to its better accuracy and reproducibility, HBPM increases the statistical power of comparative studies, making it possible to minimize the number of patients to be included in clinical trials .
3. HBPM may be useful as a guide to initiate and titrate antihypertensive therapy in the research setting .
4. HBPM allows the identification of patients with WCH or masked hypertension, and therefore better defines the BP normalization rate achieved by various drug regimens [116,183,184].
5. The placebo effect, frequently observed when BP is conventionally measured in a clinic setting, is minimal or even absent using HBPM [80,130]. This facilitates greatly the design and the conduct of clinical trials.
6. HBPM offers the opportunity to assess the duration of action of antihypertensive drugs. This can be done by measuring BP at trough, before the morning dose, and again when the full effect of the drug is expected, for instance at midday or in the evening [141,185]. Based on these measurements, it is possible to calculate the morning: evening (M/E) ratio, which may provide similar information to the trough: peak ratio, an index widely used to reflect the duration of action of antihypertensive drugs [130,141].
7. HBPM can be carried out for weeks or months, providing valuable information on the BP changes occurring during the whole trial.
8. Implementing HBPM into clinical trials may be motivating for patients, thereby contributing to improved compliance and BP control .
The reliability of HBPM increases with the number of BP readings available for analysis [79,89], therefore, a proper schedule of monitoring should be implemented. To make the results of studies employing HBPM comparable, it is advisable that a standardized schedule is used, unless there are specific reasons to modify it. If the results of clinical studies are to be translated in practice, an identical schedule as recommended for a clinical setting should also be used in research (see above).
In clinical trials, only validated electronic BP monitors should be used, with preference for those with memory for storage of readings or for devices with a printout of BP values or data download on a PC, in order to prevent reporting bias [52,186]. For this reason, ideally, the same device should be used to measure BP at home and in the clinic setting.
This paper has summarized the information on the use of HBPM in clinical practice and research presently available in published papers. The large amount of new data available has required a substantial revision of the previous recommendations on the same topic issued in 2000 . While reviewing these data, heterogeneous data were often found. In fact, when considering HBPM, there are not only areas of convincing evidence but also areas of uncertainty in which more studies are still needed. Further progress in this field will be made possible by future research, taking advantage of the rapid development in technology of BP-measuring devices. Additional knowledge will be offered by the increasing amount of evidence provided by population studies and randomized trials on hypertension management, exploring the added value related to the information provided by HBPM.
Implementation of experts' recommendations on HBPM in clinical practice requires close interaction with general practitioners. Such an interaction is presently being aimed at in different countries, and should lead to a sharing of goals and methods of HBPM between scientists and general practitioners at a local level, aimed at favouring the largest possible diffusion of this approach. Finally, further progress in this field will require closer cooperation between scientists and manufacturers. On the one hand, scientists have to identify and propose the type of information that a given BP-measuring device should be able to provide to the clinician, whereas, on the other hand, manufacturers should be receptive to suggestions and translate them into new features for HBPM devices to make them more responsive to clinical needs, both in terms of hardware and software development.
This paper would be incomplete without a set of instructions for patients/users. This simple how-to-do set of information is being prepared and will be published as a separate paper.
When outlining the fields in which future research could be most useful, the following topics, already highlighted in the 2000 consensus document on HBPM, should be considered:
1. Development and production of an ‘adjustable cuff’, which may be applicable to all adult arms, in order to avoid the inaccuracy induced by miscuffing.
2. More attention to be paid to haemodynamic parameters other than BP, which are becoming important in cardiovascular evaluation, such as heart rate, pulse pressure, central BP and pulse wave velocity.
3. Application of a single international standard protocol for the validation of all BP-measuring devices must be encouraged to allow for comparison between studies performed in different places according to a similar methodology. This should be coupled with procedures to review the validation papers, to ensure their unbiased reliability.
4. Determination of HBPM reference values not only for SBP and DBP but also for heart rate and pulse pressure, which appear to be independently related to cardiovascular prognosis.
5. More prospective studies to evaluate the prognostic values of the proposed thresholds of HBPM normality.
6. Studies to determine the reference values of HBP and the diagnostic usefulness of HBPM in specific populations (children, pregnant woman, elderly individuals, patients with diabetes or CKD). These studies may be completed by the evaluation of the feasibility of HBPM and of device validity in these specific populations.
7. Specific studies to compare the prognostic values of OBP, HBP and ABP measurements are needed. These studies may use markers of target organ damage and progression of hypertension as endpoints in addition to, or instead of, mortality and morbidity. Evaluation of the prognostic impact of different HBPM protocols and the number and the frequency of measurements is also desirable.
8. Studies to determine the role of HBPM in resistant hypertension and its comparison with the role of OBP and ABP measurements are needed in order to define the appropriate management strategy.
9. Longitudinal studies to define the target value of HBP in treated hypertensive patients on a prognostic basis are needed.
Finally, the evidence gathered so far on the clinical value of HBPM in daily practice should promote reimbursement of the costs related to this approach by insurance companies as well as by public and private healthcare systems.
1. the European Society of Hypertension for its support and endorsement;
2. the Blood Pressure Monitoring Journal and the Journal of Hypertension for their contribution and sponsorships;
3. Microlife Ltd, Novartis France, Novartis Italy, Omron Japan Ltd, for their contribution and financial support;
4. Mariaconsuelo Valentini MD, Stefano Omboni MD, Licia Pietrobon PhD, Luca Grappiolo MSc, for their help in organizing the Consensus Meeting in Verbania.
Document reviewers: Denis L. Clement (Department of the Dean, Ghent University Hospital, Ghent, Belgium), Eamon Dolan (Cambridge University Hospitals NHS Foundation Trust, Addenbrookes Hospital, Cambridge, UK), Robert Fagard (Hypertension and Cardiovascular Rehabilitation Unit, Faculty of Medicine, University of Leuven, Belgium), Tine W. Hansen (Research Center for Prevention and Health, Copenhagen, Denmark), Jean-Michel Mallion (Service de Cardiologie et hypertension artérielle, CHU, Grenoble, France), Martin G. Myers (Division of Cardiology, Sunnybrook Health Sciences Centre, Toronto, Canada), Stefano Omboni (Italian Institute of Telemedicine, Varese, Italy), Mariaconsuelo Valentini (Department of Clinical Medicine and Prevention, University of Milano-Bicocca and Department of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy), Paolo Verdecchia (Department of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy), Ji-Guang Wang (Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital, Shanghai Jiaotong University Medical School, China), William B. White (Department of Medicine, University of Connecticut School of Medicine, Farmington, USA).
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Suggested reading to be posted on the Journal of Hypertension Website
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8. Herpin D, Pickering T, Stergiou G, de Leeuw P, Germano G, and the participants of the First International Consensus Conference on Blood Pressure Self-Measurement. Clinical applications and diagnosis. Blood Press Monit 2000; 5:131–135.
9. Imai Y, Poncelet P, DeBuyzere M, Padfield PL, Van Montfrans GA, and the participants of the First International Consensus Conference on Blood Pressure Self-Measurement. Prognostic significance of self-measurements of blood pressure. Blood Press Monit 2000; 5:137–143.
1. Mancia G, Ferrari A, Gregorini L, Parati G, Pomidossi G, Bertinieri G, et al. Blood pressure and heart rate variabilities in normotensive and hypertensive human beings. Circ Res 1983; 53:96–104.
2. British Hypertension Society. Blood pressure measurement [CD-ROM] 1998. Available from BMJ Books, BMA House, Tavistock Square, London WC1H 9JR.
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19. European Society of Hypertension: http://www.eshonline.org/newsletter/2002/Newsletter_nr12.pdf
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HBPM and telemedicine
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2. Parati G, Omboni S, Paintoni L, Andolfo S, Angioni L, Belforti S, et al. Telemonitoring of home blood pressure improves blood pressure control in hypertension. J Hypertens 2004; 22(Suppl 2):S137
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5. Garcia-Vera MP, Sanz J. How many self-measured blood pressure readings are needed to estimate hypertensive patients' ‘true’ blood pressure? J Behav Med 1999; 22:93–113.
6. Celis H, De Cort P, Fagard R, Thijs L, Staessen JA. For how many days should blood pressure be measured at home in older patients before steady levels are obtained? J Hum Hypertens 1997; 11:673–677.
7. Sega R, Cesana G, Milesi C, Grassi G, Zanchetti A, Mancia G. Ambulatory and home blood pressure normality in the elderly: data from the PAMELA population. Hypertension 1997; 30(Pt 1):1–6.
Diagnostic and therapeutic thresholds
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1. Parati G, Ulian G, Sampieri L, Palatini P, Villani A, Vanasia A, et al., on behalf of the Study on Ambulatory Monitoring of Blood Pressure and Lisinopril Evaluation (SAMPLE) Study Group. Attenuation of the ‘white coat effect’ by antihypertensive treatment and its relationship to regression of target organ damage. Hypertension 2000; 35:614–620.
2. O'Brien, E. Unmasking hypertension. Hypertension 2005; 45:481–482.
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Special applications of HBPM: Children
1. Lauer RM, Anderson AR, Beaglehole R, Burns TL. Factors related to tracking of blood pressure in children. Hypertension 1984; 6:307–314.
2. Stergiou GS, Yiannes NG, Rarra VC. Validation of the Omron 705 IT oscillometric device for home blood pressure measurement in children and adolescents: The Arsakion School Study. Blood Press Monit 2006; 11:229–234.
3. Wong SN, Tz Sung RY, Leung LC. Validation of three oscillometric blood pressure devices against auscultatory mercury sphygmomanometer in children. Blood Press Monit 2006; 11:281–291.
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6. Wuhl E, Hadtstein C, Mehls O, Schaefer F; Escape Trial Group. Home, clinic, and ambulatory blood pressure monitoring in children with chronic renal failure. Pediatr Res. 2004; 55:492–497.
7. Bald M, Hoyer PF. Measurement of blood pressure at home: survey among pediatric nephrologists. Pediatr Nephrol 2001; 16:1058–1062.
8. Stergiou G, Christodoulakis G, Giovas P, Lourida P, Alamara C. Home blood pressure monitoring in children: how many measurements are needed? [abstract]. J Hypertens 2007; 26:S136.
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Special applications of HBPM: Elderly people
1. Kario K. Clinician's manual on early morning risk management in hypertension. London: Science Press; 2004. pp. 1–56.
2. O'Sullivan C, Duggan J, Lyons S, Thornton J, Lee M, O'Brien E. Hypertensive target-organ damage in the very elderly. Hypertension 2003; 42:130–135.
3. Staessen JA, Richart T, Birkenhager WH. Less atherosclerosis and lower blood pressure for a meaningful life perspective with more brain. Hypertension 2007; 49:389–400.
4. Forette F, Seux ML, Staessen JA, Thijs L, Babarskiene MR, Babeanu S, et al., Systolic Hypertension in Europe Investigators. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med 2002; 162:2046–2052.
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Special applications of HBPM: HBPM in pregnancy
1. Waugh J, Habiba MA, Bosio P, Boyce T, Shennan A, Halligan AW. Patient initiated home blood pressure recordings are accurate in hypertensive pregnant women. Hypertens Pregnancy 2003; 22:93–97.
2. Brown MA, Buddle ML, Bennett M, Smith B, Morris R, Whitworth JA. Ambulatory blood pressure in pregnancy: comparison of the SpaceLabs 90207 and Accutracker II monitors with intraarterial recordings. Am J Obstet Gynecol 1995; 173:218–223.
3. Franx A, Van der Post JAM, van Montfrans GA, Bruinse HW. Comparison of an auscultatory versus an oscillometric ambulatory blood pressure monitor in normotensive, hypertensive and preeclamptic pregnancy. Hypertens Pregn 1997; 16:187–202.
4. Franx A, Elfering IM, Merkus HMWM, van Montfrans GA. Validation of automated blood pressure recording in pregnancy. Br J Obstet Gynaecol 1994; 101:66–69.
5. Gupta M, Shennan A, Halligan A, Taylor D, de Swiet M. Oscillometric blood pressure monitoring in pregnancy and preeclampsia. Br J Obstetr Gynaecol 1997; 104:350–355.
6. Golara M, Benedict A, Jones C, Randhawa M, Poston L, Shennan AH. Inflationary oscillometry provides accurate measurement of blood pressure in preeclampsia. Br J Obstet Gynaecol 2002; 109:1143–1147.
7. Kwek K, Chan YG, Tan KH, Yeo GS. Validation of an oscillometric electronic sphygmomanometer in an obstetric population. Am Heart J 1998; 11:978–982.
8. Modesti PA, Costoli A, Cecioni I, Toccafondi S, Carnemolla A, Serneri GGN. Clinical evaluation of the QuietTrak blood pressure recorder according to the protocol of the British Hypertension Society. Blood Press Monit 1996; 1:63–68.
9. Natarajan P, Shennan AH, Penny J, Halligan AW, de Swiet M, Anthony J. Comparison of auscultatory and oscillometric automated blood pressure monitors in the setting of preeclampsia. Am J Obstet Gynecol 1999; 181:1203–1210.
10. O'Brien E, Mee F, Atkins N, Halligan A, O'Malley K. Accuracy of the SpaceLabs 90207 ambulatory blood pressure measuring system in normotensive pregnant women determined by the British Hypertension Society protocol. J Hypertens 1993b; 11 (Suppl 5):S282–S283.
11. Penny JA, Shennan AH, Rushbrook J, Halligan AW, Taylor DJ, de Swiet M. Validation of the QuietTrak ambulatory blood pressure monitor for use in pregnancy. Hypertens Pregn 1996; 15:313–321.
12. Penny JA, Shennan AH, Halligan AW, Taylor DJ, de Swiet M, Anthony J. Blood pressure measurement in severe preeclampsia. Letter. Lancet 1997; 349:1518.
13. Reinders A, Cuckson AC, Jones CR, Poet R, O'Sullivan G, Shennan AH. Validation of the Welch Allyn ‘Vital Signs’ blood pressure measurement device in pregnancy and preeclampsia. Br J Obstet Gynaecol 2003; 110:134–138.
14. Reinders A, Cuckson AC, Lee J, Shennan AH. An accurate automated blood pressure device for use in pregnancy and preeclampsia: Microlife 3BTO-A. Br J Obstet Gynaecol. 2005; 112:915–200.
15. Shennan AH, Kissane J, de Swiet M. Validation of the SpaceLabs 90207 ambulatory blood pressure monitor for use in pregnancy. Br J Obstet Gynaecol 1993; 100:904–908.
16. Shennan AH, Halligan A, Gupta M, Taylor D, de Swiet M. Oscillometric blood pressure measurement in severe preeclampsia: validation of the SpaceLabs 90207. Br J Obstet Gynaecol 1996b; 103:171–173.
17. Quinn M. Automated blood pressure measurement devices: a potential source of morbidity and preeclampsia. Am J Obstet Gynecol 1994; 170:1303–1307.
18. Shennan AH, Waugh J. The measurement of blood pressure and proteinuria in pregnancy. Preeclampsia. vol. 21. London: RCOG Press; 2003. pp. 305–324.
Special applications of HBPM: HBPM in chronic renal failure
1. van der Borne Tielemans Ch, Collart F, Vanherweghem JL, Degaute JP. Twenty-four-hour blood pressure and heart rate patterns in chronic hemodialysis patients. Am J Kidney Dis 1993; 22:419–425.
2. Cottone S, Panepinto N, Vadala A, Zagarrigo C, Galione P, Volpe V, Cerasola G. Sympathetic overactivity and 24 h blood pressure pattern in hypertensives with chronic renal failure. Ren Fail 1995; 17:751–758.
3. Jones MA, Kingswood JC, Dallyn PE, Andrew M, Cheetham A, Burwood R, Sharpstone P. Changes in diurnal blood pressure variation and red cell and plasma volumes in patients with renal failure who develop erythropoietin induced hypertension. Clin Nephrol 1995; 44:193–200.
4. Farmer CK, Goldsmith DJ, Cox J, Dallyn P, Kingswood JC, Sharpstone P. An investigation of the effect of advancing uraemia, renal replacement therapy and renal transplantation on blood pressure diurnal variability. Nephrol Dial Transplant 1997; 12:2301–2307.
5. Chazot C, Charra B, Laurent G, Didier C, Vo Van C, Terrat JC, et al. Interdialysis blood pressure control by long haemodialysis sessions. Nephrol Dial Transplant 1995; 10:831–837.
6. Dionisio P, Valenti M, Bergia R, Caramello E, Stramignoni E, Berto IM, et al. Influence of the hydration state on blood pressure values in a group of patients on regular maintenance hemodialysis. Blood Purif 1997; 15:25–33.
7. Goldsmith DJ, Covic AC, Venning MC, Ackrill P. Ambulatory blood pressure monitoring in renal dialysis and transplant patients. Am J Kidney Dis 1997; 29:593–600.
8. Clausen P, Feldt Rasmussen B, Ladefoged J. Circadian variation of blood pressure in patients with chronic renal failure on continuous ambulatory peritoneal dialysis. Scand J Clin Lab Invest 1995; 55:193–200.
9. Nakamura I, Tsuzuki K, Ito S. Twenty four hour monitoring of blood pressure and heart rate in patients with chronic renal failure or renal transplant recipients: analysis by the cosinor method. Acta Paediatr Jpn 1995; 37:52–57.
10. Marx MA, Gardner SF, Ketel BL. Diurnal blood pressure variation in kidney pancreas transplant recipients. Am J Hypertens 1996; 9:823–827.
11. Hohage H, Bruckner D, Arlt M, Buchholz B, Zidek W, Spieker C. Influence of cyclosporine A and FK506 on 24 h blood pressure monitoring in kidney transplant recipients. Clin Nephrol 1996; 45:342–344.
12. Schwertfeger E, Keller E, Grotz W, Schollmeyer P, Rump LC. Pharmacokinetic profile of cyclosporine A after conversion to Sandimmun Optoral: influence on ambulatory blood pressure in renal transplant patients. Clin Nephrol 1996; 45:349–351.
HBPM versus ABPM
1. Divisón JA, Puras A, Aguilera M, Sanchis C, Artigao LM, Carrión L, et al. Home self-measurements of blood pressure and relationship with diagnosis of hypertension and target organ damage: comparative study with ambulatory monitoring. Med Clin (Barcelona) 2000; 115:730–735.
2. Mengden T, Battig B, Vetter W. Self-measurement of blood pressure improves the accuracy and reduces the number of subjects in clinical trials. J Hypertens 1991; 9(Suppl 6):S336–S337.
3. Pickering TG. Self monitoring of blood pressure. In: Ambulatory monitoring and blood pressure variability (part 1). London: Science Press; 1990. p. 8.5.
4. Longo D, Dorigatti F, Palatini P. Masked hypertension in adults. Blood Press Monit 2005; 10:307–310.
5. Mancia G, Carugo S, Grassi G, Lanzarotti A, Schiavina R, Cesana G, Sega R. Prevalence of left ventricular hypertrophy in hypertensive patients without and with blood pressure control: data from the PAMELA population. Pressioni Arteriose Monitorate E Loro Associazioni. Hypertension 2002; 39:744–749.
6. Stergiou GS. Ambulatory or home blood pressure monitoring for treatment adjustment? Am J Hypertens 2006; 19:475–476.
7. Nordmann A, Frach B, Walker T, Martina B, Battegay E. Comparison of self-reported home blood pressure measurements with automatically stored values and ambulatory blood pressure. Blood Press 2000; 9:200–205.