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Prevention of electrocardiographic left ventricular remodeling by the angiotensin receptor blocker olmesartan in patients with type 2 diabetes

Raff, Ulrikea; Ott, Christiana; Ruilope, Luis M.b,c; Menne, Jand; Haller, Hermannd; Schmieder, Roland E.a

doi: 10.1097/HJH.0000000000000313

Objective: To assess the ability of olmesartan (OLM) to prevent or delay left ventricular remodeling and hypertrophy in patients with type 2 diabetes.

Methods: This prespecified ECG substudy of Randomised OlmesArtan and Diabetes MicroAlbuminuria Prevention (ROADMAP), which compared OLM with placebo, assessed the signs of left ventricular remodeling in patients with a 12-lead ECG at baseline and after at least 2 years. Cornell voltage QRS duration product (primary objective), Cornell voltage index and Sokolow–Lyon index were assessed.

Results: In total, 9418 ECG recordings and 1513 patients from ROADMAP were analyzed (placebo, n = 736; OLM, n = 777). Quartiles defined by baseline Cornell voltage QRS duration product were assessed and the proportion of patients in the highest quartile (≥200 mV*ms) increased from 24.0 to 26.5% in the placebo group and decreased from 25.5 to 22.3% in the OLM group [odds ratio (OR) 0.598 (95% confidence interval [CI] 0.440–0.813); P = 0.0011]. The OR did not change after adjustment for baseline parameters. By the end of study, 38.7% of patients in the placebo group and 34.7% in the OLM group shifted from a lower to a higher quartile or remained in the highest quartile of Cornell voltage QRS duration product [OR 0.797 (95% CI 0.637–0.996); P = 0.0465]. This translated into a 20.3% risk reduction with OLM and suggested OLM attenuated the progression of left ventricular remodeling versus placebo.

Conclusion: OLM substantially delayed the development of left ventricular remodeling in type 2 diabetes. This effect was not explained by the differences in blood pressure control. Thus, OLM delayed the onset of microalbuminuria, as well as the ECG signs of cardiac structural adaptation in type 2 diabetes.

aDepartment of Nephrology and Hypertension, University Hospital of the University Erlangen-Nürnberg, Erlangen, Germany

bHypertension Unit, Hospital 12 de Octubre

cDepartment of Preventive Medicine and Public Health, Universidad Autónoma, Madrid, Spain

dDepartment of Nephrology and Hypertension, Medical School Hannover, Hannover, Germany

Correspondence to Dr med. Roland E. Schmieder, Professor, Department of Nephrology and Hypertension, Clinical Research Center, University Hospital Erlangen, Ulmenweg 18, 91054 Erlangen, Germany. Tel: +49 9131 853 6245; fax: +49 9131 853 6215; e-mail:

Abbreviations: ACEIs, angiotensin-converting enzyme inhibitors; AHT, antihypertensive therapy; ARBs, angiotensin receptor blockers; BP, blood pressure; eGFR, estimated glomerular filtration rate; OLM, olmesartan 40 mg; ROADMAP, Randomised OlmesArtan and Diabetes MicroAlbuminuria Prevention study

Received 5 February, 2014

Revised 18 June, 2014

Accepted 18 June, 2014

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© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins