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Oxidized low-density lipoprotein in postmenopausal women

Kork, Felixa; Jankowski, Verab; Just, Alexander R.c; Pfeilschifter, Johannesd; Tepel, Martine; Zidek, Walterb; Jankowski, Joachimb

doi: 10.1097/HJH.0000000000000197
ORIGINAL PAPERS: Blood vessels

Background: Oxidized low-density lipoprotein (oxLDL) leads to atherosclerosis and cardiovascular disease, the most frequent causes of death worldwide. After menopause, lipid and lipoprotein metabolism changes and women are at greater risk of cardiovascular disease compared to fertile women. The aim of this study was to determine the prevalence of serum oxLDL in postmenopausal women and to identify possible associations of clinical and laboratory features with oxLDL in these patients.

Method: After clinical examination and completing a clinical questionnaire, an ultrasound examination of both carotid arteries was conducted and blood was drawn from 533 postmenopausal women. oxLDL concentration was determined using proton NMR spectroscopy.

Results: Oxidized LDL was detected in 12.4% (95% confidence interval 9.7–15.5) of postmenopausal women with a median of 0.18 mg/dl (interquartile range 0.10–0.43). Although intima-media thickness did not differ, postmenopausal women with serous oxLDL had more often atherosclerotic plaques compared to women without oxLDL (6/66 vs. 0/467; P < 0.01). Higher concentrations of high-density lipoprotein, impaired glucose intolerance, and DBP were independently associated with the occurrence of oxLDL. If oxLDL was present, higher high-density lipoprotein and glucose intolerance were associated with higher concentrations of oxLDL. In contrast, higher blood urea concentrations were associated with lower concentrations of oxLDL.

Conclusion: This study presents the prevalence and concentration of oxLDL in postmenopausal women and demonstrates that oxLDL concentration can be quantified by proton NMR spectroscopy in large patient samples. The data suggest that oxLDL may be a biomarker for incipient atherosclerotic changes in postmenopausal women. In contrary to the association of dyslipoproteinemia and diabetes, higher blood urea concentrations were associated with lower concentrations of oxLDL.

aKlinik für Anästhesiologie mit Schwerpunkt orperative Intensiv medizin, Campus Virchow Klinikum und Campus CharitéMitte, Charité – Universitätsmedizin Berlin

bMedizinische Klinik IV, Campus Benjamin Franklin, Charité – Universitätsmedizin Berlin, Berlin, Germany

cKlinik für Plastiche Chirurgie und Dermatologie, Artemedic AG, Olten, Switzerland

dKlinik für Innere Medizin III, Alfred Krupp Krankenhaus Steele, Essen, Germany

eKlinisk Institut Nefrologi, Odense Univeristetshospital, Odense, Denmark

Correspondence to Professor Dr. rer. nat. Joachim Jankowski, Charité – Campus Benjamin Franklin, Medizinische Klinik IV, Hindenburgdamm 30, 12200 Berlin, Germany.Tel: +49 30 450 525 567; fax: +49 30 450 525 923; e-mail: Joachim.Jankowski@charite.de

Abbreviations: CVD, cardiovascular disease; HDL, high-density lipoprotein; 1H-NMR, proton nuclear magnetic resonance; IMT, intima–media thickness; LDL, low-density lipoprotein; oxLDL, oxidized low-density lipoprotein

Received 30 October, 2013

Revised 5 March, 2014

Accepted 5 March, 2014

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins