Journal of Hypertension

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Journal of Hypertension:
doi: 10.1097/HJH.0b013e328362feb7

CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

Kassan, Modara; Wecker, Andreaa; Kadowitz, Philipb; Trebak, Mohamedc; Matrougui, Khalida

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Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins


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