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Effects of acute and long-term slow breathing exercise on muscle sympathetic nerve activity in untreated male patients with hypertension

Hering, Dagmaraa; Kucharska, Wieslawaa; Kara, Tomasb,c; Somers, Virend K.c; Parati, Gianfrancod,e; Narkiewicz, Krzysztofa,c

doi: 10.1097/HJH.0b013e32835eb2cf
ORIGINAL PAPERS: Sympathetic activity

Objective: Acute slow breathing (SLOWB) affects sympathetic cardiovascular regulation, but its long-term effects are unknown. Using device-guided breathing we explored short-term and long-term SLOWB effects on blood pressure (BP), heart rate (HR) and muscle sympathetic nerve activity (MSNA) in essential hypertension.

Methods: We measured BP, HR and MSNA in 10 hypertensive individuals at rest, during laboratory stressors, before and after acute SLOWB, and 8 weeks after SLOWB exercise. Twelve matched hypertensive controls underwent a similar protocol excluding SLOWB intervention. Office and 24-h BP were obtained at baseline and at follow-up.

Results: Acute SLOWB had no influence on BP, HR, but decreased MSNA (P < 0.01). BP, HR, MSNA responses to handgrip were comparable before and after acute SLOWB. Acute SLOWB tended to reduce SBP (P = 0.09), HR (P = 0.08), but not MSNA (P = 0.20) responses to mental stress. Long-term SLOWB decreased office SBP (P < 0.001), DBP (P < 0.01), HR (P = 0.004), but not 24-h BP. Resting MSNA was unchanged after long-term SLOWB (P = 0.68). Long-term SLOWB did not influence BP, HR or MSNA responses to handgrip and cold pressor, but reduced SBP (P = 0.03), HR (P = 0.03) responses to mental stress without MSNA changes. In controls BP, HR, MSNA responses to laboratory stressors remained unchanged at baseline and at follow-up.

Conclusion: In essential hypertension, MSNA is reduced during acute SLOWB, but remains unaltered following long-term SLOWB. Long-term SLOWB reduces office, but not ambulatory BP and HR. SLOWB attenuates cardiovascular response to mental stress, but not physical stressors. These findings may be indicative of beneficial SLOWB effects on stress reduction in essential hypertension.

aDepartment of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland

bICRC, Department of Cardiovascular Diseases, St Anne's University Hospital Brno, Brno, Czech Republic

cDivision of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA

dDepartment of Clinical Medicine and Prevention, University of Milano-Bicocca

eDepartment of Cardiology, S. Luca Hospital, Istituto Auxologico Italiano, Milan, Italy

Correspondence to Dagmara Hering, MD, PhD, Department of Hypertension and Diabetology, Medical University of Gdansk, Debinki 7c, 80-952 Gdansk, Poland. Tel: +48 58 349 2065; fax: +48 58 349 2601; e-mail: hering@gumed.edu.pl

Abbreviations: BP, blood pressure; bpm, beat per minute; HR, heart rate; MSNA, muscle sympathetic nerve activity; SLOWB, slow breathing

Received 9 June, 2012

Revised 4 October, 2012

Accepted 8 January, 2013

© 2013 Lippincott Williams & Wilkins, Inc.