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Journal of Hypertension:
doi: 10.1097/HJH.0b013e32835bf798
ORIGINAL PAPERS: Sleep

Association between short total sleep time and hypertension: the Skara Sleep Cohort

Zou, Dinga; Eder, Derek N.a; Eskandari, Davouda; Grote, Ludgera; Boström, Kristina Bengtssonb; Lindblad, Ulfc; Hedner, Jana

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Abstract

Objectives: Apnea hypopnea index (AHI) is used to study the association between obstructive sleep apnea (OSA) and hypertension, but the independent contributions of total sleep time (TST) and apnea/hypopnea event count to hypertension have not been previously investigated. We studied the relationship between polysomnographically assessed TST and hypertension in a sex-balanced community-dwelling cohort of hypertensive patients and normotensive controls (Skara Sleep Cohort).

Methods: Participants (n = 344, men 173, age 61.2 ± 6.5 years, BMI 28.6 ± 4.8 kg/m2, mean ± SD) underwent ambulatory home polysomnography. Hypertension was defined according to contemporary Swedish national guidelines. A multivariate logistic regression model was used to predict hypertension status from TST and apnea/hypopnea count (total events/night) adjusting for sex, age and BMI.

Results: OSA was highly prevalent in this population (AHI 26 ± 24 events/h). Hypertensive patients had shorter TST than normotensive patients (353 ± 81 vs. 389 ± 65 min, P < 0.001), whereas total apnea/hypopnea count did not differ (167 ± 138 vs. 146 ± 148 events/night, P = 0.2). Multivariate logistic regression analysis revealed that short TST was associated with hypertension status [odds ratio 2.0; 95% confidence interval (95% CI) 1.2–3.3; P = 0.0015]. The significant association between apnea/hypopnea count and hypertension status was nonlinear (odds ratio 2.6; 95% CI 1.2–5.8; P = 0.04). The type of antihypertensive treatment was not found to significantly influence TST.

Conclusion: Short sleep time assessed by polysomnography was associated with hypertension in this community-dwelling population. Short sleep and presence of sleep apnea appear to independently link to hypertension.

© 2013 Lippincott Williams & Wilkins, Inc.

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