Skip Navigation LinksHome > January 2013 - Volume 31 - Issue 1 > Chronic consumption of a wild green oat extract (Neuravena)...
Journal of Hypertension:
doi: 10.1097/HJH.0b013e32835b04d4
ORIGINAL PAPERS: Therapeutic aspects

Chronic consumption of a wild green oat extract (Neuravena) improves brachial flow-mediated dilatation and cerebrovascular responsiveness in older adults

Wong, Rachel H.X.; Howe, Peter R.C.; Coates, Alison M.; Buckley, Jonathan D.; Berry, Narelle M.

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Abstract

Background: Heart health benefits have been attributed to regular consumption of oats. Preclinical evidence suggests that a wild green oat extract (WGOE) may improve vasodilator function, but this is yet to be evaluated in humans.

Objective: To determine whether regular daily consumption of WGOE can influence vasodilator function in systemic and cerebral arteries.

Methods: Thirty-seven healthy older adults (>60 years) completed a 24-week randomized, double-blind, placebo-controlled two-way crossover dietary intervention with 1500 mg/day of encapsulated WGOE or placebo. All assessments were conducted at the end of each 12-week intervention arm, after participants had fasted for at least 4 h and at least 18 h after they had taken their last dose of supplement. Flow-mediated dilatation (FMD) of the brachial artery and hypercapnia-induced increases of blood flow in the middle cerebral artery were used to measure systemic and cerebral vasodilator responsiveness (CVR), respectively.

Results: Compared with placebo, WGOE supplementation increased CVR and FMD to a similar extent (42 and 41%, respectively, P < 0.01 for both). The improvements in CVR and FMD were not correlated. Resting blood pressure did not alter with supplementation. Dose and treatment duration were well tolerated by participants.

Conclusion: WGOE supplementation can improve vasodilator function in systemic and cerebral arteries, suggesting a potential role in the maintenance of cardiovascular health.

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

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