Skip Navigation LinksHome > December 2012 - Volume 30 - Issue 12 > Gastrointestinal and renal excretion of potassium in African...
Journal of Hypertension:
doi: 10.1097/HJH.0b013e32835a27b3
ORIGINAL PAPERS: Kidney

Gastrointestinal and renal excretion of potassium in African–Americans and White Americans

Rosa, Robert M.a; De Jesus, Ernesta; Sperling, Kevina; Suh, Anniea; Gmurczyk, Aleksandraa; Myrie, Kevin A.a; Rosner, Karola; Lerma, Edgara; Yu, Williama; Breuer, Richardc; Young, James B.b

Collapse Box

Abstract

Objective: Several studies have confirmed the remarkable observation that cumulative urinary potassium (K+) excretion is less in African–Americans than White Americans even when identical amounts of potassium are provided in the diet. This study was designed to examine whether this decrease in urinary potassium could be compensatory to an increase in gastrointestinal excretion of potassium in African–Americans.

Methods: Twenty-three young, healthy, normotensive participants of both sexes and races were placed on a fixed diet of 100 mEq per day of K+ and 180 mEq per day of sodium (Na+) for 9 days. All urine and stool were collected daily and analyzed for electrolytes. Blood was obtained for determination of electrolytes, blood urea nitrogen (BUN), creatinine, glucose, insulin, renin, and aldosterone at the beginning and at the end of the study period.

Results: Cumulative urinary excretion of K+ was significantly less in African–Americans (609 ± 31 mEq) compared with White Americans (713 ± 22 mEq, P = 0.015). There was no significant racial difference, however, in the cumulative gastrointestinal excretion of K+ (105 ± 11 versus 95 ± 9 mEq, P = 0.28) in African–Americans versus White Americans, respectively.

Conclusion: The racial difference in urinary K+ handling manifested by decreased excretion of K+ in African–Americans cannot be attributed to an increase in net gastrointestinal excretion of this cation.

© 2012 Lippincott Williams & Wilkins, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.