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Heritability of central blood pressure and arterial stiffness: a twin study

Tarnoki, Adam Domonkosa,*; Tarnoki, David Laszloa,*; Stazi, Maria Antoniettab; Medda, Emanuelab; Cotichini, Rodolfob; Nisticò, Lorenzab; Fagnani, Corradob; Lucatelli, Pierleonec; Boatta, Emanuelec; Zini, Chiarac; Fanelli, Fabrizioc; Baracchini, Claudiod; Meneghetti, Giorgiod; Osztovits, Janose; Jermendy, Gyorgye; Préda, Istvánf,g; Kiss, Róbert Gáborf,g; Metneki, Juliah; Horvath, Tamasi; Karlinger, Kingaa; Racz, Adelj; Lannert, Agnesk; Molnar, Andrea Agnesf,g; Littvay, Leventel; Garami, Zsoltm; Berczi, Viktora; Schillaci, Giuseppen

Journal of Hypertension:
doi: 10.1097/HJH.0b013e32835527ae
ORIGINAL PAPERS: Genetic aspects
Abstract

Objective: Central blood pressure and aortic stiffness have been consistently reported as strong cardiovascular risk factors. Twin studies by comparing identical with nonidentical twins produce information on the relative contribution of genes and environment.

Methods: One hundred and fifty-four monozygotic (MZ) and 42 dizygotic (DZ) twin pairs (age 43 ± 17 years) from Hungary and the United States underwent brachial and central augmentation index (AIx), brachial and central pressure, and aortic pulse wave velocity (PWV) measurements with the invasively validated Arteriograph device. Bivariate Cholesky decomposition models were applied.

Results: Age-adjusted, sex-adjusted and country-adjusted heritability was 60.0% for central SBP [95% confidence interval (CI), 44.8–69.6%], 50.1% for aortic PWV (95%CI, 26.0–66.8%), 48.7% for aortic AIx (95%CI, 1.7–74.0%), 46.8% for brachial AIx (95%CI, 1.1–73.8%), 46.7% for central pulse pressure (PP) (95%CI, 12.4–61.4%), and 30.0% for brachial PP (95%CI, 0.0–53.4%). Central SBP and PP had strong bivariate correlations with brachial (r = 0.461 and 0.425) and central AIx (r = 0.457 and 0.419), as well as with aortic PWV (r = 0.341 and 0.292, all P < 0.001). Brachial PP had a weak correlation with brachial AIx (r = −0.118, P < 0.05), central AIx (r = −0.122, P < 0.05), and none with aortic PWV (r = 0.08, P = n.s.). Genetic factors explained a moderate phenotypic correlation between central PP, SBP, brachial SBP and aortic PWV.

Conclusions: Central systolic and PPs, brachial PP, AIx, aortic PWV are moderately heritable. A moderate genetic covariance among aortic PWV and central PP, central SBP and brachial SBP was found.

Author Information

aDepartment of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary

bGenetic Epidemiology Unit, National Centre of Epidemiology, Istituto Superiore di Sanità, Rome

cVascular and Interventional Radiology Unit, Department of Radiological Sciences, La Sapienza University of Rome, Rome

dDepartment of Neurosciences, School of Medicine, University of Padua, Padua, Italy

eBajcsy Zsilinszky Hospital, III. Department of Internal Medicine, Budapest

fResearch Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Budapest

gDepartment of Cardiology, Military Hospital – State Health Center, Budapest

hNational Centre for Healthcare Audit and Inspection, Budapest

iInstitute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest

jSemmelweis University, Faculty of Medicine, Budapest

kSemmelweis University, Faculty of Pharmacy, Budapest

lCentral European University, Budapest, Hungary

mThe Methodist Hospital DeBakey Heart and Vascular Center, Houston, Texas, USA

nUnit of Internal Medicine, University of Perugia at Terni, ‘S. Maria’ Hospital, Terni, Italy

*Adam Domonkos Tarnoki and David Laszlo Tarnoki contributed equally to the writing of this article.

Correspondence to Adam Domonkos Tarnoki, MD, Contact information: Department of Radiology and Oncotherapy, Semmelweis University, 78/a Ulloi street, Budapest, H-1082, Hungary. Tel: +36 30 6401183; fax: +36 1 2780368; e-mail: tarnoki2@gmail.com

Abbreviations: A, additive effect; AIx, augmentation index; BP, blood pressure; C, common environmental effect; CI, confidence interval; DZ, dizygotic; E, unique environmental effect; MZ, monozygotic; PP, pulse pressure; PWV, pulse wave velocity; rDZ, bivariate co-twin correlation in DZ; rMZ, bivariate co-twin correlation in MZ; SD, standard deviation

Received 22 December, 2011

Revised 17 March, 2012

Accepted 24 April, 2012

This article was presented during European Society of Hypertension's Annual conference in Milan, June 2011 (A.D.T., D.L.T., A.M.S., E.M., F.F., C.B., G.M., G.S., I.P., K.K., A.L., A.A.M., L.L., Z.G., V.B. Praise a fair day with twins: central blood pressure, pulse pressure and arterial stiffness. Journal of Hypertension, 29, e-Suppl A, June 2011, e469). The preliminary findings of arterial stiffness measurements based on fewer subjects were published in Journal for Vascular Ultrasound (Tarnoki AD et al. Twins lead to the prevention of atherosclerosis. Preliminary findings of International twin study 2009. Journal for Vascular Ultrasound 2011; 35(2):61–71.). A part of the results were presented at the European Society of Cardiology Annual Congress in Paris, August 2011 and at the Artery meeting in Paris, October 2011.

© 2012 Lippincott Williams & Wilkins, Inc.