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PROGRESSION TO HYPERTENSION IN THE CZECH POST-MONICA STUDY: 10-YEAR FOLLOW-UP: PP.7.297

Cifkova, R1; Skodova, Z1; Frohlich, J2; Lanska, V1; Bruthans, J1; Jozifova, M1; Adamkova, V1; Galovcova, M1; Wohlfahrt, P1; Krajcoviechova, A1

doi: 10.1097/01.hjh.0000378621.59601.09
Poster Session 07: Epidemiology of Hypertension and Metabolic Disorders 1

Objective: The Framingham study showed that high-normal BP (130–139/85–89 mmHg) is associated with an increased risk for cardiovascular disease and a higher rate of progression to hypertension. The aim of our study was to follow up a cohort of individuals with high-normal BP from a representative sample of the Czech population.

Design and Method : In 1997/8, a cross-sectional survey of CV risk factors was performed in 3,209 individuals from 9 districts of the Czech Republic (a 1% population sample aged 25–64 years, mean age 45.76±10.6 years; response rate 64.4%), a subgroup of 2,502 was re-examined 10 years later. At baseline, hypertension was found in 781 individuals who were excluded from this analysis.

Results : A stepwise increase in hypertension incidence occurred across the three normotensive BP categories; in males, 17.7% of participants with optimal BP, 35.9% with normal, and 63.0% with high-normal BP progressed to hypertension over 10 years; the respective figures in females were 15.5%, 41.6%, and 71.9%.

Conclusions: A high-normal BP at baseline was associated with a substantially increased risk of developing hypertension over a period of 10 years compared with optimal and normal BP. Age, obesity, and weight gain contributed independently to progression to hypertension.

1Inst. Clin. Exp. Medicine, Prague, Czech Republic

2Univ. British Columbia, Vancouver, Canada

© 2010 Lippincott Williams & Wilkins, Inc.