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The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome

Nilsson, Peter Ma; Lurbe, Emparb; Laurent, Stéphanec

Journal of Hypertension:
doi: 10.1097/HJH.0b013e3282f82c3e
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Abstract

Early vascular ageing is common in patients with hypertension and increased burden of cardiovascular risk factors, often influenced by chronic inflammation. One aspect of this vascular ageing is arterial stiffening, as measured by increased pulse wave velocity or augmentation index and central pressure. Several studies have indicated that this process starts early in life and that arterial function and ageing properties could be programmed during foetal life or influenced by adverse growth patterns in early postnatal life. This could explain the repeated findings in observational epidemiology that an inverse association exists between birth weight, adjusted for gestational age, and systolic blood pressure elevation in childhood, adolescence and adulthood, as well as for increased cardiovascular risk. One new marker of increased pulse pressure and arterial ageing is telomere length, as regulated by telomerase enzymatic activity. Future studies will hopefully shed light on the possibilities to halt or even reverse vascular ageing, and thereby also influence telomere biology and its different expressions.

Author Information

aDepartment of Clinical Sciences, University Hospital, Lund University, Malmo, Sweden

bCardiovascular Risk Unit, Consorcio Hospital General Universitario, University of Valencia, Valencia, Spain

cUniversité Paris-Descartes, Faculté de Médecine, Department of Pharmacology, Georges Pompidou European Hospital, and INSERM U652, Paris, France

Received 10 November, 2007

Revised 6 January, 2008

Accepted 14 January, 2008

Correspondence to Peter M. Nilsson MD, PhD, Department of Clinical Sciences Medicine, Lund University, University Hospital, S-205 02 Malmo, Sweden Tel: +46 40 33 24 15; fax: +46 40 92 32 72; e-mail: Peter.Nilsson@med.lu.se

© 2008 Lippincott Williams & Wilkins, Inc.