Aim: The present research has been undertaken prospectively to study the impact of birthweight and growth pattern on blood pressure changes from birth through the first year of life.
Methods: Parents of newborns born at term (gestational age > 37 weeks) after uncomplicated pregnancies and in the absence of perinatal illness were randomly invited to allow their children to participate in the study. One hundred and forty-nine (84 male and 65 female) newborns were included in the present analysis. The newborns were divided into four groups according to birthweight: < 2500 g (n = 23); 2500–2999 g (n = 39); 3000–3500 g (n = 48); and > 3500 g (n = 39).
Results: At birth systolic and diastolic blood pressure were significantly lower and heart rate was significantly higher in those children with the lowest birthweight as compared to those in the other groups. During the first month of life a significant trend, inversely related to birthweight, was present for systolic as well as diastolic blood pressure. After the first month of life, at 3, 6, 9 and at 12 months, systolic and diastolic blood pressure were similar across birthweight groups. In a multiple regression analysis, birthweight was a positive independent determinant of systolic blood pressure at birth and an inverse independent determinant of the increment of systolic blood pressure during the first month of life and of the systolic blood pressure at the end of the first year.
Conclusions: In summary, the present study goes further towards understanding blood pressure changes in low birthweight babies. Beginning at birth, both blood pressure values, as well as changes in blood pressure, provide information about the impact of intrauterine life on the risk of developing hypertension later in life.
aPediatric Nephrology and Cardiovascular Risk Unit, Consorcio Hospital General, Spain
bHypertension Clinic, Hospital Clinico, University of Valencia, Spain
Received 12 April, 2006
Revised 4 July, 2006
Accepted 29 August, 2006
Correspondence and requests for reprints to Empar Lurbe, MD, Cardiovascular Risk Unit, Department of Pediatrics, Consorcio Hospital General, University of Valencia, Avda Tres Cruces s/n, 46014 Valencia, Spain fax: +34 96 3862647; e-mail: email@example.com
Sponsorship: The Instituto de Salud Carlos III, Ministry of Health, Madrid, Spain (RECAVA C03/01) funded the study in Spain.
Conflict of interest: none.
Part of this study was presented as an abstract to the 19th Annual Scientific Meeting of the American Society of Hypertension, New York, 2004.