Journal of Hypertension

Skip Navigation LinksHome > March 2005 - Volume 23 - Issue 3 > Is plasma cardiotrophin-1 a marker of hypertensive heart dis...
Journal of Hypertension:
Original papers: Heart

Is plasma cardiotrophin-1 a marker of hypertensive heart disease?

López, Begoñaa,*; González, Arantxaa,*; Lasarte, Juan Jb; Sarobe, Pablob; Borrás, Franciscob; Díaz, Agnesc; Barba, Joaquínc; Tomás, Lourdesd; Lozano, Elisad; Serrano, Manueld,e; Varo, Nereaa,f; Beloqui, Oscarg; Fortuño, María Aa; Díez, Javiera,c

Collapse Box


Objective: This study was designed to investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, is related to hypertensive heart disease, as defined by the presence of echocardiographically assessed left ventricular hypertrophy (LVH).

Methods: The study was performed in 31 normotensive subjects and 111 patients with never-treated essential hypertension (54 without LVH and 57 with LVH). Causes of LVH other than hypertension were excluded after a complete medical workup. A novel enzyme-linked immunosorbent assay was developed to measure plasma CT-1.

Results: Plasma CT-1 was increased (P < 0.001) in hypertensives compared with normotensives. The value of CT-1 was higher (P < 0.001) in hypertensives with LVH than in hypertensives without LVH. Some 31% of patients without LVH exhibited values of CT-1 above the upper normal limit in normotensives. A direct correlation was found between CT-1 and left ventricular mass index (r = 0.319, P < 0.001) in all subjects. Receiver operating characteristic curves showed that a cutoff of 39 fmol/ml for CT-1 provided 75% specificity and 70% sensitivity for predicting LVH with a relative risk of 6.21 (95% confidence interval, 2.95 to 13.09).

Conclusions: These results show an association between LVH and the plasma concentration of CT-1 in essential hypertension. Although preliminary, these findings suggest that the determination of CT-1 may be an easy and reliable method for the initial screening and diagnosis of hypertensive heart disease.

© 2005 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.