Journal of Hypertension

Skip Navigation LinksHome > March 2005 - Volume 23 - Issue 3 > Is plasma cardiotrophin-1 a marker of hypertensive heart dis...
Journal of Hypertension:
Original papers: Heart

Is plasma cardiotrophin-1 a marker of hypertensive heart disease?

López, Begoñaa,*; González, Arantxaa,*; Lasarte, Juan Jb; Sarobe, Pablob; Borrás, Franciscob; Díaz, Agnesc; Barba, Joaquínc; Tomás, Lourdesd; Lozano, Elisad; Serrano, Manueld,e; Varo, Nereaa,f; Beloqui, Oscarg; Fortuño, María Aa; Díez, Javiera,c

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Abstract

Objective: This study was designed to investigate whether plasma concentration of cardiotrophin-1 (CT-1), a cytokine that induces cardiomyocyte hypertrophy and stimulates cardiac fibroblasts, is related to hypertensive heart disease, as defined by the presence of echocardiographically assessed left ventricular hypertrophy (LVH).

Methods: The study was performed in 31 normotensive subjects and 111 patients with never-treated essential hypertension (54 without LVH and 57 with LVH). Causes of LVH other than hypertension were excluded after a complete medical workup. A novel enzyme-linked immunosorbent assay was developed to measure plasma CT-1.

Results: Plasma CT-1 was increased (P < 0.001) in hypertensives compared with normotensives. The value of CT-1 was higher (P < 0.001) in hypertensives with LVH than in hypertensives without LVH. Some 31% of patients without LVH exhibited values of CT-1 above the upper normal limit in normotensives. A direct correlation was found between CT-1 and left ventricular mass index (r = 0.319, P < 0.001) in all subjects. Receiver operating characteristic curves showed that a cutoff of 39 fmol/ml for CT-1 provided 75% specificity and 70% sensitivity for predicting LVH with a relative risk of 6.21 (95% confidence interval, 2.95 to 13.09).

Conclusions: These results show an association between LVH and the plasma concentration of CT-1 in essential hypertension. Although preliminary, these findings suggest that the determination of CT-1 may be an easy and reliable method for the initial screening and diagnosis of hypertensive heart disease.

© 2005 Lippincott Williams & Wilkins, Inc.

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