Journal of Hypertension

Skip Navigation LinksHome > July 2002 - Volume 20 - Issue 7 > Structural changes in small resistance arteries and left ven...
Journal of Hypertension:
Original papers: Heart

Structural changes in small resistance arteries and left ventricular geometry in patients with primary and secondary hypertension

Muiesan, Maria Lorenzaa; Rizzoni, Damianoa; Salvetti, Massimoa; Porteri, Enzoa; Monteduro, Cristinaa; Guelfi, Danielea; Castellano, Maurizioa; Garavelli, Guidob; Agabiti-Rosei, Enricoa

Collapse Box


Objective : To prospectively evaluate the interrelationships between left ventricular (LV) geometry and structural characteristics of the vessel wall in small resistance arteries in patients with consecutive primary and secondary hypertension.

Methods : In 14 patients with phaeochromocytoma, 12 with primary aldosteronism, 25 with renovascular, 25 with essential hypertension and 12 normotensive controls, an echocardiographic study for the measurement of LV mass index and relative wall thickness (RWT) was performed. Morphological characteristics of small resistance arteries (relaxed diameter < 300 μm) were directly evaluated by a micromyographic technique.

Results : A total of 25 patients had normal LV mass and geometry, 28 patients had normal RWT (< 0.45) and 23 patients had a RWT 0.45; all normotensive subjects had normal LV mass and geometry. Media to lumen ratio (M/L) in subcutaneous small arteries was greater in hypertensive patients with concentric LV hypertrophy in respect to normotensives (ANOVA P = 0.01) and hypertensives with normal LV geometry (ANOVA P = 0.05). In the whole group of hypertensive patients the correlation coefficient between M/L and LV mass index was 0.33 (P < 0.05); the correlation coefficient between M/L and RWT was 0.46 (P < 0.01) and it was higher in primary aldosteronism (r = 0.67) and renovascular hypertension patients (r = 0.46).

Conclusions : A close relation between morphology of subcutaneous small resistance arteries and LV geometric patterns may be observed in hypertensive patients; this relationship is more evident when the renin–angiotensin–aldosterone system is activated.

© 2002 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.