Journal of Hypertension

Skip Navigation LinksHome > August 1987 - Volume 5 - Issue 4 > Effect of [alpha]1-Adrenoceptor Blockade on Blood Pressure a...
Journal of Hypertension:
Article: PDF Only

Effect of [alpha]1-Adrenoceptor Blockade on Blood Pressure and Iliac Vascular Resistance in Normotensive and Goldblatt Hypertensive Dogs; Influence of Dietary Salt and DOCA-Salt.

Zeigler, David W.; Zimmerman, Ben G.

Collapse Box


Instrumented normotensive and two-kidney, one clip Goldblatt hypertensive dogs were placed on normal salt, high salt and DOCA-salt regimens and the effect on mean arterial blood pressure (MAP) and iliac vascular resistance (IVR) determined. High salt and DOCA-salt did not alter these variables in the Goldblatt hypertensive group. DOCA-salt increased MAP in the normotensives by 12 mmHg; however, IVR was not significantly increased by this treatment. In order to determine the degree of sympathetic tone in the iliac vascular bed, the change in IVR evoked by the [alpha]1-adrenoceptor antagonists, urapidil and prazosin, was assessed. There were similar reductions in MAP and IVR after [alpha]1-blockade in both groups of dogs, regardless of the salt regimen. However, urapidil caused a greater decrease in MAP in the normotensives than in the hypertensives. Captopril administration after [alpha]1-blockade caused further reductions in MAP and IVR in the hypertensives, and in the MAP of the normotensive dogs on normal or high salt, indicating that the renin-angiotensin system maintained blood pressure in these groups. These results suggest that sympathetic tone is not increased by high salt- or DOCA-salt in normotensive or Goldblatt hypertensive dogs for the 8-11 day duration of these treatments.

(C) Lippincott-Raven Publishers.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.