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Biologic Agents for Moderate-to-Severe Plaque Psoriasis: Mechanisms of Action and Treatment Considerations

Cantrell, Wendy; Kaler, Rhonda

Journal of the Dermatology Nurses' Association: July/August 2014 - Volume 6 - Issue 4 - p 178–196
doi: 10.1097/JDN.0000000000000055
Feature Articles

ABSTRACT: Psoriasis is a chronic, inflammatory, immune-mediated skin disease that affects roughly 2% of adults in the United States. The immunopathogenic pathways associated with psoriasis are complex, and to effectively target the underlying cytokine networks involved in disease progression, drugs are needed that act on specific components of the immune system. As understanding of the role of proinflammatory signaling molecules in the psoriatic disease process has evolved, several biologic agents have been engineered to block key cytokines associated with psoriasis. Recently, improvements in the understanding of the pathogenesis have led to the development of agents that may target the mechanism of disease more directly. This review describes the immunopathogenesis of psoriasis and how targeting disease-specific mechanisms with biologic agents may improve clinical outcomes and potentially result in better safety profiles than conventional agents. Results from pivotal clinical studies evaluating the efficacy and safety of approved tumor necrosis factor-α antagonists (etanercept, infliximab, and adalimumab) and the interleukin-12/23 inhibitor ustekinumab are summarized. In addition, we include clinical findings to date evaluating a new class of biologics that neutralize interleukin-17A (secukinumab, ixekizumab) or act as an interleukin-17 receptor antagonist (brodalumab). Finally, this review discusses efficacy and safety factors, as well as patient characteristics to consider, when selecting a biologic agent for psoriasis disease management.

Wendy Cantrell, DNP, CRNP, UAB Dermatology, Birmingham, AL.

Rhonda Kaler, RN, BSN, UAB Dermatology, Birmingham, AL.

Wendy Cantrell and Rhonda Kaler participated in an advisory board and received honorarium from Novartis. The authors have participated as study staff for Novartis. Research funding is directed to UAB Dermatology and not the authors directly.

The authors received no financial support or other form of compensation related to the development of this manuscript. Technical assistance with copyediting and final styling of the manuscript was provided by Oxford PharmaGenesis, Inc., and this assistance was supported by Novartis Pharmaceutical Corporation.

The authors declare no conflicts of interest.

Correspondence concerning this article should be addressed to Wendy Cantrell, DNP, CRNP, UAB Dermatology, 2000 6th Avenue South, 3rd Floor, Birmingham, AL 35233. E-mail: wcantrell@uabmc.edu

Copyright © 2014 by the Dermatology Nurses' Association.