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The Bioresorption and Guided Bone Regeneration of Absorbable Hydroxyapatite-Coated Magnesium Mesh

Byun, Soo-Hwan DDS, MS; Lim, Ho-Kyung DDS, MSD; Kim, Soung-Min DDS, PhD; Lee, Sung-Mi PhD; Kim, Hyoun-Ee PhD; Lee, Jong-Ho DDS, PhD

Journal of Craniofacial Surgery: March 2017 - Volume 28 - Issue 2 - p 518–523
doi: 10.1097/SCS.0000000000003383
Anatomical Studies

Introduction: Nonabsorbable metallic membrane for guided bone regeneration is remained permanently even though after complete healing. There would be metallic exposure followed by the risk of infection; the membrane should be removed for the additional procedure such as implant installation. Since absorbable nonmetallic mesh is absorbed within 3 to 6 months, it is unnecessary to be removed. However, the absorbable membrane shows lower retention, lower mechanical strength, and difficulty of manipulation than the nonabsorbable ones.

The purpose of this study is to evaluate the ability of absorbable metallic mesh (hydroxyapatite-coated magnesium mesh) with acceptable mechanical properties and satisfying biocompatibility.

Methods: The bioresorption and fate of magnesium were evaluated in Sprague Dawley rat (SD rat) with critical defect of calvarium. The critical defect with a diameter of 8 mm was made on calvarium using trephine bur in 18 SD rats. The defected models were divided into 2 groups: the control group (9 SD rat) without mesh and the experimental group (9 SD rat) with the insertion of prototype HA-coated magnesium mesh. The 3 SD rats were sacrificed at 6, 12, and 18 weeks. The histopathological and radiographic examinations were performed afterward.

Results: In the control group, there was no specific symptom. The experimental group also showed no specific symptom including swelling and dehiscence related to hydrogen gas formation. From 6 to 18 weeks, the experimental group showed the progressive absorption and fracture of magnesium mesh. However, there was no specific effectiveness of guided bone regeneration in both groups. There was no significant difference in bone volume, bone surface, and bone volume fraction between the negative control group and the group with magnesium mesh (P >0.05).

Conclusion: Hydroxyapatite-coated magnesium mesh showed reasonable process of bioresorption and bony reaction; however, the effectiveness of guided bone regeneration and management of the bioresorption rate should be reconsidered.

*Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul

Department of Oral and Maxillofacial Surgery, Dongtan Sacred Heart Hospital, Hallym University Medical Center, Kyonggi-do

Department of Oral and Maxillofacial Surgery, Korea University Medical Center, Guro Hospital

§Oral Cancer Center and Clinical Trial Center, Seoul National University Dental Hospital

||Department of Materials Science and Engineering, Seoul National University

Biomedical Implant Convergence Research Lab, Advanced Institutes of Convergence Technology

#Dental Research Institute, Seoul National University, Seoul, Korea.

Address correspondence and reprint requests to Jong-Ho Lee, DDS, MSD, PhD, Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, 275-1 Yeongeon-dong, Jongno-gu, Seoul #110-749, Korea; E-mail: leejongh@snu.ac.kr

Received 23 June, 2016

Accepted 13 October, 2016

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI15C1535).

This research was supported by Hallym University Research Fund 2016 (HURF-2016-25).

The authors report no conflicts of interest.

© 2017 by Mutaz B. Habal, MD.