Bisphosphonates are widely used for treatment or prevention of bone diseases characterized by high osteoclastic activity. Among the oral medicines used to treat osteoporosis, alendronate has been often used. Despite of the low rate of complications on its use, cases of osteonecrosis of the jaw have been reported on literature after tooth extractions. The main symptoms include pain, tooth mobility, swelling, erythema, and ulceration. The risk factors related to osteonecrosis of the jaw associated with bisphosphonate are exposition time to the medicine, routes of administration, and oral surgical procedures performed. The aim of this work is to report a case of a patient showing osteonecrosis of the jaw associated with the use of oral bisphosphonates after tooth extractions. The patient was treated through the suspension of the alendronate with the removal of the necrotic tissue and the foci of infection. After a year's follow-up, the patient showed no recurrence signs. From the foregoing, the interruption of the alendronate use and the surgical treatment associated to antibiotic therapy showed effective on the patient's treatment.
*Oral and Maxillofacial Surgery of Batista Memorial Hospital
†Oral and Maxillofacial Surgery of Doctor José Frota Institute
‡Oral and Maxillofacial Surgery of Doctor José Frota Institute
§Stomatology and Oral and Maxillofacial Surgery of Federal University of Ceará dental school—UFC, Fortaleza, Ceará, Brazil.
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Received 11 May, 2015
Accepted 28 June, 2015
The authors report no conflicts of interest.