Journal of Craniofacial Surgery

Skip Navigation LinksHome > November 2013 - Volume 24 - Issue 6 > Silk Fibroin and 4-Hexylresorcinol Incorporation Membrane fo...
Journal of Craniofacial Surgery:
doi: 10.1097/SCS.0b013e3182a3050c
Original Articles

Silk Fibroin and 4-Hexylresorcinol Incorporation Membrane for Guided Bone Regeneration

Lee, Sang-Woon DDS*; Kim, Seong-Gon DDS, PhD*; Song, Ji-Young DDS; Kweon, HaeYong PhD; Jo, You-Young PhD; Lee, Kwang-Gill PhD; Kang, Seok-Woo PhD; Yang, Byoung-Eun DDS, PhD§

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Abstract: The objective of this study was to demonstrate that a silk fibroin (SF) and 4-hexylresorcinol (4-HR) incorporation membrane could be used for a guided bone regeneration technique. Fourier transform infrared measurements were obtained to determine change of physical property of SF membrane by 4-HR incorporation. Two peri-implant defects, 3.0 × 5.0 mm (width × length), were prepared on the lateral side of the implant hole in the tibia of New Zealand white rabbits (n = 8). The peri-implant defect was left unfilled in the control group. Silk fibroin + 4-HR membrane was applied to the peri-implant defect in the experimental group. The 8 animals were killed at 8 weeks after implantation. Subsequently, removal torque test and histomorphometric evaluation were done. Fourier transform infrared spectroscopy showed no specific chemical interaction between 4-HR and SF. In the histomorphometric analysis, the mean bone regeneration was 18.3 ± 1.9 mm2 in the experimental group and 9.3 ± 0.9 mm2 in the control group (P = 0.004). In conclusion, the SF and 4-HR incorporation membrane successfully regenerated bone in the rabbit tibia peri-implant bone defect model.

© 2013 by Mutaz B. Habal, MD.

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