Journal of Craniofacial Surgery

Skip Navigation LinksHome > May 2013 - Volume 24 - Issue 3 > Radiographic Evaluation of Regenerated Bone Following Poly(L...
Journal of Craniofacial Surgery:
doi: 10.1097/SCS.0b013e31827ca01a
Original Articles

Radiographic Evaluation of Regenerated Bone Following Poly(Lactic-Co-Glycolic) Acid/Hydroxyapatite and Deproteinized Bovine Bone Graft in Sinus Lifting

y Baena, Ruggero Rodriguez MD, DDS*; Lupi, Saturnino Marco DDS*; Pastorino, Roberta MEng, PhD; Maiorana, Carlo MD, DDS; Lucchese, Alessandra DDS, MSOrth§; Rizzo, Silvana MD, DDS*

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Abstract: Although numerous biomaterials are used for maxillary sinus-lift surgery, the ideal material for such procedures has not yet been identified. Both heterologous and alloplastic bone substitutes have a solely osteoconductive effect and lack the osteoinductive properties of the bone morphogenetic proteins typical of autologous bone. Our group assessed a new alloplastic graft material, poly(lactic-co-glycolic) acid/hydroxyapatite (PLGA/HA), implanted in a human model of maxillary sinus-lift surgery. For this prospective, random, double-blind trial, we used deproteinized bovine bone (DBB) as the comparison material. Radiographic bone vertical height and density were assessed at approximately 28 weeks after grafting using cone-beam computed tomography. The vertical dimension of the regenerated bone was equivalent between the 2 groups. The density of the bone regenerated using PLGA/HA was significantly lower than that obtained with DBB. Despite clinical assessments demonstrating that PLGA/HA has sufficient characteristics for use in sinus-lift surgery, DBB provided greater bone density and an equivalent vertical dimension of grafted bone. Further studies are needed to supplement the radiologic findings with histologic and micromorphometric examinations.

© 2013Wolters Kluwer Health | Lippincott Williams & Wilkins

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