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Journal of Craniofacial Surgery:
doi: 10.1097/SCS.0b013e318240fed7
Original Articles

Coordinated Events: FGF Signaling and Other Related Pathways in Palatogenesis

Snyder-Warwick, Alison K. MD*†; Perlyn, Chad A. MD, PhD

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Abstract

Abstract: Cleft palate is a common craniofacial anomaly that is costly to both patients and the health care system. Investigation of each stage of palate development enhances understanding of this anomaly. Although the exact molecular signaling mechanisms that contribute to palatogenesis remain elusive, multiple pathways, such as fibroblast growth factor (FGF) signaling, have been recognized as important contributors. Alterations in FGF signaling have previously been implicated in palatal clefting. The current review discusses FGF signaling and the major signaling mediators affecting FGF signaling during each stage of palatogenesis.

© 2012 Mutaz B. Habal, MD

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