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Coordinated Events: FGF Signaling and Other Related Pathways in Palatogenesis

Snyder-Warwick, Alison K. MD*†; Perlyn, Chad A. MD, PhD

Journal of Craniofacial Surgery:
doi: 10.1097/SCS.0b013e318240fed7
Original Articles

Abstract: Cleft palate is a common craniofacial anomaly that is costly to both patients and the health care system. Investigation of each stage of palate development enhances understanding of this anomaly. Although the exact molecular signaling mechanisms that contribute to palatogenesis remain elusive, multiple pathways, such as fibroblast growth factor (FGF) signaling, have been recognized as important contributors. Alterations in FGF signaling have previously been implicated in palatal clefting. The current review discusses FGF signaling and the major signaling mediators affecting FGF signaling during each stage of palatogenesis.

Author Information

From the *Division of Plastic Surgery and †Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri; and ‡Florida International University College of Medicine, Miami Children’s Hospital; Division of Plastic Surgery, Miami, Florida.

Received April 15, 2011.

Accepted for publication July 11, 2011.

Address correspondence and reprint requests to Dr. Chad A. Perlyn, Florida International University College of Medicine, Division of Plastic Surgery, Miami Children’s Hospital, 3100 SW 62nd Ave, Miami, FL 33155; E-mail:

The authors report no conflicts of interest.

© 2012 Mutaz B. Habal, MD