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Implant Therapy in Irradiated Patients

Sammartino, Gilberto MD, DDS*; Marenzi, Gaetano PhD, DDS*; Cioffi, Iacopo DS*; Teté, Stefano MD, DDS†; Mortellaro, Carmen MD, DDS‡

Journal of Craniofacial Surgery:
doi: 10.1097/SCS.0b013e318207b59b
Original Articles

In this multicenter study, submerged implants were prospectively followed to evaluate their long-term prognosis in irradiated patients. In a total of 77 patients treated for oral or neck cancer, 188 implants were consecutively placed. After a healing period, the successfully integrated implants were restored with 69 removable and 38 fixed restorations. The implants cumulative survival and success rates were evaluated over a period of at least 36 months. In addition, cumulative success rates were calculated for implant subgroups divided per implant site (mandible or maxilla), radiation dosage, and the time interval between the last irradiation and implant placement. During the healing period, 20 implants did not successfully integrate, whereas 168 implants were classified as success (including both survival and success rates). The analysis of implant subgroups showed slightly more favorable cumulative success rate for mandibular implants (98.4%) compared with maxillary implants (57.1%) and clearly better success rate for a radiation dosage minor of 50-Gy doses. A time greater than 12 months as interval between last irradiation and implant placement seems not to promote better clinical results.

Author Information

From the *Department of Odontostomatologic and Maxillo-Facial Sciences, University of Naples "Federico II" Faculty of Medicine, Naples; †Department of Odontostomatologic Science, University of Chieti. Faculty of Medicine, Chieti; and ‡Department of Medical Science, University of Eastem Piedimont "Amedeo Avogadro" Novara Faculty of Medicine, Novara, Italy.

Received July 2, 2010.

Accepted for publication August 1, 2010.

Address correspondence and reprint requests to Carmen Mortellaro, MD, Via Sacchi 4, Torino, Italy; E-mail:

The authors report no conflicts of interest.

© 2011 Mutaz B. Habal, MD