Skip Navigation LinksHome > February 2007 - Volume 13 - Issue 1 > Familial Mediterranean Fever Successfully Treated With Etane...
JCR: Journal of Clinical Rheumatology:
doi: 10.1097/01.rhu.0000255772.25658.7c
Case Report

Familial Mediterranean Fever Successfully Treated With Etanercept

Mor, Adam MD*; Pillinger, Michael H. MD*; Kishimoto, Mitsumasa MD*; Abeles, Aryeh M. MD*; Livneh, Avi MD†‡

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Abstract

Colchicine is the only drug known to effectively prevent familial Mediterranean fever (FMF) attacks, as well as FMF-associated amyloidosis. Unfortunately, colchicine is neither always effective nor always well tolerated, leaving some patients and their physicians with inadequate weaponry to fight this hazardous disease. We present a patient with recurrent episodes of abdominal, scrotal, and joint attacks, who was diagnosed with FMF and advised to take colchicine. Diarrhea prevented optimal treatment with this drug and led to a trial of etanercept, with resolution of FMF manifestations. This case adds to a growing body of evidence suggesting that tumor necrosis factor (TNF) blockade may result in resolution and prevention of further FMF attacks.

© 2007 Lippincott Williams & Wilkins, Inc.

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