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New Onset Systemic Lupus Erythematosus in a Transgender Man: Possible Role of Feminizing Sex Hormones

Santos-Ocampo, Alberto S. MD

JCR: Journal of Clinical Rheumatology:
doi: 10.1097/
Case Reports

Systemic lupus erythematosus (SLE) is rare in men, and significantly more common in women. Sex hormone influences are believed to a play a role in these gender differences. We present the unusual case of a transgender man who had been taking feminizing sex hormones, who later developed new onset SLE with cardiorespiratory and renal involvement. While not definitive, this case raises intriguing possibilities on the relationship between the use of feminizing sex hormones and the development of SLE.

In Brief

Could feminizing hormone have played a role in potentiating the development of SLE in this transgender man from American Samoa?

Author Information

From the Section of Rheumatology, Straub Clinic and Hospital, Honolulu, Hawaii.

No grants or funding was required in the preparation of this manuscript. Dr. Santos-Ocampo is on the speaker's bureau of Pfizer, Inc.

Reprints: Alberto S. Santos-Ocampo, Section of Rheumatology, Tube #3, Straub Clinic and Hospital, 888 South King Street, Honolulu, Hawaii 96813. E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.