Skip Navigation LinksHome > August 2014 - Volume 20 - Issue 5 > Collagenous Colitis in Systemic Sclerosis: An Overlooked and...
JCR: Journal of Clinical Rheumatology:
doi: 10.1097/RHU.0000000000000121
Case Reports

Collagenous Colitis in Systemic Sclerosis: An Overlooked and Treatable Complication

Abignano, Giuseppina MD, PhD*†; Scott, Nigel MD; Wollheim, Frank A. MD, PhD, FRCP§; Emery, Paul MD, MA, FRCP*†; Buch, Maya H. PhD, MBChB, FRCP*†; Del Galdo, Francesco MD, PhD*†

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Abstract

Abstract: Collagenous colitis (CC) is an inflammatory bowel condition of unknown etiology. Systemic sclerosis (SSc) has been associated with CC in a few cases, but it is not clear whether CC could be considered an unusual manifestation of SSc or an independent condition. Here we present a case of SSc-associated CC and compare routine histology and immunofluorescence studies for allograft inflammatory factor 1 and caveolin 1 expression with other cases of CC and healthy controls. All CC biopsies showed characteristic sublaminal collagen accumulation and a decrease of caveolin 1 expression, this latter finding consistent with and common in any fibrotic reaction. In contrast, the expression of allograft inflammatory factor 1 was increased only in the SSc-CC specimen, suggesting a distinct pathogenesis. A literature review revealed 6 previously reported cases of SSc-CC with common clinical features. These observations suggest that CC should be suspected as a rare gastrointestinal complication of SSc and that clinicians should be aware of the possibility in SSc patients developing watery diarrhea.

© 2014 by Lippincott Williams & Wilkins, Inc.

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