Skip Navigation LinksHome > September 2012 - Volume 18 - Issue 6 > Relation of Sensory Peripheral Neuropathy in Sjögren Syndrom...
JCR: Journal of Clinical Rheumatology:
doi: 10.1097/RHU.0b013e3182675e4f
Original Articles

Relation of Sensory Peripheral Neuropathy in Sjögren Syndrome to Anti-Ro/SSA

Scofield, Amanda Kyle*; Radfar, Lida DDS; Ice, John A. MD*; Vista, Evan MD; Anaya, Juan-Manuel MD; Houston, Glen DDS; Lewis, David DDS; Stone, Donald U. MD¶#; Chodosh, James MD††; Hefner, Kimberly MD*; Lessard, Christopher J. PhD*; Moser, Kathy L. PhD*‡; Scofield, Robert Hal MD*†**

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Background: Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease.

Methods: Eight-eight patients attending a dry eyes–dry mouth clinic were diagnosed to have primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay.

Results: Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception, or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ2 = 8.46, P = 0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) had neuropathy (χ2 = 5.587, P = 0.018, compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome.

Conclusions: Sensory peripheral neuropathy is common among patients with Sjögren syndrome and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion.

© 2012 Lippincott Williams & Wilkins, Inc.

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