Skip Navigation LinksHome > June 2010 - Volume 16 - Issue 4 > Fatal Allopurinol-Induced Hypersensitivity Syndrome Associat...
JCR: Journal of Clinical Rheumatology:
doi: 10.1097/RHU.0b013e3181dfbaf7
Case Report

Fatal Allopurinol-Induced Hypersensitivity Syndrome Associated With Pancreatic Abnormalities

Fathallah, Neila MD*; Ben Salem, Chaker MD*; Slim, Raoudha MD*; Kaabia, Naoufel MD†; Letaief, Amel MD†; Bouraoui, Kamel MD*

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Allopurinol hypersensitivity syndrome is a severe adverse reaction characterized by rash, fever, and internal organ involvement. We report a case of fatal allopurinol-induced hypersensitivity syndrome associated with acute pancreatitis.

A 46-year-old man was treated by allopurinol for asymptomatic hyperuricemia. The patient developed a diffuse erythrodermic maculopapular eruption and fever. Laboratory analysis revealed cytolysis and cholestasis, amylases and lipases were highly elevated. Computed tomography scans revealed pancreatitis Grade C. The treatment of asymptomatic hyperuricemia should only be initiated when there is a clear indication to reduce the incidence and the severe consequences of allopurinol hypersensitivity syndrome.

© 2010 Lippincott Williams & Wilkins, Inc.

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