Skip Navigation LinksHome > February 2005 - Volume 11 - Issue 1 > Drug-Induced Lupus After Treatment With Infliximab in Rheuma...
JCR: Journal of Clinical Rheumatology:
Case Report

Drug-Induced Lupus After Treatment With Infliximab in Rheumatoid Arthritis

Benucci, Maurizio MD*; Gobbi, Francesca Li MD*; Fossi, Fiammetta MD*; Manfredi, Mariangela BD†; Del Rosso, Angela MD‡

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Abstract

We report a case of a 45-year-old man with an 8-month history of rheumatoid arthritis, who was treated with hydroxychloroquine 400 mg per day and 15 mg intramuscular methotrexate per week without reaching a good control of the disease. The patient was successfully treated with 3 mg/kg infliximab for 20 weeks. Before the last infusion, drug-induced lupus (DIL) was diagnosed based on the clinical features of fever > 37.5°C, recurrence of active synovitis, myalgia, erythematosus rash, pericardial and pleural effusion, and of some laboratory findings (antinuclear antibodies 1:160 and anti double-strand DNA positive by DNA recombinant plasmid assay dsDNA). After infliximab discontinuation and the beginning of therapy with methylprednisolone, lupus symptoms resolved within 6 weeks. A new rheumatoid arthritis flare, occurring after 8 weeks, was controlled by methotrexate plus leflunomide. We also review the development of antinuclear and antidouble-strand DNA antibodies and drug-induced lupus in patients treated with anti-TNFα agents (infliximab, etanercept, and adalimumab).

© 2005 Lippincott Williams & Wilkins, Inc.

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